Research provides insights on the link between kidney damage and cognitive impairment

November 17, 2016, American Society of Nephrology

People with kidney disease are at high risk of cognitive impairment, but the nature of this relationship remains uncertain. A new analysis that investigates this link will be presented at ASN Kidney Week 2016 November 15¬-20 at McCormick Place in Chicago, IL.

For the analysis, Daniel Weiner, MD, FASN (Tufts Medical Center) and his colleagues gathered information from the Systolic Blood Pressure INTervention (SPRINT) cognition substudy, SPRINT-MIND. Among 9361 SPRINT-MIND participants, 2800 were administered an expanded cognitive battery at the start of the study and 2707 had complete data; 637 also had brain imaging.

After adjusting for various demographic and clinical characteristics, higher albumin in the urine, which is indicative of poor kidney function, was linked with worse performance on tests of global cognitive function, executive function, memory, and attention. Each doubling of the amount of albumin in the urine was akin to the effect of 6 to 14 months of aging in these cognitive domains. Lower estimated , another indicator of poor kidney function, was linked with worse performance on tests of global cognitive function and memory. In the subset of participants with brain imaging, higher albumin in the urine was associated with abnormal white matter regions in the brain.

"The findings cement the association between kidney damage and cognitive functioning, suggesting that albumin in the urine and changes in brain structure are likely both representations of the same vascular process, just in different organs," said Dr. Weiner. "This manifests with worse brain function, particularly in domains linked to cerebrovascular disease. The fact that this comes from baseline data in the SPRINT trial suggests that these findings are likely relevant to tens of millions of US adults."

Explore further: Metabolite secreted in urine may cause cognitive impairment in kidney failure patients

More information: Study: "Cognitive Function and Kidney Disease: Baseline Data from the SPRINT Trial" (Abstract 744)

Related Stories

Metabolite secreted in urine may cause cognitive impairment in kidney failure patients

July 21, 2016
Retention of certain metabolites in the blood may contribute to cognitive impairment in patients with kidney failure, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology ...

Smoking may block some of the benefits of kidney disease medications

November 17, 2016
To improve care for patients with kidney dysfunction, investigators are striving to identify modifiable risk factors that may slow the progression of chronic kidney disease (CKD) to kidney failure. A new study suggests that ...

High blood pressure and brain health are linked

October 10, 2016
High blood pressure, especially in middle age, is associated with an increased risk of cognitive impairment later in life, according to a new statement from the American Heart Association.

Research connects first-time kidney stone formers and chronic kidney disease

November 2, 2016
Mayo Clinic nephrologists have uncovered a connection between first-time kidney stone formers and chronic kidney disease. In a paper published today in Mayo Clinic Proceedings, researchers announce a persistent decline in ...

Chronic kidney disease as common as type 2 diabetes

October 14, 2016
Around six per cent of Stockholmers are thought to have chronic kidney disease, roughly as many as those suffering from type 2 diabetes. There is, however, a major difference between the two: chronic kidney disease is in ...

Chronic kidney disease a warning sign independent of hypertension or diabetes

September 25, 2012
Two new studies from the Johns Hopkins Bloomberg School of Public Health and the Chronic Kidney Disease Prognosis Consortium found that the presence of chronic kidney disease itself can be a strong indicator of the risk of ...

Recommended for you

Effect of oral alfacalcidol on clinical outcomes in patients without secondary hyperparathyroidism

December 11, 2018
Treatment with active vitamin D did not decrease cardiovascular events in kidney patients undergoing hemodialysis, according to a research group in Japan. They have reported their research results in the December 11 issue ...

Study identifies a key cellular mechanism that triggers pneumonia in humans

December 11, 2018
The relationship between influenza and pneumonia has long been observed by health workers. Its genetic and cellular mechanisms have now been investigated in depth by scientists in a study involving volunteers and conducted ...

Human antibody discovery could save lives from fungal killer

December 11, 2018
A new way to diagnose, treat and protect against stealth fungal infections that claim more than 1.5 million lives per year worldwide has been moved a step closer, according to research published in Nature Communications.

Dialysis patients at risk of progressive brain injury

December 10, 2018
Kidney dialysis can cause short-term 'cerebral stunning' and may be associated with progressive brain injury in those who receive the treatment for many years. For many patients with kidney failure awaiting a kidney transplant ...

Silicosis is on the rise, but is there a therapeutic target?

December 6, 2018
Researchers from the CNRS, the University of Orléans, and the company Artimmune, in collaboration with Turkish clinicians from Atatürk University, have identified a key mechanism of lung inflammation induced by silica exposure, ...

PET scans to optimize tuberculosis meningitis treatments and personalize care, study finds

December 6, 2018
Although relatively rare in the United States, and accounting for fewer than 5 percent of tuberculosis cases worldwide, TB of the brain—or tuberculosis meningitis (TBM)—is often deadly, always hard to treat, and a particular ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.