Methylation of gene panel may help predict breast CA survival

Methylation of gene panel may help predict breast CA survival

(HealthDay)—Methylation of a gene panel is a strong predictor of survival outcomes in metastatic breast cancer (MBC), according to a study published online Nov. 21 in the Journal of Clinical Oncology.

Kala Visvanathan, M.B.B.S., from the Johns Hopkins University School of Medicine in Baltimore, and colleagues used a new quantitative multiplex assay to predict survival outcomes in MBC. Ten genes were tested in duplicate serum samples at baseline, week four, and first restaging for 141 women. On the basis of six of the 10 genes, a cumulative methylation index (CMI) was generated, and correlations with progression-free survival (PFS), overall survival (OS), and disease status at first restaging were assessed.

The researchers found that women with a high CMI had shorter median PFS and OS (2.1 and 12.3 months, respectively), compared with a low CMI (5.8 and 21.7 months, respectively). Among women with MBC, a high versus low CMI at week four independently correlated with worse PFS and OS (hazard ratios, 1.79 and 1.75, respectively) in multivariable models. A CMI increase from baseline to week four correlated with worse PFS and progressive disease at first restaging (both P < 0.001). Even in the presence of circulating tumor cells, week four CMI was a strong predictor of PFS (P = 0.004).

"Methylation of this gene panel is a strong predictor of in MBC and may have clinical usefulness in risk stratification and disease monitoring," the authors write.

Several authors disclosed financial ties to the biopharmaceutical industry. Several authors are named on patents relating to methylation and cancer.


Explore further

Survival up after progression in HPV-positive oropharynx CA

More information: Full Text
Journal information: Journal of Clinical Oncology

Copyright © 2016 HealthDay. All rights reserved.

Citation: Methylation of gene panel may help predict breast CA survival (2016, November 29) retrieved 25 November 2020 from https://medicalxpress.com/news/2016-11-methylation-gene-panel-breast-ca.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
0 shares

Feedback to editors

User comments