Study uncovers link between constipation and kidney disease

Researchers have discovered a link between constipation and poor kidney health. The findings, which appear in an upcoming issue of the Journal of the American Society of Nephrology (JASN), suggest that the diagnosis and management of constipation might be helpful for preventing or treating kidney disease.

Constipation is a common condition, and it can have a variety of impacts on health. For example, is known to increase individuals' risk of cardiovascular disease, potentially through effects caused by gut bacteria.

To investigate any possible association between constipation and , Keiichi Sumida, MD and Csaba Kovesdy, MD (University of Tennessee Health Science Center and Memphis VA Medical Center) studied information on more than 3.5 million US veterans with normal kidney function who were initially examined in 2004 and 2006 and were followed through 2013.

Compared with patients without constipation, patients with constipation had a 13% higher likelihood of developing chronic kidney disease and a 9% higher likelihood of developing , after adjusting for various patient characteristics. More severe constipation was linked with an incrementally higher risk for both and kidney failure.

"Our findings highlight the plausible link between the gut and the kidneys and provide additional insights into the pathogenesis of kidney disease progression," said Dr. Kovesdy. "Our results suggest the need for careful observation of kidney function trajectory in patients with constipation, particularly among those with more severe constipation." He added that if additional research reveals that constipation plays a causal role in kidney disease, treatment of constipation through lifestyle modifications and/or use of probiotics could potentially protect patients' kidney .

Explore further

Research connects first-time kidney stone formers and chronic kidney disease

More information: JASN, DOI: 10.1681/ASN.2016060656
Citation: Study uncovers link between constipation and kidney disease (2016, November 10) retrieved 28 October 2021 from
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Feedback to editors