Lifestyle intervention reduces portal pressure in cirrhosis

January 4, 2017

(HealthDay)—For overweight/obese patients with compensated cirrhosis and portal hypertension, a lifestyle intervention can reduce body weight and portal pressure, according to a study published online Dec. 20 in Hepatology.

Annalisa Berzigotti, M.D., from the Instituto de Salud Carlos III in Madrid, and colleagues conducted a multicentric uncontrolled pilot study involving patients with compensated cirrhosis, portal hypertension (hepatic venous pressure gradient [HVPG] ≥6 mm Hg), and (BMI) of ≥26 kg/m² in an intensive 16-week program. Before and after the intervention, they measured HVPG, body weight and composition, adipokines, health-related quality-of-life, and safety data. Fifty patients completed the study.

The researchers observed a significant decrease in body weight with the lifestyle intervention, by ≥5 percent in 52 percent and ≥10 percent in 16 percent. There was also a significant decrease in HVPG, by ≥10 percent in 42 percent and ≥20 percent in 24 percent. There was a correlation between a ≥10 percent body weight loss and a greater decrease in HVPG (P = 0.024). There were no episodes of clinical decompensation. Weight loss at 16 weeks persisted at six months.

"Sixteen weeks of diet and moderate exercise were safe and reduced and portal pressure in overweight/obese patients with cirrhosis and ," the authors write.

Explore further: New advances in the management of patients with cirrhosis

More information: Full Text (subscription or payment may be required)

Related Stories

New advances in the management of patients with cirrhosis

April 25, 2013
New data from clinical studies presented for the first time at the International Liver Congress 2013 provide new rationale for an old and established treatment option for portal hypertension. Additionally, spleen stiffness ...

Study suggests obesity accelerates progression of cirrhosis

July 21, 2011
Researchers from the United States and Europe involved in an NIH-funded multicenter study have determined that increased body mass index (BMI) is an independent predictor of clinical decompensation in patients with compensated ...

Bariatric surgery may reduce heart failure risk

November 14, 2016
Bariatric surgery and other treatments that cause substantial weight loss can significantly reduce the risk of heart failure in obese patients, according to preliminary research presented at the American Heart Association's ...

Hypocaloric diet, exercise both reduce visceral adiposity

June 3, 2016
(HealthDay)—Both hypocaloric diet and exercise reduce visceral adiposity (VAT), with exercise tending to have a larger effect on reducing VAT, according to a review published online May 23 in Obesity Reviews.

Behavioral weight loss program assists breast cancer survivors

September 9, 2015
(HealthDay)—For overweight/obese survivors of breast cancer, a behavioral weight loss intervention can lead to clinically meaningful weight loss, according to a study published online Aug. 17 in the Journal of Clinical ...

Recommended for you

Scientists discover a new way to treat type 2 diabetes

July 21, 2017
Medication currently being used to treat obesity is also proving to have significant health benefits for patients with type 2 diabetes. A new study published today in Molecular Metabolism explains how this therapeutic benefit ...

Alzheimer's drug cuts hallmark inflammation related to metabolic syndrome by 25 percent

July 20, 2017
An existing Alzheimer's medication slashes inflammation and insulin resistance in patients with metabolic syndrome, a potential therapeutic intervention for a highly dangerous condition affecting 30 percent of adults in the ...

Diabetes or its precursor affects 100 million Americans

July 19, 2017
Almost one-third of the US population—100 million people—either has diabetes or its precursor condition, known as pre-diabetes, said a government report Tuesday.

One virus may protect against type 1 diabetes, others may increase risk

July 11, 2017
Doctors can't predict who will develop type 1 diabetes, a chronic autoimmune disease in which the immune system destroys the cells needed to control blood-sugar levels, requiring daily insulin injections and continual monitoring.

Diabetes complications are a risk factor for repeat hospitalizations, study shows

July 7, 2017
For patients with diabetes, one reason for hospitalization and unplanned hospital readmission is severe dysglycemia (uncontrolled hyperglycemia - high blood sugar, or hypoglycemia - low blood sugar), says new research published ...

Researchers identify promising target to protect bone in patients with diabetes

July 7, 2017
Utilizing metabolomics research techniques, NYU Dentistry researchers investigated the underlying biochemical activity and signaling within the bone marrow of hyperglycemic mice with hopes of reducing fracture risks of diabetics

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.