Lifestyle intervention reduces portal pressure in cirrhosis
(HealthDay)—For overweight/obese patients with compensated cirrhosis and portal hypertension, a lifestyle intervention can reduce body weight and portal pressure, according to a study published online Dec. 20 in Hepatology.
Annalisa Berzigotti, M.D., from the Instituto de Salud Carlos III in Madrid, and colleagues conducted a multicentric uncontrolled pilot study involving patients with compensated cirrhosis, portal hypertension (hepatic venous pressure gradient [HVPG] ≥6 mm Hg), and body mass index (BMI) of ≥26 kg/m² in an intensive 16-week lifestyle intervention program. Before and after the intervention, they measured HVPG, body weight and composition, adipokines, health-related quality-of-life, and safety data. Fifty patients completed the study.
The researchers observed a significant decrease in body weight with the lifestyle intervention, by ≥5 percent in 52 percent and ≥10 percent in 16 percent. There was also a significant decrease in HVPG, by ≥10 percent in 42 percent and ≥20 percent in 24 percent. There was a correlation between a ≥10 percent body weight loss and a greater decrease in HVPG (P = 0.024). There were no episodes of clinical decompensation. Weight loss at 16 weeks persisted at six months.
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