Parathyroid hormone linked to arterial stiffness in T1DM

January 11, 2017

(HealthDay)—In individuals with type 1 diabetes, parathyroid hormone (PTH) is associated with arterial stiffness, even after adjustment for multiple confounding variables, according to research published online Jan. 6 in Diabetes Care.

Emilie H. Zobel, M.D., from the Steno Diabetes Center in Gentofte, Denmark, and colleagues examined the correlation between , evaluated by carotid-femoral pulse wave velocity (cfPWV), and bone mass density in a well-characterized cohort of 347 individuals with type 1 diabetes.

The researchers found that , all clinical bone markers, and markers of mineral metabolism, except calcium, phosphorus, and Dickkopf 1, correlated with cfPWV in unadjusted analyses (P ≤ 0.041). The level of bone mineral density, the clinical bone marker PTH, and the marker of bone mineral metabolism sclerostin correlated with cfPWV after adjustment for age, sex, and mean arterial pressure (P ≤ 0.027). PTH remained positively associated with cfPWV after further adjustment for additional risk factors, including hemoglobin A1c, total cholesterol, body mass index, antihypertensive treatment, rate, estimated , and smoking (P = 0.014).

"Our findings highlight PTH as a potential mediator for the cross talk between bone and vascular disease," the authors write. "However, our findings need validation, and prospective studies investigating the relationship between PTH and cardiovascular outcome in type 1 diabetes are warranted."

Explore further: Summer concentrations of 25OHD predict bone mineral density

More information: Full Text (subscription or payment may be required)

Related Stories

Summer concentrations of 25OHD predict bone mineral density

October 4, 2016
(HealthDay)—Summer levels of serum 25-hydroxyvitamin D (S-25OHD) are associated with bone mineral density of the total hip, according to a study published online Sept. 25 in the Journal of Internal Medicine.

Some apolipoproteins linked to incident type 2 diabetes

January 5, 2017
(HealthDay)—Apolipoprotein (apo) CIII and apoCIII-to-apoA1 ratio are correlated with incident type 2 diabetes (T2D), according to a study published online Dec. 28 in Diabetes Care.

Uric acid levels low in teens with type 1 diabetes

March 1, 2016
(HealthDay)—Plasma uric acid (PUA) levels are significantly lower in adolescent patients with type 1 diabetes (T1D) than in healthy control subjects, and there does not appear to be a link between PUA levels and cardiorenal ...

Menopausal hormone therapy improves bone health

November 17, 2016
Women who undergo hormone therapy for menopausal symptoms such as hot flashes can not only increase bone mass, but also can improve bone structure, according to a new study published in the Endocrine Society's Journal of ...

Romosozumab increases bone mineral density post-menopause

January 6, 2014
(HealthDay)—Romosozumab seems safe and effective for increasing bone mineral density in postmenopausal women with low bone mineral density, according to a study published online Jan. 1 in the New England Journal of Medicine.

Arterial stiffness inversely tied to plasma adiponectin levels

September 27, 2012
(HealthDay)—Arterial stiffness is inversely related to plasma adiponectin levels in young, normotensive patients with type 1 diabetes, according to a study published online Sept. 21 in Diabetes Care.

Recommended for you

Genetic discovery may help better identify children at risk for type 1 diabetes

January 17, 2018
Six novel chromosomal regions identified by scientists leading a large, prospective study of children at risk for type 1 diabetes will enable the discovery of more genes that cause the disease and more targets for treating ...

Women who have gestational diabetes in pregnancy are at higher risk of future health issues

January 16, 2018
Women who have gestational diabetes mellitus (GDM) during pregnancy have a higher than usual risk of developing type 2 diabetes, hypertension, and ischemic heart disease in the future, according to new research led by the ...

Diabetes gene found that causes low and high blood sugar levels in the same family

January 15, 2018
A study of families with rare blood sugar conditions has revealed a new gene thought to be critical in the regulation of insulin, the key hormone in diabetes.

Discovery could lead to new therapies for diabetics

January 12, 2018
New research by MDI Biological Laboratory scientist Sandra Rieger, Ph.D., and her team has demonstrated that an enzyme she had previously identified as playing a role in peripheral neuropathy induced by cancer chemotherapy ...

Enzyme shown to regulate inflammation and metabolism in fat tissue

January 11, 2018
The human body has two primary kinds of fat—white fat, which stores excess calories and is associated with obesity, and brown fat, which burns calories in order to produce heat and has garnered interest as a potential means ...

Big strides made in diabetes care

January 5, 2018
(HealthDay)—This past year was a busy, productive one for diabetes research and care.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.