Antidepressant efficacy varies for depressive symptom clusters

Antidepressant efficacy varies for depressive symptom clusters

(HealthDay)—Antidepressant treatment efficacy varies for empirically-defined clusters of symptoms, according to a study published online Feb. 22 in JAMA Psychiatry.

Adam M. Chekroud, from Yale University in New Haven, Conn., and colleagues determined the efficacy of antidepressant treatments on empirically defined groups of . Data on patients with from the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial were used to identify clusters of symptoms. These findings were replicated using the Combining Medications to Enhance Depression Outcomes (CO-MED) trial. Using intent-to-treat data for the 4,706 patients from both trials, the authors examined whether observed symptom clusters have differential response trajectories; data were also included for 2,515 additional placebo and active-comparator phase 3 trials of duloxetine.

The researchers found that at baseline, there were three symptom clusters identified in the self-reported Quick Inventory of Depressive Symptomatology scale in STAR*D, which was replicated in CO-MED and was similar for the clinician-rated Hamilton Depression rating scale. Eight of nine antidepressants were more effective for core emotional symptoms than for sleep or atypical symptoms. Between-drug differences in efficacy were often greater than the difference between treatments and placebo.

"Selecting the best drug for a given may have a bigger benefit than that gained by use of an active compound versus a placebo," the authors write.

Several authors disclosed financial ties to the pharmaceutical industry.


Explore further

Data on depression suggest possibility of personalized treatments

More information: Abstract/Full Text (subscription or payment may be required)
Journal information: JAMA Psychiatry

Copyright © 2017 HealthDay. All rights reserved.

Citation: Antidepressant efficacy varies for depressive symptom clusters (2017, February 28) retrieved 24 January 2021 from https://medicalxpress.com/news/2017-02-antidepressant-efficacy-varies-depressive-symptom.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
1 shares

Feedback to editors

User comments