Aspirin may increase pregnancy chances in women with high inflammation, study finds

February 8, 2017, National Institutes of Health
Pregnancy
Pregnancy test. Credit: public domain

A daily low dose of aspirin may help a subgroup of women, those who have previously lost a pregnancy, to successfully conceive and carry a pregnancy to term, according to an analysis by researchers at the National Institutes of Health. The women who benefited from the aspirin treatment had high levels of C-reactive protein (CRP), a substance in the blood indicating system-wide inflammation, which aspirin is thought to counteract. The study appears in the Journal of Clinical Endocrinology and Metabolism.

Researchers at NIH's Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) analyzed data originally obtained from the Effects of Aspirin in Gestation and Reproduction (EAGeR) trial. The trial sought to determine if daily low-dose could prevent subsequent loss among who had one or two prior losses.

For the current study, researchers classified the women into 3 groups: low CRP (below .70 mg per liter of blood), mid CRP (from .70 to 1.95) and high CRP (at or above 1.95). Women within each group received either daily low-dose aspirin or a placebo. In their analysis, researchers found no significant differences in birth rates between those receiving aspirin and those receiving placebo in both the low CRP and mid CRP groups. For the high CRP group, those taking the placebo had the lowest rate of live birth at 44 percent, while those taking daily aspirin had a live-birth rate of 59 percent—a 35-percent increase. Aspirin also appeared to reduce CRP levels in the high CRP group when measured during weeks 8, 20, and 36 of pregnancy.

The authors concluded that more research is needed to confirm the findings and to examine the potential influence of inflammation in becoming pregnant and maintaining pregnancy.

Explore further: Aspirin does not prevent pregnancy loss, study finds

More information: Sjaarda LA, et al. Preconception low-dose aspirin restores diminished pregnancy and live birth rates in women with low grade inflammation: a secondary analysis of a randomized trial (link is external). Journal of Clinical Endocrinology and Metabolism.  DOI: doi.org/10.1210/jc.2016-2917

Related Stories

Aspirin does not prevent pregnancy loss, study finds

April 3, 2014
(Medical Xpress)—A daily low dose of aspirin does not appear to prevent subsequent pregnancy loss among women with a history of one or two prior pregnancy losses, according to researchers at the National Institutes of Health.

Conception soon after a pregnancy loss may increase chances of live birth

January 13, 2016
Couples who attempt to conceive within three months after losing an early pregnancy, defined as less than 20 weeks gestation, have the same chances, if not greater, of achieving a live birth than those who wait for three ...

Letrozole tops aspirin for halting ovarian hyperstimulation

January 5, 2017
(HealthDay)—For high-risk women, letrozole is more effective than aspirin for decreasing the incidence of moderate and severe early-onset ovarian hyperstimulation syndrome, according to a study published in the January ...

Give aspirin to all pregnant women at risk of preeclampsia, US experts say

September 9, 2014
(HealthDay)—Women at high risk for the pregnancy complication known as preeclampsia should take low-dose aspirin daily after 12 weeks of pregnancy, a panel of U.S. health experts recommends.

No strong evidence to support aspirin use for IVF

August 10, 2011
A systematic review published in The Cochrane Library did not find compelling evidence to support the routine use of aspirin in women being treated for IVF. The researchers reported that taking aspirin during an IVF cycle ...

Recommended for you

Study finds women with pregnancy-related nausea, vomiting use marijuana more

August 20, 2018
A Kaiser Permanente study, published today in JAMA Internal Medicine, found that women with mild and severe nausea and vomiting in pregnancy were significantly more likely to have used marijuana during pregnancy than women ...

Blood test may identify gestational diabetes risk in first trimester

August 16, 2018
A blood test conducted as early as the 10th week of pregnancy may help identify women at risk for gestational diabetes, a pregnancy-related condition that poses potentially serious health risks for mothers and infants, according ...

Artificial placenta created in the laboratory

August 14, 2018
In order to better understand important biological membranes, it is necessary to explore new methods. Researchers at Vienna University of Technology (Vienna) have succeeded in creating an artificial placental barrier on a ...

The inequalities of prenatal stress

August 14, 2018
Exposure to an acute stress in utero can have long-term consequences extending into childhood – but only among children in poor households, according to a new Stanford study that looked at the long-term impact of acute, ...

Better studies needed on effectiveness of fertility awareness-based methods for contraception

August 10, 2018
A new systematic review provides the most comprehensive assessment to date on the scientific evidence estimating the effectiveness of various fertility awareness-based methods (FABMs) for contraception. "Effectiveness of ...

Inducing labor at 39 weeks reduces likelihood of C-sections

August 8, 2018
Inducing labor in healthy first-time mothers in the 39th week of pregnancy results in lower rates of cesarean sections compared with waiting for labor to begin naturally at full term, according to a multicenter study funded ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.