Reduced endothelium-dependent vasodilation in T2DM

Reduced endothelium-dependent vasodilation in T2DM
(HealthDay)—Patients with type 2 diabetes have reduced endothelium-dependent vasodilation, regardless of the presence of polyneuropathy, according to a study published online Feb. 15 in Diabetes Care.

Anna L. Emanuel, from the VU University Medical Center in Amsterdam, and colleagues compared skin microvascular function in 16 healthy controls (HCs), 16 patients with cryptogenic axonal polyneuropathy (CAP), 15 patients with type 2 diabetes with polyneuropathy (DPN), and 11 patients with type 2 diabetes without polyneuropathy. Skin biopsy and were used to assess .

The researchers found that, compared with HCs, patients with CAP and DPN demonstrated a similar decrease in intraepidermal nerve fiber density and sural sensory nerve action potential. Compared with HCs, patients with CAP had a similar vasodilator response to acetylcholine (relative mean difference based on log values, 13.3 percent; P = 0.652), but with diabetes, with and without neuropathy, had lower response (157.5 and 174.2 percent; both P = 0.003). There were no significant differences between the patient groups with diabetes (P = 0.845). The vasodilator response to sodium nitroprusside did not differ significantly among the groups (P = 0.0802).

"These data suggest that in type 2 diabetes, neuropathy does not contribute to impaired microvascular endothelium-dependent vasodilation and vice versa," the authors write.

One author is an employee of Biogen, which funded the study.


Explore further

Median neuropathy at the wrist may signal diabetic neuropathy

More information: Abstract/Full Text (subscription or payment may be required)
Journal information: Diabetes Care

Copyright © 2017 HealthDay. All rights reserved.

Citation: Reduced endothelium-dependent vasodilation in T2DM (2017, February 21) retrieved 21 May 2019 from https://medicalxpress.com/news/2017-02-endothelium-dependent-vasodilation-t2dm.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
0 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more