Vitamin E, selenium supplements did not prevent dementia

March 20, 2017, The JAMA Network Journals
Credit: CC0 Public Domain

Antioxidant supplements vitamin E and selenium - taken alone or in combination - did not prevent dementia in asymptomatic older men, according to a study published online by JAMA Neurology.

Antioxidants as potential treatment for cognitive impairment or dementia have been of interest for years because has been implicated as a dementia pathway.

The Prevention of Alzheimer's Disease by Vitamin E and Selenium (PREADViSE) clinical trial initially enrolled 7,540 older men who used the supplements for an average of about five years and a subset of 3,786 men who agreed to be observed longer. The men received either vitamin E, , both or a placebo.

The incidence of dementia (325 of 7,338 men [4.4 percent]) was not different among the four study groups, according to the results in the article by Richard J. Kryscio, Ph.D., of the University of Kentucky, Lexington, and coauthors.

Limitations of the study include losing about half of the participants to long-term follow-up during the transition from a to a cohort study. Publicity about the negative effect of supplements also may have played a role, according to the authors.

"The supplemental use of vitamin E and selenium did not forestall dementia and are not recommended as preventive agents. This conclusion is tempered by the underpowered study, inclusion of only men, a short supplement exposure time, dosage considerations and methodologic limitations in relying on real-world reporting of incident cases," the article concludes.

Explore further: Vitamin E, selenium supplements unlikely to effect age-related cataracts in men

More information: JAMA Neurol. Published online March 20, 2017. DOI: 10.1001/jamaneurol.2016.5778

Related Stories

Vitamin E, selenium supplements unlikely to effect age-related cataracts in men

September 18, 2014
Taking daily supplements of selenium and/or vitamin E appears to have no significant effect on the development of age-related cataracts in men, writes Author William G. Christen, Sc.D., of Brigham & Women's Hospital and Harvard ...

Vitamin E and selenium don't prevent polyps that can lead to colorectal cancer

December 19, 2016
Eight years ago, results from a landmark cancer prevention trial run by SWOG showed that a daily dose of vitamin E and selenium did not prevent prostate cancer. In fact, the Selenium and Vitamin E Cancer Prevention Trial ...

Cataract risk not down with long-tem selenium, vitamin E

January 9, 2015
(HealthDay)—Long-term supplementation with selenium or vitamin E is not associated with a reduction in the risk of age-related cataract among men, according to a study published in the January issue of JAMA Ophthalmology.

Selenium and vitamin E supplementation over recommended dietary intake may raise prostate cancer risk

February 21, 2014
A multi-center study led by Fred Hutchinson Cancer Research Center has found that high-dose supplementation with both the trace element selenium and vitamin E increase the risk of high-grade prostate cancer. But importantly, ...

Incidence of dementia in primary care increased in the Netherlands over 23 years

March 7, 2017
The incidence of registered dementia cases has increased slightly over a 23-year period (1992 to 2014) in the Netherlands, according to a study published by Emma van Bussel and colleagues from the Academic Medical Center ...

Team questions safety, efficacy of selenium and colorectal cancer risk

October 14, 2016
A 12-year study led by a team of University of Arizona Cancer Center researchers is bringing into question the safety and efficacy of selenium, a popular nutritional supplement touted to combat and reduce the risk of colorectal ...

Recommended for you

Moderate to high intensity exercise does not slow cognitive decline in people with dementia

May 16, 2018
Moderate to high intensity exercise does not slow cognitive (mental) impairment in older people with dementia, finds a trial published by The BMJ today.

Mutation discovered to protect against Alzheimer's disease in mice

May 16, 2018
Researchers at the RIKEN Center for Brain Science have discovered a mutation that can protect against Alzheimer's disease in mice. Published in the scientific journal Nature Communications, the study found that a specific ...

Most deprived are nearly twice as likely to develop dementia

May 16, 2018
Older adults in England with fewer financial resources are more likely to develop dementia, according to new UCL research.

Scientists discover a variation of the genome predisposing to Alzheimer's disease

May 15, 2018
An article published in Nature Medicine shows that the inheritance of small changes in DNA alters the expression of the PM20D1 gene and is associated with an increased risk of developing Alzheimer's disease.

Restoring epigenetic balance reinstates memory in flies with Alzheimer's disease symptoms

May 14, 2018
Researchers from Drexel University reversed symptoms of Alzheimer's disease in fruit flies by restoring the balance between two epigenetic enzymes that regulate gene expression, a study shows.

Neuroprotective molecule could improve memory and cognition, reduce Alzheimer's degradation

May 10, 2018
A Purdue University graduate and a Purdue Research Park of Northwest Indiana (NWI) startup have published a research study in Bioorganic & Medicinal Chemistry Letters that identifies a small molecule SERCA activator that ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.