Vitamin E, selenium supplements did not prevent dementia

March 20, 2017, The JAMA Network Journals
Credit: CC0 Public Domain

Antioxidant supplements vitamin E and selenium - taken alone or in combination - did not prevent dementia in asymptomatic older men, according to a study published online by JAMA Neurology.

Antioxidants as potential treatment for cognitive impairment or dementia have been of interest for years because has been implicated as a dementia pathway.

The Prevention of Alzheimer's Disease by Vitamin E and Selenium (PREADViSE) clinical trial initially enrolled 7,540 older men who used the supplements for an average of about five years and a subset of 3,786 men who agreed to be observed longer. The men received either vitamin E, , both or a placebo.

The incidence of dementia (325 of 7,338 men [4.4 percent]) was not different among the four study groups, according to the results in the article by Richard J. Kryscio, Ph.D., of the University of Kentucky, Lexington, and coauthors.

Limitations of the study include losing about half of the participants to long-term follow-up during the transition from a to a cohort study. Publicity about the negative effect of supplements also may have played a role, according to the authors.

"The supplemental use of vitamin E and selenium did not forestall dementia and are not recommended as preventive agents. This conclusion is tempered by the underpowered study, inclusion of only men, a short supplement exposure time, dosage considerations and methodologic limitations in relying on real-world reporting of incident cases," the article concludes.

Explore further: Vitamin E, selenium supplements unlikely to effect age-related cataracts in men

More information: JAMA Neurol. Published online March 20, 2017. DOI: 10.1001/jamaneurol.2016.5778

Related Stories

Vitamin E, selenium supplements unlikely to effect age-related cataracts in men

September 18, 2014
Taking daily supplements of selenium and/or vitamin E appears to have no significant effect on the development of age-related cataracts in men, writes Author William G. Christen, Sc.D., of Brigham & Women's Hospital and Harvard ...

Vitamin E and selenium don't prevent polyps that can lead to colorectal cancer

December 19, 2016
Eight years ago, results from a landmark cancer prevention trial run by SWOG showed that a daily dose of vitamin E and selenium did not prevent prostate cancer. In fact, the Selenium and Vitamin E Cancer Prevention Trial ...

Cataract risk not down with long-tem selenium, vitamin E

January 9, 2015
(HealthDay)—Long-term supplementation with selenium or vitamin E is not associated with a reduction in the risk of age-related cataract among men, according to a study published in the January issue of JAMA Ophthalmology.

Selenium and vitamin E supplementation over recommended dietary intake may raise prostate cancer risk

February 21, 2014
A multi-center study led by Fred Hutchinson Cancer Research Center has found that high-dose supplementation with both the trace element selenium and vitamin E increase the risk of high-grade prostate cancer. But importantly, ...

Incidence of dementia in primary care increased in the Netherlands over 23 years

March 7, 2017
The incidence of registered dementia cases has increased slightly over a 23-year period (1992 to 2014) in the Netherlands, according to a study published by Emma van Bussel and colleagues from the Academic Medical Center ...

Team questions safety, efficacy of selenium and colorectal cancer risk

October 14, 2016
A 12-year study led by a team of University of Arizona Cancer Center researchers is bringing into question the safety and efficacy of selenium, a popular nutritional supplement touted to combat and reduce the risk of colorectal ...

Recommended for you

Hypothesis underpinning dementia research 'flawed'

October 16, 2018
A hypothesis which has been the standard way of explaining how the body develops Alzheimer's Disease for almost 30 years is flawed, according to a University of Manchester biologist.

Many cases of dementia may arise from non-inherited DNA 'spelling mistakes'

October 15, 2018
Only a small proportion of cases of dementia are thought to be inherited—the cause of the vast majority is unknown. Now, in a study published today in the journal Nature Communications, a team of scientists led by researchers ...

Scientists create new map of brain region linked to Alzheimer's disease

October 8, 2018
Curing some of the most vexing diseases first requires navigating the world's most complex structure—the human brain. So, USC scientists have created the most detailed atlas yet of the brain's memory bank.

Previously unknown genetic aberrations found to be associated with Alzheimer's progression

October 8, 2018
In a large-scale analysis of RNA from postmortem human brain tissue, researchers at the Icahn School of Medicine at Mount Sinai and Columbia University have identified specific RNA splicing events associated with Alzheimer's ...

Periodontal disease bacteria may kick-start Alzheimer's

October 4, 2018
Long-term exposure to periodontal disease bacteria causes inflammation and degeneration of brain neurons in mice that is similar to the effects of Alzheimer's disease in humans, according to a new study from researchers at ...

AI could predict cognitive decline leading to Alzheimer's disease in the next five years

October 4, 2018
A team of scientists has successfully trained a new artificial intelligence (AI) algorithm to make accurate predictions regarding cognitive decline leading to Alzheimer's disease.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.