Stopping drug abuse can reverse related heart damage

Quitting methamphetamine use can reverse the damage the drug causes to the heart and improve heart function in abusers when combined with appropriate medical treatment, potentially preventing future drug-related cases of heart failure or other worse outcomes, according to a study published today in JACC: Heart Failure.

"The work presented today emphasizes the fact that the growing drug epidemic will have long term cardiovascular consequences in addition to the known short term tragic events ," said Editor-in-Chief of JACC: Heart Failure Christopher O'Connor, MD, FACC.

Methamphetamines are one of the most frequently used drugs worldwide, and previous studies have shown that -related issues are commonly a factor in death from use. While medical treatments are available for these heart conditions, there is little information about if heart damage can be improved or reversed by discontinuing the drug abuse.

Researchers looked at 30 patients abusing methamphetamines to assess if improved after discontinuing methamphetamine use. Patients were on average 30 years old and over 93 percent were male. All had a left ventricular ejection fraction of less than 40 percent, which is considered evidence of . Over 83 percent were highly symptomatic and suffered from labored breathing. One-third also developed intracardiac thrombi, or blood clots.

All patients received medical treatment including supportive measures and guideline-supported medical therapy, which included automatic implantable cardioverter-defibrillator or wearable cardioverter-defibrillator in some patients. Symptoms and improved significantly in patients who discontinued methamphetamine use. Also, patients who discontinued the drugs had a lower incidence of the primary endpoint of death, non-fatal stroke and rehospitalization for heart failure versus those who continued the abuse methamphetamines while on medical therapy, 57 percent vs. 13 percent, respectively.

"Methamphetamine associated cardiac myopathy will become a growing cause of heart failure in young adults," said Norman Mangner, MD, senior author on the study and a physician at the Heart Center Leipzig in Leipzig, Germany. "Due to the chance to recover cardiac function and symptoms at an early stage of the disease, early detection of heart problems in patients with could prevent further deterioration of the cardiomyopathy."

The study did have limitations, including the possibility for non-compliance to . Also, only patients with heart failure and severely impaired cardiac function were included, so there is no information on the evolution of heart problems caused by methamphetamine use and possible early, asymptomatic phases.

In an accompanying editorial, James L. Januzzi, MD, Hutter Family Professor of Medicine at Harvard Medical School in Boston, said the study provides objective data showing that in methamphetamine abusers, cardiac function will only improve after they quit using the drugs, and these findings should impact the treatment plan.

"Rather than simply placing patients with suspected methamphetamine associated cardiomyopathy on a cocktail of neurohormonal blockade, the majority of focus should be on helping such quit," he said.


Explore further

Scientists identify protein linked to chronic heart failure

More information: JACC: Heart Failure, DOI: 10.1016/j.jchf.2017.02.017
Citation: Stopping drug abuse can reverse related heart damage (2017, May 29) retrieved 25 June 2019 from https://medicalxpress.com/news/2017-05-drug-abuse-reverse-heart.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
0 shares

Feedback to editors

User comments

May 30, 2017
Methamphetamine addiction can be remedied without withdrawal symptoms by taking by mouth 250mg of healthy adult male facial skin surface lipid pheromone
@bubba
links/references?
Our lack of care with our own pheromones has been responsible for much strife among human pheromone researchers.
no... lack of evidence is the problem
http://rspb.royal...full.pdf

May 30, 2017
Just follow the recipe. When they smile real big and start crying, that's when they're cured
@bubba
and if they instead commit suicide or homicide?

this makes you directly liable for their actions should someone treat another with your method and they're not helped and decide to shoot up a school or something
Lack of evidence is not the problem. Lack of intelligence is the problem
so you're saying that if people were more intelligent you would be able to cure them?

no
the problem is that you are making a claim and practicing medicine without a license and you're not willing to be responsible for failure when your obvious crackpot medicinal cure doesn't work

reported for blatantly false claims, refusal to provide evidence as well as illegal practices


May 30, 2017
decided to put this part separate
and the aversive pheromone that throws researchers off track with such career crushing violence from Pharisees such as yourself
so what about the POS criminal frauds like you who target mentally afflicted people?

what kind of scum would that make you?

.

a person with debilitating PTSD or depression (or some of the other so-called disease you claim to be able to cure), they only want to be relieved from their affliction and in a lot of cases they're willing to try anything, no matter how f*cking stupid, just to be normal again and feel good

so a person like you who targets them for the sake of making your money while refusing to show any kind of factual or evidence based trials to which they can rely upon for honest decisions ...

you're the worst type of criminal fraud there is

May 31, 2017
@bubba the pseudoscience snake oil quack
It's a Pied Piper form of jealousy & suspicion
are you stupid?
I thought you claimed to be Mensa level intelligent

when you post "[insert drug addiction or mental illness] can be remedied without withdrawal symptoms by taking [insert your pheromone delusion]" then you are being fraudulent and violating 18 U.S. Code § 249

it is also fraudulent as you can't produce any verifiable science to validate even your cursory claims, like passing the med board

that isn't my misinterpretation, either, you idiot

that is defined clearly in state and federal law as being fraud and a few other things as i linked to you already
you are not a chemist?
neither are you
and i have a whole lot more experience and training in medicine than you ever will
LOL

you're a lying POS fraud, and that is the only thing you've proven


May 31, 2017
@fraudulent bubba the pseudoscience idiot
The pheromone permits only a slight lift in mood most of the time, a bigger lift for
so now it's suddenly not a cure, but a psychotropic?
LMFAO
Jealousy in osculation partners of pheromone treated people
using tech-jargon doesn't impress people, especially when you have yet to provide any reputable secondary sources to validate your claims

it is also demonstrable fraud in that you're attempting to obfuscate
eschew obfuscation, and link references or STFU
Criminal behavior always ceases for the taker of the pheromone
this is fraud and i can prove it: you haven't ceased in your Criminal behavior

you're a lying POS fraud, and that is the only thing you've proven

May 31, 2017
@fraudulent bubba the pseudoscience idiot
I am unfamiliar with the psychotropic
you claim to have attended med school and passed the boards but you don't know that a psychoactive drug, psychopharmaceutical, or psychotropic is a chemical substance that changes brain function and results in alterations in perception, mood, consciousness or behavior?

you're a fraud
. Osculation means mouth to mouth kissing
unlike you, i know what it means
i also know you're attempts to utilise med jargon have outed you as a fraudulent quack
I am the primary source for this information
if there is no way to validate the claims then this isn't science, it's pseudoscience

therefore you're fraudulently pushing a psychotropic regulated by the gov't

you should have checked with some lawyers first

the only thing you've been able to prove with any success is that you're a fraud

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more