Faster image processing for neuroscience

May 3, 2017, Oak Ridge National Laboratory
A still image processed using ORNL software tracks a migrating neuron within a mouse's brain. Credit: Oak Ridge National Laboratory

Oak Ridge National Laboratory scientists designed software for St. Jude Children's Research Hospital that significantly sped processing of microscopy images used in brain development research.

The software provided frame-by-frame analysis of video taken of a mouse brain cell in a matter of hours compared with traditional manual techniques that can take weeks. St. Jude's researchers are exploring how neurons migrate in the developing to better understand how defects in the process may result in certain disorders such as epilepsy or .

"Automatic processing of the images saves time and provides more data for better statistics in these studies," said ORNL's Ryan Kerekes. Dr. David Solecki of St. Jude's Developmental Neurobiology Department said his collaboration with ORNL has been "indispensable."

The ORNL tools "free up biologists to do what they do best: apply their expert knowledge to analysis tasks," he said. Results of the research were published in Nature Communications.

Credit: Oak Ridge National Laboratory

Explore further: ORNL image analysis prowess advances retina research

More information: Niraj Trivedi et al. Drebrin-mediated microtubule–actomyosin coupling steers cerebellar granule neuron nucleokinesis and migration pathway selection, Nature Communications (2017). DOI: 10.1038/ncomms14484

Related Stories

ORNL image analysis prowess advances retina research

December 21, 2011
Armed with a new ability to find retinal anomalies at the cellular level, neurobiologists at St. Jude Children's Research Hospital have made a discovery they hope will ultimately lead to a treatment for cancer of the retina.

Recommended for you

New neurons in the adult brain are involved in sensory learning

February 23, 2018
Although we have known for several years that the adult brain can produce new neurons, many questions about the properties conferred by these adult-born neurons were left unanswered. What advantages could they offer that ...

Do you see what I see? Researchers harness brain waves to reconstruct images of what we perceive

February 22, 2018
A new technique developed by neuroscientists at the University of Toronto Scarborough can, for the first time, reconstruct images of what people perceive based on their brain activity gathered by EEG.

Neuroscientists discover a brain signal that indicates whether speech has been understood

February 22, 2018
Neuroscientists from Trinity College Dublin and the University of Rochester have identified a specific brain signal associated with the conversion of speech into understanding. The signal is present when the listener has ...

Study in mice suggests personalized stem cell treatment may offer relief for multiple sclerosis

February 22, 2018
Scientists have shown in mice that skin cells re-programmed into brain stem cells, transplanted into the central nervous system, help reduce inflammation and may be able to help repair damage caused by multiple sclerosis ...

Biomarker, clues to possible therapy found in novel childhood neurogenetic disease

February 22, 2018
Researchers studying a rare genetic disorder that causes severe, progressive neurological problems in childhood have discovered insights into biological mechanisms that drive the disease, along with early clues that an amino ...

A look at the space between mouse brain cells

February 22, 2018
Between the brain's neurons and glial cells is a critical but understudied structure that's been called neuroscience's final frontier: the extracellular space. With a new imaging paradigm, scientists can now see into and ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.