Fluid overload linked to premature death in patients on dialysis

New research indicates that sustained fluid overload—when there is too much fluid in the blood—may increase the risk of early death in kidney failure patients on hemodialysis. The findings, which appear in an upcoming issue of the Journal of the American Society of Nephrology (JASN), point to the importance of monitoring and treating fluid overload in these patients.

Sustained fluid overload can have a variety of consequences, including swelling, discomfort, hypertension, and heart problems. Although it is a major cause of concern for patients with who are on hemodialysis, only a few small studies have looked at the relationship between fluid overload and premature death in these patients.

To investigate, Carmine Zoccali, MD (CNR-IFC, Clinical Epidemiology and Physiopathology of Renal Diseases and Hypertension of Reggio Calabria, Italy) and his colleagues examined an extensive clinical database of a large international dialysis network. The team's analyses were based on more than 200,000 measurements of fluid status in 39,566 patients initiating hemodialysis in 26 countries in Europe, Africa, the Middle East, and Latin America.

The researchers studied the relationship between fluid overload measured just once at the start of regular dialysis treatment and mortality, as well as the relationship between cumulative exposure to fluid overload over 1 year and mortality. They found that cumulative fluid overload over 1 year predicted a higher risk of death than the single measurement made at the start of regular dialysis treatment. "Ours is the first study providing information about the risk of persistent fluid overload in ," said Dr. Zoccali. "Remarkably, the excess risk for death attributable to persistent overload was similar to the risk observed with , heart failure, and being 12 years older."


Explore further

Ultrasound to detect lung congestion in dialysis patients may help save lives

More information: "Chronic Fluid Overload and Mortality in End Stage Kidney Disease," Journal of the American Society of Nephrology (2017). DOI: 10.1681/ASN.2016121341
Citation: Fluid overload linked to premature death in patients on dialysis (2017, May 4) retrieved 25 August 2019 from https://medicalxpress.com/news/2017-05-fluid-overload-linked-premature-death.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
1 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more