Certain criteria may be better than others in RA assessment

June 19, 2017

(HealthDay)—For patients with rheumatoid arthritis (RA), the performances of the Clinical Disease Activity Index (CDAI) and Simplified Disease Activity Index (SDAI) appear to be better than that of the Disease Assessment Score of 28 joints—C-reactive protein (DAS-28-CRP), according to a study published online June 12 in the International Journal of Rheumatic Diseases.

Pooja Dhaon, M.D., from Hind Institute of Medical Sciences in Safedabad, India, and colleagues included 135 patients with RA in a prospective study. The authors assessed at baseline and every six weeks for 24 weeks by DAS-28-CRP, CDAI, and SDAI. Based on pre-defined cut-offs, patients were classified into groups of remission, low , moderate activity, and high activity.

The researchers found that at baseline there was an excellent positive correlation between DAS-28-CRP and both CDAI (linear weighted κ, 0.545) and SDAI (linear weighted κ, 0.689). At the final visit there was moderate agreement between DAS-28-CRP and CDAI (linear weighted κ, 0.458) and between SDAI and DAS-28-CRP (linear weighted κ, 0.470). At baseline and the final visit, the correlation between CDAI and SDAI remained excellent. Significantly more residual disease activity was seen for patients in remission as per DAS-28-CRP versus SDAI and CDAI remission criteria.

"SDAI- and CDAI-based remission criteria seem to be better than DAS-28-CRP-based remission criteria," the authors write.

Explore further: ACR endorses standardized measures to determine rheumatoid arthritis disease activity

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

ACR endorses standardized measures to determine rheumatoid arthritis disease activity

April 2, 2012
A working group convened by the American College of Rheumatology (ACR) has evaluated more than 60 disease activity measures for rheumatoid arthritis (RA). The group narrowed the number of RA disease activity measures and ...

Ultrasound model IDs residual joint inflammation in RA

April 18, 2013
(HealthDay)—A model including ultrasound (US) assessment of the wrist, metacarpophalangeal (MCP), ankle, and metatarsophalangeal (MTP) joints is highly sensitive for detecting B-mode and Doppler joint inflammation in patients ...

Active synovitis with osteitis predicts residual synovitis in RA

February 8, 2017
(HealthDay)—For patients with rheumatoid arthritis (RA) who have clinical response to treatment, active synovitis with osteitis is associated with subsequent residual synovitis (R-synovitis), according to a study published ...

Doctors and rheumatoid arthritis patients differ on perception of disease activity

July 18, 2012
Researchers from Austria have determined that patients with rheumatoid arthritis (RA) and their doctors differ on perception of RA disease activity. The study now available in Arthritis & Rheumatism, a journal of the American ...

Smoking negatively affects response to anti-TNF treatment in patients with rheumatoid arthritis

June 8, 2012
A new study presented today at EULAR 2012, the Annual Congress of the European League Against Rheumatism, reinforces current thinking that smoking negatively affects treatment response in rheumatoid arthritis (RA) patients ...

Recommended for you

Scientists find key proteins control risk of osteoarthritis during aging

February 14, 2018
More than 30 million Americans suffer from osteoarthritis making it one of the most common age-related diseases.

Acute treatment suppresses posttraumatic arthritis in ankle injury

February 7, 2018
A University of Iowa study has identified a method for inhibiting the occurrence of an aggressive form of arthritis that frequently develops following a severe traumatic injury. The preclinical work demonstrates the potential ...

Small molecule could make a big difference for arthritis patients

February 7, 2018
Will there come a time when a patient with arthritis can forgo joint replacement surgery in favor of a shot? Keck School of Medicine of USC scientist Denis Evseenko, MD, PhD, has reason to be optimistic.

Study finds bacteria in milk linked to rheumatoid arthritis

January 30, 2018
A strain of bacteria commonly found in milk and beef may be a trigger for developing rheumatoid arthritis in people who are genetically at risk, according to a new study from the University of Central Florida.

Osteoarthritis could be treated as two diseases, scientists reveal

January 10, 2018
Scientists at The University of Manchester have discovered that most people with osteoarthritis can be subdivided into two distinct disease groups, with implications for diagnosis and drug development.

US arthritis prevalence is much higher than current estimates

November 27, 2017
New research indicates that the prevalence of arthritis in the United States has been substantially underestimated, especially among adults

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.