Cutaneous malignancies can mimic seborrheic keratosis

June 15, 2017

(HealthDay)—Of a sample of lesions deemed seborrheic keratoses clinically, 3.1 percent were histologically diagnosed as malignancies, according to research published online June 7 in the Journal of Cutaneous Pathology.

Tiffany Y. Chen, M.D., from Washington University School of Medicine in St. Louis, and colleagues retrospectively assessed dermatopathology samples from 2015 obtained from private and university locations. A total of 4,361 eligible cases of those with SK or irritated SK (ISK) and no other diagnosis in the clinical data were included in the study.

The researchers found that 86.2 percent of the cases identified as SK or ISK in the were actually SK or ISK; 10.7 percent were non-malignant diagnoses, including dermatofibroma. Overall, 3.1 percent of cases were histologically diagnosed as malignancies. Most of these (67 percent) were in situ or invasive , and 24.3 and 8.8 percent were and melanoma, respectively.

"Clinicians should be aware of this phenomenon. It is important to maintain a high index of suspicion when evaluating SK or ISK from the standpoint that it could possibly be malignant and consider a biopsy, especially if there are any changes over time," the authors write.

Explore further: Renal mass biopsy accurate for small renal masses

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Renal mass biopsy accurate for small renal masses

February 17, 2016
(HealthDay)—Renal mass biopsy is accurate for small renal masses (4 cm or less), according to a study published in the March issue of The Journal of Urology.

Few want to receive skin cancer biopsy results face-to-face

February 15, 2016
(HealthDay)—For patients with suspected malignant melanoma or squamous cell carcinoma, most patients are happy to receive biopsy results by letter or telephone, according to a research letter published online Feb. 8 in ...

Superficial X-ray viable for basal, squamous cell carcinoma

August 6, 2012
(HealthDay) -- Superficial X-ray therapy remains a viable treatment for primary basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) in select patients, according to a study published online July 23 in the Journal ...

Pain and itch may be signs of skin cancer

July 23, 2014
Asking patients if a suspicious skin lesion is painful or itchy may help doctors decide whether the spot is likely to be cancerous, according to a new study headed by Gil Yosipovitch, MD, Chairman of the Department of Dermatology ...

Commonly used painkillers may protect against skin cancer

May 29, 2012
A new study suggests that aspirin and other similar painkillers may help protect against skin cancer. Published early online in Cancer, a peer-reviewed journal of the American Cancer Society, the findings indicate that skin ...

Teledermatology implications for incidental skin CA detection

April 14, 2015
(HealthDay)—An in-person skin examination is important for detection of incidentally-identified skin malignancies, according to a review published in the April issue of the Journal of the American Academy of Dermatology.

Recommended for you

Outdoor light at night linked with increased breast cancer risk in women

August 17, 2017
Women who live in areas with higher levels of outdoor light at night may be at higher risk for breast cancer than those living in areas with lower levels, according to a large long-term study from Harvard T.H. Chan School ...

Scientists develop novel immunotherapy technology for prostate cancer

August 17, 2017
A study led by scientists at The Wistar Institute describes a novel immunotherapeutic strategy for the treatment of cancer based on the use of synthetic DNA to directly encode protective antibodies against a cancer specific ...

Toxic formaldehyde is produced inside our own cells, scientists discover

August 16, 2017
New research has revealed that some of the toxin formaldehyde in our bodies does not come from our environment - it is a by-product of an essential reaction inside our own cells. This could provide new targets for developing ...

Cell cycle-blocking drugs can shrink tumors by enlisting immune system in attack on cancer

August 16, 2017
In the brief time that drugs known as CDK4/6 inhibitors have been approved for the treatment of metastatic breast cancer, doctors have made a startling observation: in certain patients, the drugs—designed to halt cancer ...

Researchers find 'switch' that turns on immune cells' tumor-killing ability

August 16, 2017
Molecular biologists led by Leonid Pobezinsky and his wife and research collaborator Elena Pobezinskaya at the University of Massachusetts Amherst have published results that for the first time show how a microRNA molecule ...

Popular immunotherapy target turns out to have a surprising buddy

August 16, 2017
The majority of current cancer immunotherapies focus on PD-L1. This well studied protein turns out to be controlled by a partner, CMTM6, a previously unexplored molecule that is now suddenly also a potential therapeutic target. ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.