Risk of HPV-linked second cancers up after anal cancer

June 15, 2017

(HealthDay)—Survivors of squamous cell carcinoma of the anus (SCCA) have an elevated risk of human papillomavirus (HPV)-related second primary malignancies (SPMs), according to a study published online June 13 in Cancer.

Rebecca A. Nelson, Ph.D., and Lily L. Lai, M.D., from City of Hope in Duarte, Calif., used population-based data from 1992 through 2012 to identify patients with SCCA and examined their risk of HPV-related SPMs. To determine excess risk, they calculated standardized incidence ratios (SIRs) defined as observed to expected cases.

The researchers found that 416 of the 10,537 patients with SCCA developed HPV-related SPMs, which corresponded to an overall SIR of 21.5. Compared with women, men had higher SIR (35.8 versus 12.8). For a second SCCA, men had markedly higher SIRs than women (127.5 versus 47.0); for oral cavity and pharyngeal cancers, the SIRs were elevated in men and women (3.1 and 4.4, respectively). For sex-specific sites the SIRs were also elevated, with an SIR of 19.6 for male genital cancers and 8.3 for female genital cancers.

"Patients with index SCCA are at an increased risk of subsequent HPV-related SPMs," the authors write. "The elevated risk is most striking in patients with second primary SCCAs; however, the risk of second cancers also appears to be increased in other HPV-related sites."

Explore further: Increased cancer risk for childhood kidney recipients

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Increased cancer risk for childhood kidney recipients

April 5, 2017
(HealthDay)—Childhood kidney recipients have increased cancer risk, according to a study published online March 29 in the American Journal of Transplantation.

Study tracks patterns of US cases of anal canal carcinoma

April 2, 2013
(HealthDay)—Available screening and identification of human papillomavirus likely contributed to the increased incidences of squamous cell carcinoma of the anal canal (SCCA) and anal carcinoma in situ (CIS) after 1997, ...

Index CRC tumor site impacts increased CA risk for survivors

July 15, 2013
(HealthDay)—The location of index colorectal cancer (CRC) affects the incidence of second cancer after CRC, according to a study published online July 15 in Cancer.

Researchers uncover new potential biomarker and therapeutic target for aggressive breast cancer

April 29, 2011
(PhysOrg.com) -- In an analysis of more than 1,300 human breast tissue samples, a team of Stony Brook University School of Medicine researchers discovered a possible role of the squamous cell carcinoma antigen (SCCA) in the ...

Ovarian cancer rates declining in breast cancer survivors

January 8, 2013
(HealthDay)—Primary ovarian cancer incidence is declining in the United States, both among the general population and among breast cancer survivors, according to research published online Jan. 2 in the Journal of Clinical ...

Infection risk up before chronic immune thrombocytopenia

February 4, 2016
(HealthDay)—The incidence of primary chronic immune thrombocytopenia (cITP) is 2.30/100,000 person-years, and incidence is associated with increased risk of infections within the five years before cITP diagnosis, according ...

Recommended for you

Single-cell study in a childhood brain tumor affirms the importance of context

April 20, 2018
In defining the cellular context of diffuse midline gliomas, researchers find the cells fueling their growth and suggest a potential approach to treating them: forcing their cells to be more mature.

Aggressive breast cancer already has resistant tumour cells prior to chemotherapy

April 20, 2018
Difficult to treat and aggressive "triple-negative" breast cancer is chemoresistant even before chemotherapy begins, a new study by researchers from Karolinska Institutet and the University of Texas MD Anderson Cancer Center ...

Mechanism that drives development of liver cancer brought on by non-alcoholic fatty liver disease discovered

April 19, 2018
A team of researchers from several institutions in China has found a mechanism that appears to drive the development of a type of liver cancer not caused by alcohol consumption. In their paper published in the journal Science ...

Discovery adds to evidence that some children are predisposed to develop leukemia

April 19, 2018
St. Jude Children's Research Hospital researchers have made a discovery that expands the list of genes to include when screening individuals for possible increased susceptibility to childhood leukemia. The finding is reported ...

Scientists identify 170 potential lung cancer drug targets using unique cellular library

April 19, 2018
After testing more than 200,000 chemical compounds, UT Southwestern's Simmons Cancer Center researchers have identified 170 chemicals that are potential candidates for development into drug therapies for lung cancer.

Chip-based blood test for multiple myeloma could make bone biopsies a relic of the past

April 19, 2018
The diagnosis and treatment of multiple myeloma, a cancer affecting plasma cells, traditionally forces patients to suffer through a painful bone biopsy. During that procedure, doctors insert a bone-biopsy needle through an ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.