Risk of HPV-linked second cancers up after anal cancer

June 15, 2017

(HealthDay)—Survivors of squamous cell carcinoma of the anus (SCCA) have an elevated risk of human papillomavirus (HPV)-related second primary malignancies (SPMs), according to a study published online June 13 in Cancer.

Rebecca A. Nelson, Ph.D., and Lily L. Lai, M.D., from City of Hope in Duarte, Calif., used population-based data from 1992 through 2012 to identify patients with SCCA and examined their risk of HPV-related SPMs. To determine excess risk, they calculated standardized incidence ratios (SIRs) defined as observed to expected cases.

The researchers found that 416 of the 10,537 patients with SCCA developed HPV-related SPMs, which corresponded to an overall SIR of 21.5. Compared with women, men had higher SIR (35.8 versus 12.8). For a second SCCA, men had markedly higher SIRs than women (127.5 versus 47.0); for oral cavity and pharyngeal cancers, the SIRs were elevated in men and women (3.1 and 4.4, respectively). For sex-specific sites the SIRs were also elevated, with an SIR of 19.6 for male genital cancers and 8.3 for female genital cancers.

"Patients with index SCCA are at an increased risk of subsequent HPV-related SPMs," the authors write. "The elevated risk is most striking in patients with second primary SCCAs; however, the risk of second cancers also appears to be increased in other HPV-related sites."

Explore further: Increased cancer risk for childhood kidney recipients

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Increased cancer risk for childhood kidney recipients

April 5, 2017
(HealthDay)—Childhood kidney recipients have increased cancer risk, according to a study published online March 29 in the American Journal of Transplantation.

Study tracks patterns of US cases of anal canal carcinoma

April 2, 2013
(HealthDay)—Available screening and identification of human papillomavirus likely contributed to the increased incidences of squamous cell carcinoma of the anal canal (SCCA) and anal carcinoma in situ (CIS) after 1997, ...

Index CRC tumor site impacts increased CA risk for survivors

July 15, 2013
(HealthDay)—The location of index colorectal cancer (CRC) affects the incidence of second cancer after CRC, according to a study published online July 15 in Cancer.

Researchers uncover new potential biomarker and therapeutic target for aggressive breast cancer

April 29, 2011
(PhysOrg.com) -- In an analysis of more than 1,300 human breast tissue samples, a team of Stony Brook University School of Medicine researchers discovered a possible role of the squamous cell carcinoma antigen (SCCA) in the ...

Ovarian cancer rates declining in breast cancer survivors

January 8, 2013
(HealthDay)—Primary ovarian cancer incidence is declining in the United States, both among the general population and among breast cancer survivors, according to research published online Jan. 2 in the Journal of Clinical ...

Infection risk up before chronic immune thrombocytopenia

February 4, 2016
(HealthDay)—The incidence of primary chronic immune thrombocytopenia (cITP) is 2.30/100,000 person-years, and incidence is associated with increased risk of infections within the five years before cITP diagnosis, according ...

Recommended for you

Drug suppresses spread of breast cancer caused by stem-like cells

December 12, 2017
Rare stem-like tumor cells play a critical role in the spread of breast cancer, but a vulnerability in the pathway that powers them offers a strategy to target these cells using existing drugs before metastatic disease occurs, ...

MRI scans predict patients' ability to fight the spread of cancer

December 12, 2017
A simple, non-invasive procedure that can indicate how long patients with cancer that has spread to the brain might survive and whether they are likely to respond to immunotherapy has been developed by researchers in Liverpool.

A new weapon against bone metastasis? Team develops antibody to fight cancer

December 11, 2017
In the ongoing battle between cancer and modern medicine, some therapeutic agents, while effective, can bring undesirable or even dangerous side effects. "Chemo saves lives and improves survival, but it could work much better ...

Insights on how SHARPIN promotes cancer progression

December 11, 2017
Researchers at Sanford Burnham Prebys Medical Discovery (SBP) and the Technion in Israel have found a new role for the SHARPIN protein. In addition to being one of three proteins in the linear ubiquitin chain assembly complex ...

Glioblastoma survival mechanism reveals new therapeutic target

December 11, 2017
A Northwestern Medicine study, published in the journal Cancer Cell, has provided new insights into a mechanism of tumor survival in glioblastoma and demonstrated that inhibiting the process could enhance the effects of radiation ...

Liver cancer: Lipid synthesis promotes tumor formation

December 11, 2017
Lipids comprise an optimal energy source and an important cell component. Researchers from the Biozentrum of the University of Basel and from the University of Geneva have now discovered that the protein mTOR stimulates the ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.