Novel retinal lesion seen in some ebola survivors

June 15, 2017

(HealthDay)—A small percentage of Ebola virus disease (EVD) survivors have a novel retinal lesion, according to research published in the July issue of the U.S. Centers for Disease Control and Prevention's Emerging Infectious Diseases.

Paul J. Steptoe, M.B.Ch.B., from the University of Liverpool in the United Kingdom, and colleagues conducted a case-control study in Freetown, Sierra Leone, to examine ocular signs in survivors of EVD. Ophthalmic examination, including widefield retinal imaging, was performed in 82 EVD survivors with ocular symptoms and 105 controls from asymptomatic civilian and military personnel and symptomatic eye clinic attendees.

The researchers found that Snellen visual acuity was ≤6/7.5 in 75.6 and 75.5 percent of EVD survivors and controls, respectively. Unilateral white cataracts were seen in 7.4 and 0 percent of EVD survivors and controls, respectively. In two EVD survivors with cataract but no anterior chamber inflammation, the aqueous humor was polymerase chain reaction-negative for Zaire Ebola virus, allowing surgery to be performed. In 14.6 percent of EVD survivors and no controls there was a novel retinal lesion following anatomical distribution of the optic nerve axons.

"We have documented a novel retinal abnormality in EVD survivors that appears to be specific to EVD, although the proportion in the cohort with the condition is small," the authors write.

Explore further: Ebola survivors have a 'unique' retinal scar

More information: Abstract/Full Text

Related Stories

Ebola survivors have a 'unique' retinal scar

May 15, 2017
Researchers from the University of Liverpool have conducted a study of Ebola survivors to determine if the virus has any specific effects on the back on the eye using an ultra widefield retinal camera.

Vision impairment and eye diseases continue to be concerns for Ebola survivors

January 16, 2017
The acute outbreak of Ebola virus disease (EVD) has subsided in West Africa, but the medical community continues to learn about long-term complications for survivors – including the potential for blinding eye disease. One ...

Ebola may leave some survivors blind

May 5, 2016
(HealthDay)—About one-fifth of Ebola survivors in Sierra Leone developed severe or total vision loss within weeks of being declared free of the virus, a new study finds.

Young CA survivors more often have cost-related nonadherence

June 9, 2017
(HealthDay)—Survivors of adolescent and young adult cancer are more likely to report cost-related medication nonadherence, according to a study published online May 23 in Cancer.

Improving treatments for post-Ebola syndrome sufferers

April 12, 2016
Researchers from the University of Liverpool and the King's Sierra Leone Partnership are to present new findings into post-Ebola syndrome at a major European conference this week.

Post-Ebola syndrome in Sierra Leone

February 25, 2016
Researchers from the University's Institute of Translational Medicine have conducted a study of Ebola survivors to describe the medical problems they continue to have after recovering from the acute disease. The results of ...

Recommended for you

Drug suppresses spread of breast cancer caused by stem-like cells

December 12, 2017
Rare stem-like tumor cells play a critical role in the spread of breast cancer, but a vulnerability in the pathway that powers them offers a strategy to target these cells using existing drugs before metastatic disease occurs, ...

MRI scans predict patients' ability to fight the spread of cancer

December 12, 2017
A simple, non-invasive procedure that can indicate how long patients with cancer that has spread to the brain might survive and whether they are likely to respond to immunotherapy has been developed by researchers in Liverpool.

A new weapon against bone metastasis? Team develops antibody to fight cancer

December 11, 2017
In the ongoing battle between cancer and modern medicine, some therapeutic agents, while effective, can bring undesirable or even dangerous side effects. "Chemo saves lives and improves survival, but it could work much better ...

Insights on how SHARPIN promotes cancer progression

December 11, 2017
Researchers at Sanford Burnham Prebys Medical Discovery (SBP) and the Technion in Israel have found a new role for the SHARPIN protein. In addition to being one of three proteins in the linear ubiquitin chain assembly complex ...

Glioblastoma survival mechanism reveals new therapeutic target

December 11, 2017
A Northwestern Medicine study, published in the journal Cancer Cell, has provided new insights into a mechanism of tumor survival in glioblastoma and demonstrated that inhibiting the process could enhance the effects of radiation ...

Liver cancer: Lipid synthesis promotes tumor formation

December 11, 2017
Lipids comprise an optimal energy source and an important cell component. Researchers from the Biozentrum of the University of Basel and from the University of Geneva have now discovered that the protein mTOR stimulates the ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.