SNMMI Image of the Year: PET and optical imaging for prostate cancer diagnosis and therapy

June 14, 2017, Society of Nuclear Medicine
Technology of dual-labeled PSMA-inhibitors for PET/CT imaging and fluorescence-guided intraoperative identification of metastases. This work might help to establish a new treatment regimen for more precise and sensitive pre-, intra- and post-therapeutic detection of prostate cancer. Credit: A. Baranski, M. Schäfer, U. Bauder-Wüst, M. Roscher, J. Schmidt, E. Stenau, L. Maier-Hein, M. Eder, K. Kopka, German Cancer Research Center, Heidelberg, Germany; T. Simpfendörfer, B. Hadaschik, U. Haberkorn, Heidelberg University Hospital, Heidelberg, Germany; PET-image: Afshar-Oromieh et al., EJNMMI 2013; 40(4); STED-image: J. Matthias, German Cancer Research Center.

In the battle against metastatic prostate cancer, the removal of lymph node metastases using image-guided surgery may have a high clinical impact on outcomes. Researchers at the 2017 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging (SNMMI) demonstrated preclinically that dual-labeled PSMA-inhibitors based on PSMA-11 enhance preoperative staging, using PET/CT followed by fluorescence-guided surgery. The combined approach results in more accurate detection of PSMA-positive tumor lesions.

Each year, SNMMI chooses an image that exemplifies the most promising advances in the field of and . The state-of-the-art technologies captured in these images demonstrate the capacity to improve patient care by detecting disease, aiding diagnosis, improving clinical confidence and providing a means of selecting appropriate treatments. This year, the SNMMI Image of the Year was chosen from more than 2,000 abstracts submitted to the meeting and voted on by reviewers and the society leadership.

The 2017 Image of the Year goes to a team of researchers from the German Cancer Research Center (DKFZ) and University Hospital in Heidelberg. The image clearly demonstrates how combining the advantages of 68Ga-PSMA PET and intraoperative gamma and fluorescence imaging results in better tumor identification before and during surgery.

"We are deeply honored to receive this award, and I would like to thank all team members who contributed to this interdisciplinary work," said Ann-Christin Baranski. "As resection of has considerable impact on the outcome of patients, the aim of our study is to improve the intraoperative accuracy of detecting PSMA-positive tumor lesions."

"There has been a huge effort to improve care of prostate patients using molecular imaging," stated Satoshi Minoshima, MD, PhD, chair of the SNMMI Scientific Program Committee and SNMMI vice president-elect. "The study presented by Ann-Christin Baranski clearly demonstrates that the combined PET imaging, gamma detection, and optical imaging can help not only pre-operative staging of the disease but also intra-operative guidance of metastatic lymph node dissection. We anticipate that such hybrid cancer detection methods will become prevalent in the near future and contribute significantly to the care and management of prostate cancer patients."

Explore further: Targeted photodynamic therapy shown highly effective against prostate cancer

More information: "Preclinical evaluation of dual-labeled PSMA-inhibitors for the diagnosis and therapy of prostate cancer." SNMMI's 64th Annual Meeting, June 10-14, 2017, Denver, Colo.

Related Stories

Targeted photodynamic therapy shown highly effective against prostate cancer

June 12, 2017
Researchers presenting a preclinical study at the 2017 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging (SNMMI) demonstrated the efficacy and optimal dose for targeted photodynamic therapy (tPDT) to ...

SNMMI image of the year: Theranostic drug unites imaging and therapy for prostate cancer

June 8, 2015
A novel molecular imaging technology not only detects prostate cancer that has spread throughout the body, but also provides a potent and minimally invasive method of radiotherapy, reveal researchers at the 2015 Society of ...

PET/CT imaging of prostate cancer proves accurate biopsy guide

June 15, 2016
Prostate cancer is the leading cancer among men, second only to skin cancer. With surgical removal at the frontline of defense, oncologists are considering prostate-specific molecular imaging at the point of initial biopsy ...

A better way to image metastatic prostate cancer

January 27, 2016
Conventional imaging methods have limited sensitivity for detecting metastatic prostate cancer. With appropriate, timely treatment vital to survival and quality of life, better imaging has been an ongoing goal.

Dual-agent PET/MR with time of flight detects more cancer

June 14, 2017
Simultaneous injections of the radiopharmaceuticals fluorine-18 fluorodeoxyglucose (18F-FDG) and 18F-sodium fluoride (18F-NaF) followed by quantitative scanning significantly improves image quality and detection of bone metastases ...

Immuno-PET shows promise for detecting and treating pancreatic tumors

June 13, 2017
Pancreatic cancer is associated with bleak five-year survival rates and limited treatment options, but new research is offering hope. A first-in-human study presented at the 2017 Annual Meeting of the Society of Nuclear Medicine ...

Recommended for you

Ketogenic diet reduces body fat in women with ovarian or endometrial cancer

September 19, 2018
Women with ovarian or endometrial cancer who followed the ketogenic diet for 12 weeks lost more body fat and had lower insulin levels compared to those who followed the low-fat diet recommended by the American Cancer Society, ...

Researchers find adult stem cell characteristics in aggressive cancers from different tissues

September 19, 2018
UCLA researchers have discovered genetic similarities between the adult stem cells responsible for maintaining and repairing epithelial tissues—which line all of the organs and cavities inside the body—and the cells that ...

Colon cancer is caused by bacteria and cell stress

September 19, 2018
Researchers at Technical University Munich have reported findings related to the development of colon cancer. "We originally wanted to study the role of bacteria in the intestines in the development of intestinal inflammation," ...

Eating foods with low nutritional quality ratings linked to cancer risk in large European cohort

September 18, 2018
The consumption of foods with higher scores on the British Food Standards Agency nutrient profiling system (FSAm-NPS), reflecting a lower nutritional quality, is associated with an increased risk of developing cancer, according ...

CRISPR screen reveals new targets in more than half of all squamous cell carcinomas

September 18, 2018
A little p63 goes a long way in embryonic development—and flaws in p63 can result in birth defects like cleft palette, fused fingers or even missing limbs. But once this early work is done, p63 goes silent, sitting quietly ...

Could the zika virus fight the brain cancer that killed john McCain?

September 18, 2018
(HealthDay)—Preliminary research in mice suggests that the Zika virus might be turned from foe into friend—enlisted to curb deadly glioblastoma brain tumors.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.