Tryptophan may be marker for diabetic nephropathy

June 29, 2017

(HealthDay)—For patients with diabetes and chronic kidney disease (CKD), a lower level of tryptophan (Trp) is associated with rapid decline in estimated glomerular filtration rate (eGFR), according to a study published online June 26 in the Journal of Diabetes Investigation.

Chien-An Chou, from Chang Gung University in Taoyuan, Taiwan, and colleagues enrolled 52 patients with diabetes at various stages of CKD. The authors measured serum levels of 175 metabolites, and selected those with significant difference in advancing CKD stages. Serial renal function change was followed for 12 months, and the outcome of renal function with each selected metabolite according to the occurrence of a of eGFR was compared.

The researchers found that 26 metabolites were significantly associated with CKD severity. There was a significant association for Trp with the event of rapid decline in eGFR (P = 0.036). The most valuable predictive value was seen for serum concentration of Trp below 44.20 µM, with 55.6 percent sensitivity and 87 percent specificity.

"Trp may be regarded as a potential prognostic marker for diabetic nephropathy," the authors write.

Explore further: Metabolites linked to renal decline, time to ESRD in T1DM

More information: Abstract
Full Text

Related Stories

Metabolites linked to renal decline, time to ESRD in T1DM

January 19, 2017
(HealthDay)—Serum levels of seven modified metabolites are associated with renal function decline and time to end-stage renal disease (ESRD) among patients with type 1 diabetes (T1D), according to a study published online ...

Decline in eGFR mainly linear in type 1 diabetes

September 22, 2016
(HealthDay)—For patients with type 1 diabetes, the decline of estimated glomerular filtration rate (eGFR) is mainly linear, according to a study published online Sept. 19 in Diabetes Care.

Insulin sensitivity is key renal marker in youth with T2DM

August 7, 2014
(HealthDay)—Among adolescents with type 2 diabetes, insulin sensitivity is an important marker of renal health, according to research published online July 28 in Diabetes Care.

Clinical validation results confirm PromarkerD can predict diabetic kidney disease better than any current measure

June 13, 2017
Proteomics International Laboratories Ltd. has announced results from the clinical validation study showing that its PromarkerD blood test can predict the onset of diabetic kidney disease (DKD) better than any current measure.

Low HDL-C, high TG increase risk for diabetic kidney disease

October 12, 2016
(HealthDay)—For patients with diabetes, low high-density lipoprotein cholesterol (HDL-C) and high triglyceride (TG) levels are associated with increased risk of diabetic kidney disease (defined as low estimated glomerular ...

sRAGE linked to risk of incident diabetic nephropathy

June 22, 2017
(HealthDay)—Serum levels of soluble receptor for advanced glycation end products (sRAGE) are associated with the risk of developing incident diabetic nephropathy (DN) in individuals with type 1 diabetes, according to a ...

Recommended for you

Study reveals the current rates of diagnosed type 1 and type 2 diabetes in American adults

September 18, 2018
A new study from the University of Iowa finds that type 2 diabetes remains overwhelmingly the most common type of diabetes diagnosed in American adults who have the disease.

Research reveals link between immunity, diabetes

September 14, 2018
When it comes to diet-induced obesity, your immune system is not always your friend.

BPA exposure in U.S.-approved levels may alter insulin response in non-diabetic adults

September 14, 2018
In a first study of its kind study, researchers have found that a common chemical consumers are exposed to several times a day may be altering insulin release. Results of the study, led by scientists at the University of ...

High blood sugar during pregnancy ups risk of mother's type 2 diabetes, child's obesity

September 11, 2018
Mothers with elevated blood glucose during pregnancy—even if not high enough to meet the traditional definition of gestational diabetes—were significantly more likely to have developed type 2 diabetes a decade after pregnancy ...

Want to avoid type 2 diabetes? Eat more whole grains

September 11, 2018
(HealthDay)—It may seem counterintuitive, but eating bread, pasta and cereal may actually help prevent type 2 diabetes, as long as those foods are made from whole grains, new research suggests.

Exercise could delay progression of type 1 diabetes when first diagnosed

September 5, 2018
The findings of a study led by the University of Birmingham suggests that exercise during the first few months of diagnosis of type 1 diabetes could delay the progression of the condition.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.