Low HDL-C, high TG increase risk for diabetic kidney disease

Low HDL-C, high TG increase risk for diabetic kidney disease

(HealthDay)—For patients with diabetes, low high-density lipoprotein cholesterol (HDL-C) and high triglyceride (TG) levels are associated with increased risk of diabetic kidney disease (defined as low estimated glomerular filtration rate [eGFR], an eGFR reduction >30 percent, and/or albuminuria), according to a study published online Oct. 4 in Diabetes Care.

Giuseppina T. Russo, M.D., Ph.D., from the University of Messina in Italy, and colleagues conducted an observational retrospective study involving 15,362 patients attending Italian diabetes centers with baseline eGFR ≥60 mL/min/1.73 m², normoalbuminuria, and ≤130 mg/dL completing a four-year follow-up.

The researchers found that TG ≥150 mg/dL correlated with increases in the risk of low eGFR (26 percent), eGFR reduction >30 percent (29 percent), albuminuria (19 percent), and developing one abnormality (35 percent). HDL-C <40 mg/dL in men and <50 mg/dL in women correlated with increases in the risk of low eGFR (27 percent), eGFR reduction >30 percent (28 percent), albuminuria (24 percent), and developing one abnormality (44 percent). The correlations persisted when TG and HDL-C were assessed as continuous variables, and were attenuated by adjustment for multiple confounding variables.

"In a large population of outpatients with diabetes, low HDL-C and high TG levels were independent risk factors for the development of over four years," the authors write.


Explore further

Albuminuria linked to higher nighttime SBP in hypertension

More information: Full Text (subscription or payment may be required)
Journal information: Diabetes Care

Copyright © 2016 HealthDay. All rights reserved.

Citation: Low HDL-C, high TG increase risk for diabetic kidney disease (2016, October 12) retrieved 6 December 2019 from https://medicalxpress.com/news/2016-10-hdl-c-high-tg-diabetic-kidney.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
 shares

Feedback to editors

User comments