Aspirin responsiveness can change after bariatric surgery

July 20, 2017

(HealthDay)—The effects of aspirin on platelet inhibition may be more potent after bariatric surgery, according to a study published online July 14 in Cardiovascular Therapeutics.

Nicholas B. Norgard, Pharm.D., from the University at Buffalo in New York, and colleagues administered two seven-day courses of 81 mg aspirin in 15 patients scheduled to undergo bariatric surgery. The courses were administered before surgery and three months after surgery. Before and after each aspirin course, they measured platelet aggregation. The change in on-treatment aspirin reactive units (ARUs) pre- and post-surgery was measured as the primary end point.

The researchers found that off-treatment ARU was significantly reduced post-bariatric surgery versus pre-surgery levels (602±59 versus 531±78; P = 0.035). After surgery there was also a significant reduction in on-aspirin platelet reactivity (469±60 versus 432±143; P = 0.03). The extent of weight loss was significantly correlated with the degree of improvement in on-aspirin platelet reactivity (r² = 0.49; P = 0.024). Compared with normal-weighted subjects, obese patients had significantly higher pre-surgery on-aspirin platelet reactivity (469±60 versus 419±52; P = 0.016), which was reduced to baseline after (432±63 versus 419±52; P = 0.54).

"Aspirin-induced platelet inhibition may be more potent following ," the authors write. "The mechanisms behind this improvement require further investigation."

Explore further: Aspirin enhances platelet isoprostanes in type 2 diabetes

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Aspirin enhances platelet isoprostanes in type 2 diabetes

March 23, 2012
(HealthDay) -- For patients with type 2 diabetes mellitus (T2DM) who are treated with aspirin, isoprostanes are overproduced, which is linked with enhanced platelet recruitment, according to a study published online March ...

Pre-pregnancy bariatric surgery ups risk of abdominal surgery

April 18, 2017
(HealthDay)—Bariatric surgery is associated with an increased risk of abdominal surgery during subsequent pregnancy, according to a study published in the May issue of Obstetrics & Gynecology.

Dipyrone negates aspirin's antiplatelet effect

August 22, 2013
(HealthDay)—There is an unfavorable pharmacological drug interaction between the non-narcotic analgesic dipyrone and aspirin in patients with coronary artery disease (CAD), according to research published online Aug. 14 ...

OK to continue aspirin therapy up to pancreatic surgery

August 1, 2013
(HealthDay)—Patients on aspirin therapy do not have higher rates of perioperative bleeding, transfusion, or major procedure-related complications following elective pancreatic surgery, according to research published online ...

Bedtime aspirin may reduce risk of morning heart attack

November 19, 2013
Taking aspirin at bedtime instead of in the morning might reduce acute heart events, according a new study presented at the American Heart Association's Scientific Sessions 2013.

HRS: Bariatric surgery may prevent A-fib onset in obese

May 8, 2014
(HealthDay)—Bariatric surgery may prevent the development of atrial fibrillation in morbidly obese patients, according to research presented at the annual meeting of the Heart Rhythm Society, held from May 7 to 10 in San ...

Recommended for you

Surprise finding—for very sick elderly, lighter sedation won't drop risk of postoperative delirium, study suggests

August 13, 2018
Johns Hopkins Medicine researchers say a study designed to see if reducing the amount of anesthesia reduces the risk of postoperative delirium in older patients surprisingly found that lighter sedation failed to do so in ...

Kidney transplant chains more effective in saving lives

August 9, 2018
New research from the UBC Sauder School of the Business has found that transplant societies which prioritize kidney transplant chains over kidney exchanges can increase the total number of transplants, thereby saving more ...

Surgical mesh implants may cause autoimmune disorders

July 31, 2018
Surgical mesh implants, often used for hernia or gynecological repair, may be the reason so many patients report symptoms of an autoimmune disorder, according to a University of Alberta rheumatologist.

Surgeons discuss options when the risks of surgery may be too high

July 27, 2018
In an essay published July 26 in the New England Journal of Medicine, Ira Leeds, M.D., research fellow, and David Efron, M.D., professor of surgery, both of the Johns Hopkins University School of Medicine, along with their ...

Blood plasma during emergency air transport saves lives

July 25, 2018
Two units of plasma given in a medical helicopter on the way to the hospital could increase the odds of survival by 10 percent for traumatically injured patients with severe bleeding, according to the results of a national ...

The dark side of antibiotic ciprofloxacin

July 25, 2018
The use of ciprofloxacin and other antibiotics of the class of fluoroquinolones may be associated with disruption of the normal functions of connective tissue, including tendon rupture, tendonitis and retinal detachment. ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.