Study suggests ending opioid epidemic will take years

July 20, 2017 by Kimberly Reich, University of Virginia
Credit: University of Virginia

The question of how to stem the nation's opioid epidemic now has a major detailed response. A new study chaired by University of Virginia School of Law Professor Richard Bonnie provides extensive recommendations for curbing the problem.

Drug overdoses are the leading cause of unintentional death in the United States, and opioids are the chief contributor. Between 2011 and 2015, overdose deaths from illicit opioids increased from 7,019 to 19,884—almost threefold.

Bonnie chaired the study for the National Academies of Sciences, Engineering and Medicine.

"This is an urgent matter," he said. "Ninety people die every day of an overdose. We need to muster an 'all hands on deck' response to it, and the response needs to be sustained."

An ad hoc committee of pain-management, opioid-misuse and other public health experts, including UVA Law Professor Margaret Riley, convened in March 2016 at the request of the Food and Drug Administration to examine two challenges that fuel the epidemic: the need for opioids to treat pain and the need to reduce harms when the drugs are not used as intended. The committee's analysis and recommendations were presented to the FDA and at several Congressional briefings Wednesday and were released to the public on Thursday.

Release of the Committee on Pain Management and Regulatory Strategies to Address Prescription Opioid Abuse report was accompanied by an invited "viewpoint" column in the Journal of the American Medical Association.

In the report, the committee urges efforts to educate prescribers, patients and the general public on alternatives to opioids, as well as the risk factors of their use.

Reducing the prescribing of opioids has already begun, Bonnie said. But when addicted patients are taken off , they often seek and find substitutes in the illegal market. The number of deaths due to heroin overdose is steeply going up in tandem with the efforts to reduce prescribing, the report shows.

"The epidemic has gotten more complicated because of the intersection of legal and illegal markets," Bonnie said. The increased use of illegal fentanyl, which is more potent and more dangerous than heroin, is very alarming."

The committee also recommends using evidence-based medical treatment for almost 2.6 million people who have "opioid use disorder" and emphasizes that providing access to treatment is an "ethical imperative."

But medications for treating addiction can be expensive. Congress' consideration of expanding Medicaid to help combat the problem is vitally important, Bonnie said.

"It's actually quite heartening that we have bipartisan support for doing something about this problem," he said.

The report also urges states to remove financial and legal impediments to access to naloxone, the drug used to save the lives of people who have overdosed.

The committee recommends additional research into non-addictive analgesic alternatives to opioids and non-pharmaceutical options such as massage therapy and yoga.

Additionally, an expansion of the FDA's regulatory vision will aid the agency in systematically considering public health concerns when making their decisions, Bonnie said. To this end, the committee has recommended specific ways in which the agency can incorporate concerns about the risk of addiction, overdose, diversion of drugs from the health care system and other harms into their decision-making process.

One of those ways is for the FDA to conduct a systematic review of all opioids currently on the market.

"We need a broader regulatory approach and more aggressive monitoring of what happens in practice after the drugs are on the market," Bonnie said.

The problem won't be solved overnight, he said.

"It took about 20 years for this epidemic to get to the point where we are," Bonnie said. "And it's going to take many years to unwind it. So we really need to stay on this. It can't be one of those things with a short political attention span. It's very serious and it's going to be very serious for a long time."

Explore further: Strategy to battle opioid epidemic encourages multilevel approach

More information: Richard J. Bonnie et al. Both Urgency and Balance Needed in Addressing Opioid Epidemic, JAMA (2017). DOI: 10.1001/jama.2017.10046

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BubbaNicholson
1 / 5 (2) Jul 21, 2017
The opioid epidemic can be over in two weeks. 250mg of healthy adult male facial skin surface lipid liquid pheromone taken by mouth cures opioid addiction instantly without withdrawal symptoms. The liquid "face grease" pheromone, usually passed in kissing, has 735 chemical components which have stereochemistries typical of pheromones in many other species. An airborne sub-pheromone evaporates off the skin surface liquid and when it is aggregated in one place, the airborne sub-pheromone vapor becomes emotionally toxic causing artificial stupidity, artificial arrogance, artificial distrust, artificial suspicion, and artificial superstition. Perhaps these various emotional responses to the airborne sub-pheromone result from different components being evaporated? That is highly likely as every man's face grease is chemically unique to him for proportions of the 735 chemicals vary.
Use respirators, fume hoods, oscillating fans, isolate treated addicts 40 days.
Captain Stumpy
not rated yet Jul 21, 2017
@pseudoscience cult fraud bubba
The opioid epidemic can be over in two weeks. 250mg of healthy adult male facial skin surface lipid liquid pheromone taken by mouth cures opioid addiction instantly without withdrawal symptoms
repeating a lie doesn't make it more true unless you're trying to beat a false belief into a cult member

repeating a lie that is proven false by science is called fraud, especially when you can't substantiate your claims with evidence and you're attempting to claim medical license, training or association

just because you can post your lie to an unmoderated news aggregate doesn't mean it's valid, validated or that it's "true" because it's not deleted

it only means the site doesn't moderate or require evidence to make stupid claims

there is no robust bioassay-led evidence for the widely published claims that four steroid molecules are human pheromones

http://rspb.royal...full.pdf

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