Biden administration calls for greater access to overdose antidote
The White House on Wednesday launched a nationwide call for more training and better access to the lifesaving opioid overdose drug naloxone.
Mar 13, 2024
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The White House on Wednesday launched a nationwide call for more training and better access to the lifesaving opioid overdose drug naloxone.
Mar 13, 2024
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Health providers and addiction experts warn the funding structure is unstable for a California initiative that steers patients with substance use disorder into long-term treatment after they are discharged from emergency ...
Mar 12, 2024
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The Oregon Poison Center at Oregon Health & Science University is reporting a dramatic increase in cases of young children exposed to fentanyl. The poison center managed 16 cases of illicit fentanyl exposure in children younger ...
Mar 7, 2024
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In a new study, researchers have found that replacing long-acting with immediate-release opioids after total knee replacement surgery resulted in comparable pain management but less nausea-medication usage and less need for ...
Mar 6, 2024
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Primary care pediatricians feel less prepared to manage adolescents' opioid use disorder (OUD) compared with other substances, according to a research letter published online in JAMA Pediatrics.
Mar 1, 2024
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A study led by Ryan W. Logan, Ph.D., professor of psychiatry and neurobiology, has found mutations in key brain cells among individuals with chronic opioid use that could shift how we think about treatment strategies for ...
Mar 1, 2024
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US officials announced Thursday an agreement with Endo Health Solutions (EHSI) to settle civil and criminal claims over the mislabeling of its pain reliever drug Opana, which has contributed to the opioid epidemic.
Feb 29, 2024
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Medications to treat opioid use disorder, including methadone and buprenorphine, have been shown to save lives, cutting overdose deaths by up to 60% and reducing the transmission of HIV by offering a safe alternative to injection ...
Feb 29, 2024
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The weight of the opioid crisis is heavy.
Feb 27, 2024
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University of Queensland researchers and international collaborators have found a deadly synthetic drug in wastewater in the United States—the first such detection globally.
Feb 23, 2024
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An opioid is a psychoactive chemical that works by binding to opioid receptors, which are found principally in the central and peripheral nervous system and the gastrointestinal tract. The receptors in these organ systems mediate both the beneficial effects and the side effects of opioids.
Opioids are among the world's oldest known drugs; the use of the opium poppy for its therapeutic benefits predates recorded history. The analgesic (painkiller) effects of opioids are due to decreased perception of pain, decreased reaction to pain as well as increased pain tolerance. The side effects of opioids include sedation, respiratory depression, constipation, and a strong sense of euphoria. Opioids can cause cough suppression, which can be both an indication for opioid administration or an unintended side effect. Opioid dependence can develop with ongoing administration, leading to a withdrawal syndrome with abrupt discontinuation. Opioids are well known for their ability to produce a feeling of euphoria, motivating some to recreationally use opioids.
Although the term opiate is often used as a synonym for opioid, the term opiate is properly limited to the natural alkaloids found in the resin of the opium poppy (Papaver somniferum). In some definitions, the semi-synthetic substances that are directly derived from the opium poppy are considered to be opiates as well, while in other classification systems these substances are simply referred to as semi-synthetic opioids.
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