Call for global action on life-threatening fungal infections

University of Manchester researchers have co-ordinated a 'first of its kind' series, published today in the prestigious journal The Lancet Infectious Diseases.

The gives new insights into the breadth of fungal diseases and a call to action for world bodies to prevent millions of infections each year.

Killing over 1.5 million and affecting over a billion people, fungal diseases have been the most neglected topic by public health authorities. However, most deaths from fungal diseases are avoidable.

Most serious are 'hidden', occurring as a consequence of other health problems such as asthma, AIDS, cancer, organ transplant and corticosteroid therapies.

All require specialised testing for diagnosis, and delays or missed diagnosis often leads to death, serious chronic illness or blindness.

As a result the Journal has decided to signal an end to this neglect by commissioning an authoritative series of articles, coving almost all aspects of fungal diseases.

The series focuses on the global inequalities in treatment. Professors David Denning and Juan Luis Rodriguez Tudela from The University of Manchester and the Global Action Fund for Fungal Infections, co-ordinated the eight paper series commented:

Professor Denning said: "The massive advances in fungal and understanding over the last two decades should have resulted in much better outcomes – but sadly not in many countries.

Profesor Juan Luis Rodriguez Tudela said: "Improvements in patient outcomes require changes in all part of the health care 'ecosystem', notably clinical training, access to and resource for fungal diagnostics, access to affordable antifungal therapy. A major public health response is called for."

According to the researchers, there has been a complete absence of proposals or commentary on integration of fungal diseases into health care systems.

This is addressed by Professor Donald Cole of the Dalla Lana School of Public Health, University of Toronto who calls for a 'combined health systems and approaches' and provides examples from Mozambique, Kenya, India, and South Africa.

Authors of the papers in the series have been brought together from six continents

They tackle fungal infections in AIDS, in cancer, after TB, in asthma, after transplantation and major abdominal surgery, in critical care in the rare patients with immunodeficiencies and notably the WHO 'neglected tropical fungal diseases' mycetoma and chromoblastomycosis.

Outbreaks of occur frequently and these are highlighted in one article.

Another addresses antifungal resistance – like anti-bacterial resistance an increasing problem requiring many radical solutions and new antifungal drugs.

Professor Denning added: "The evidence gathered in this article series shows not only the scale of the global problem but also that hundreds of thousands of deaths a year could be avoided.

"The expertise is available, now it just needs government and international action to make it a reality."

The series will be published in The Lancet Infectious Diseases on 31 July 2017.

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Journal information: Lancet Infectious Diseases

Citation: Call for global action on life-threatening fungal infections (2017, August 1) retrieved 13 November 2019 from
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