Substance in coffee delays onset of diabetes in laboratory mice

September 6, 2017, American Chemical Society
Credit: American Chemical Society

In recent years, researchers have identified substances in coffee that could help quash the risk of developing Type 2 diabetes. But few of these have been tested in animals. Now in study appearing in ACS' Journal of Natural Products, scientists report that one of these previously untested compounds appears to improve cell function and insulin sensitivity in laboratory mice. The finding could spur the development of new drugs to treat or even prevent the disease.

Some studies suggest that drinking three to four cups of coffee a day can reduce the risk of developing Type 2 diabetes, a disease that afflicts nearly 30 million Americans. Initially, scientists suspected that caffeine was responsible for this effect. But later findings discounted this possibility, suggesting that other substances in coffee may have a more important role. In a previous laboratory study, Fredrik Brustad Mellbye, Søren Gregersen and colleagues found that a compound in coffee called cafestol increased insulin secretion in pancreatic cells when they were exposed to glucose. Cafestol also increased in muscle cells just as effectively as a commonly prescribed antidiabetic drug. In this new study, the researchers wanted to see if cafestol would help prevent or delay the onset of Type 2 diabetes in mice.

The researchers divided mice that are prone to develop Type 2 diabetes into three groups. Two of the groups were fed differing doses of cafestol. After 10 weeks, both sets of cafestol-fed mice had lower and improved insulin secretory capacity compared to a control group, which was not given the compound. Cafestol also didn't result in hypoglycemia, or , a possible side effect of some antidiabetic medications. The researchers conclude that daily consumption of cafestol can delay the onset of Type 2 diabetes in these mice, and that it is a good candidate for drug development to treat or prevent the disease in humans.

Explore further: Where does coffee stand in your health?

More information: Fredrik Brustad Mellbye et al. Cafestol, a Bioactive Substance in Coffee, Has Antidiabetic Properties in KKAy Mice, Journal of Natural Products (2017). DOI: 10.1021/acs.jnatprod.7b00395

Related Stories

Where does coffee stand in your health?

April 13, 2013
We are often asked whether coffee is good or bad for the health. The answer is both good and bad.

A dual-functional GLP-1 analogue may improve insulin sensitivity and help fight diabetes

May 11, 2017
According to research published online in The FASEB Journal, scientists have discovered a dual peptide called "PGLP-1" that promotes insulin secretion and inhibits gluconeogenesis (a metabolic process that produces glucose). ...

Sugar sponges sop up and release glucose as needed

May 31, 2017
Many diabetes patients must inject themselves with insulin, sometimes several times a day, while others take medications orally to control blood sugar. The injections, as well as the side effects from both regimens, can be ...

Recommended for you

Wound care revolution: Put away your rulers and reach for your phone

December 18, 2018
Monitoring a wound is critical, especially in diabetic patients, whose lack of sensation due to nerve damage can lead to infection of a lesion and, ultimately, amputation. Clinicians and healthcare professionals at the McGill ...

Researchers study abnormal blood glucose levels of discharged patients

December 14, 2018
University of Minnesota Medical School researchers decided to delve into an area where little data currently exists. They wanted to know what happens after these patients with abnormal blood glucose measurements are discharged? ...

Researchers zero in on potential therapeutic target for diabetes, associated diseases

December 14, 2018
A recent study led by researchers in Texas A&M University's department of nutrition and food science shows how a novel regulatory mechanism serves as an important biomarker for the development of diabetes, as well as a potential ...

Does diabetes damage brain health?

December 14, 2018
(HealthDay)—Diabetes has been tied to a number of complications such as kidney disease, but new research has found that older people with type 2 diabetes can also have more difficulties with thinking and memory.

Researchers have found that incidence of heart failure was around two-fold higher in people with diabetes

December 11, 2018
Researchers have found that incidence of heart failure was around two-fold higher in people with diabetes.

Millions of low-risk people with diabetes may be testing their blood sugar too often

December 10, 2018
For people with Type 2 diabetes, the task of testing their blood sugar with a fingertip prick and a drop of blood on a special strip of paper becomes part of everyday life.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.