Ebola vaccine tests hailed a success

October 9, 2017
The Ebola virus, isolated in November 2014 from patient blood samples obtained in Mali. The virus was isolated on Vero cells in a BSL-4 suite at Rocky Mountain Laboratories. Credit: NIAID

Experts at St George's, University of London, have reported that an Ebola vaccine is safe for children as well as adults and produces an immune response.

The worst Ebola virus outbreak in history ended in 2016 after infecting 28,600 people and killing about 11,300 worldwide.

The outbreak led to urgent action by medical experts across the world to combat this devastating disease; including the setting up of trials of vaccines to stop the disease taking hold.

This global commitment to develop a against the disease suggested eight options, out of a starting pool of 15 candidates, should be evaluated in clinical trials worldwide by the end of 2015.

Professor Sanjeev Krishna, of St George's University of London's Institute for Infection and Immunity, said: "An unprecedented Ebola outbreak showed how it is possible for academics, non-governmental organisations, industry and funders to work effectively together very quickly in times of medical crisis. The results of the trial show how a vaccine could best be used to tackle this terrible disease effectively.

"We need a system of specialists, and organisers that maintains vigilance against outbreak diseases like Ebola.

"We should continue to improve ways to make, evaluate and deliver vaccines when they are needed, often in parts of the world lacking in infrastructure for diagnosing infections and providing treatments."

He explained that considering the persistent replication of the vaccine which is called rVSV-ΔGP-ZEBOV in children and adolescents, further studies investigating lower doses in this population are warranted.

The vaccine contains a non-infectious portion of a gene from the Zaire Ebola virus. The St George's researchers worked with colleagues on a in Gabon.

In addition, lower vaccine doses should be considered when boosting individuals with pre-existing antibodies to Ebolavirus glycoprotein, a finding that has emerged after the vaccine was tested in a country that has experienced Ebolavirus outbreaks in the past.

The vaccine was one of two being examined as a 'candidate' option by the World Health Organisation to identify urgently a vaccine to combat the Ebola virus outbreak in West Africa.

The clinical trial was led by colleagues at University of Tübingen in Germany, coordinated by Professor Peter Kremsner with their partner institute CERMEL in Lambaréné, Gabon.

Professor Krishna was among a consortium of experts called VEBCON convened by the WHO in August 2014 in Geneva to discuss solutions and strategies for combatting the EVD crisis.

He acted as a scientific advisor to the new studies in Gabon, He is also affiliated with the Institute of Tropical Medicine in Tübingen and has carried out collaborative work for many years in Lambaréné.

Explore further: WHO chief praises Guineans for help with Ebola vaccine

More information: "Safety and immunogenicity of rVSVΔG-ZEBOVGP Ebola vaccine in adults and children in Lambareanea, Gabon: A phase I randomised trial," PLOS Medicine (2017) doi.org/10.1371/journal.pmed.1002402

Related Stories

WHO chief praises Guineans for help with Ebola vaccine

May 4, 2017
The head of the World Health Organization is praising Guineans for their role in helping to develop a vaccine against the deadly Ebola virus.

Ebola vaccines provide immune responses after one year

March 14, 2017
Immune responses to Ebola vaccines at one year after vaccination are examined in a new study appearing in the March 14 issue of JAMA.

Ebola vaccine—Promising phase I trials

May 3, 2016
The clinical phase I trial of a potential vaccine against the dreaded Ebola virus has been successfully completed at four partner sites in Africa and Europe. The safety of the tested vaccine 'rVSV-ZEBOV', which induces persistent ...

DR Congo authorises trial of experimental Ebola vaccine

May 29, 2017
The Democratic Republic of Congo has approved using an experimental Ebola vaccine to combat an outbreak of the virus in the northeast, the government said Monday.

Global Vaccine promises $5 million to develop Ebola vaccine

January 20, 2016
The global vaccine alliance GAVI says it will donate $5 million toward developing the leading Ebola vaccine, hoping that it will be approved by a regulator by the end of 2017.

Two-vaccine Ebola regimen shows promise in early-stage clinical trial

April 19, 2016
An immunization regimen using two Ebola vaccine candidates was safe and well-tolerated and induced an immune response in healthy adult volunteers in a Phase 1 clinical trial. Results from the study are described in the April ...

Recommended for you

Aging impairs innate immune response to flu

December 13, 2017
Aging impairs the immune system's response to the flu virus in multiple ways, weakening resistance in older adults, according to a Yale study. The research reveals why older people are at increased risk of illness and death ...

Drug blocks Zika, other mosquito-borne viruses in cell cultures

December 12, 2017
If there was a Mafia crime family of the virus world, it might be flaviviruses.

Study seeks to aid diagnosis, management of catatonia

December 11, 2017
Catatonia, a syndrome of motor, emotional and behavioral abnormalities frequently characterized by muscular rigidity and a trance-like mental stupor and at times manifesting with great excitement or agitation, can occur during ...

New compound stops progressive kidney disease in its tracks

December 7, 2017
Progressive kidney diseases, whether caused by obesity, hypertension, diabetes, or rare genetic mutations, often have the same outcome: The cells responsible for filtering the blood are destroyed. Reporting today in Science, ...

New Lyme disease tests could offer quicker, more accurate detection

December 7, 2017
New tests to detect early Lyme disease - which is increasing beyond the summer months -could replace existing tests that often do not clearly identify the infection before health problems occur.

Spinal tap needle type impacts the risk of complications

December 6, 2017
The type of needle used during a lumbar puncture makes a significant difference in the subsequent occurrence of headache, nerve irritation and hearing disturbance in patients, according to a study by Hamilton medical researchers.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.