HPV vaccination after lesion treatment is likely cost-effective

October 11, 2017

(HealthDay)—For HIV-infected men who have sex with men (MSM), adjuvant quadrivalent human papillomavirus vaccination (qHPV) after treatment of high-grade squamous intraepithelial lesions (HSIL) is likely to be cost-effective, according to a study published online Sept. 12 in Vaccine.

Ashish A. Deshmukh, Ph.D., M.P.H., from the University of Florida, Gainesville, and colleagues developed a Markov (state-transition) cohort model to assess the cost-effectiveness of post-HSIL HPV vaccination of HIV-infected MSM (aged 27 and older).

Using the willingness-to-pay threshold of $100,000 per quality-adjusted life-year, the researchers found that treatment plus vaccination was the most cost-effective HSIL management strategy, with an incremental cost-effectiveness ratio of $71,937 per quality-adjusted life-year. The population-level expected value of perfect information for conducting future clinical research evaluating HSIL management approaches was $12 million. The expected value of partial perfect information associated with adjuvant qHPV vaccination efficacy, estimated in terms of hazards of decreasing HSIL recurrence, was $0, suggesting that additional data from a future study evaluating efficacy of adjuvant qHPV vaccination would not change the conclusion that treatment plus vaccination was cost-effective.

"Use of adjuvant qHPV vaccination could be considered as a potential strategy to reduce rising anal cancer burden among these high-risk individuals," conclude the authors.

Several authors disclosed financial ties to the pharmaceutical and medical device industries.

Explore further: How the anal cancer epidemic in gay and bi HIV-positive men can be prevented

More information: Abstract/Full Text (subscription or payment may be required)

Related Stories

How the anal cancer epidemic in gay and bi HIV-positive men can be prevented

September 27, 2017
Almost 620,000 gay and bisexual men in the United States were living with HIV in 2014, and 100,000 of these men were not even aware of their infection. These men are 100 times more likely to have anal cancer than HIV-negative ...

Study outlines recommendations for precancerous treatment of anal lesions

September 27, 2017
Currently, no guidelines exist for screening and treatment of precancerous anal lesions or for anal cancer screening because enough is not known about the effectiveness of treating lesions detected through screening. A new ...

HPV vaccination not associated with increased risk of multiple sclerosis, study shows

January 6, 2015
Although some reports have suggested a link between human papillomavirus (HPV) vaccination and development of multiple sclerosis or other demyelinating diseases (a group of central nervous system disorders), a follow-up of ...

How have HPV vaccines affected cervical cancer screening?

June 7, 2017
A new review looks at cervical cancer screening in the era of HPV vaccination. The review notes that trials have demonstrated the efficacy and safety of vaccines against HPV infection, but the complete effect of HPV vaccination ...

70-gene signature not cost-effective in breast cancer

October 18, 2014
(HealthDay)—For patients with node-negative breast cancer (NNBC), the 70-gene signature is unlikely to be cost-effective for guiding adjuvant chemotherapy decision making, according to a study published online Oct. 6 in ...

Herpes zoster vaccine not cost-effective in adults aged 50 years

September 8, 2015
(HealthDay)—For adults aged 50 years, herpes zoster (HZ) vaccine does not appear to be cost-effective, according to a study published online Sept. 8 in the Annals of Internal Medicine.

Recommended for you

Scientists identify 170 potential lung cancer drug targets using unique cellular library

April 19, 2018
After testing more than 200,000 chemical compounds, UT Southwestern's Simmons Cancer Center researchers have identified 170 chemicals that are potential candidates for development into drug therapies for lung cancer.

Discovery adds to evidence that some children are predisposed to develop leukemia

April 19, 2018
St. Jude Children's Research Hospital researchers have made a discovery that expands the list of genes to include when screening individuals for possible increased susceptibility to childhood leukemia. The finding is reported ...

Mechanism that drives development of liver cancer brought on by non-alcoholic fatty liver disease discovered

April 19, 2018
A team of researchers from several institutions in China has found a mechanism that appears to drive the development of a type of liver cancer not caused by alcohol consumption. In their paper published in the journal Science ...

Protein can slow intestinal tumor growth

April 19, 2018
A new mechanism for regulating stem cells in the intestine of fruit flies has been discovered by researchers at Stockholm University. In addition, it was discovered that a certain protein can slow the growth of tumours in ...

Study predicts 2018 flu vaccine will have 20 percent efficacy

April 19, 2018
A Rice University study predicts that this fall's flu vaccine—a new H3N2 formulation for the first time since 2015—will likely have the same reduced efficacy against the dominant circulating strain of influenza A as the ...

Zika presents hot spots in brains of chicken embryos

April 19, 2018
Zika prefers certain "hot spots" in the brains of chicken embryos, offering insight into how brain development is affected by the virus.


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.