Researchers study mediating role of leptin in bulimia

Researchers study mediating role of leptin in bulimia

(HealthDay)—Leptin appears to mediate the correlation between weight suppression (WS) and duration of illness in bulimia nervosa-syndrome (BN-S), according to a study published online Oct. 16 in the International Journal of Eating Disorders.

Pamela K. Keel, Ph.D., from Florida State University in Tallahassee, and colleagues recruited 53 women (aged 18 to 5 years) from the community who met the criteria for BN-S, including bulimia nervosa (33 women) or purging disorder (20 women), and had a between 18.5 and 26.5 kg/m². Clinical assessments were completed by participants, and they provided blood samples to measure circulating leptin.

The researchers identified significant correlations among greater WS, lower leptin concentration, and longer duration of illness. Mediation analyses using bootstrapping procedures indicated that all paths were significant and that leptin mediated the link between WS and illness duration. There was no support for an alternative model in which longer illness duration contributed to leptin via greater WS.

"Longitudinal research is needed to support temporal associations and explore behavioral mechanisms linking leptin to illness trajectory," the authors write.

More information: Abstract
Full Text (subscription or payment may be required)

Copyright © 2017 HealthDay. All rights reserved.

Citation: Researchers study mediating role of leptin in bulimia (2017, October 26) retrieved 1 February 2023 from
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

Obese inducing brain mechanism


Feedback to editors