Drug combination cost-effective for cesarean prophylaxis

November 14, 2017

(HealthDay)—The addition of azithromycin to cephalosporin for cesarean delivery infection prophylaxis is cost-effective and leads to better maternal outcomes, according to a study published online Nov. 7 in Obstetrics & Gynecology.

Ashley E. Skeith, from Oregon Health and Science University in Portland, and colleagues created a cost-effectiveness model to assess whether adding azithromycin to standard cephalosporin regimens of cesarean prophylaxis would improve maternal outcomes in the current and potential subsequent pregnancies among a theoretical cohort of 700,000 women, the approximate number of nonelective cesarean deliveries that occur annually in the United States during labor or after membrane rupture.

The researchers found that compared with cephalosporin alone for prophylaxis, the model showed 16,100 fewer cases of endometritis, 17 fewer cases of sepsis, eight fewer cases of venous thromboembolism, and one fewer maternal death with azithromycin-cephalosporin. In addition, the drug combination prevented 36 uterine ruptures and four cesarean hysterectomies in a subsequent pregnancy. The addition of azithromycin led to both lower and higher quality-adjusted life-years versus standard cephalosporin prophylaxis. As long as the cost of azithromycin remained below $930 (baseline cost $27), it was cost-effective in sensitivity analysis.

"These findings support the use of prophylactic at the time of cesarean delivery," conclude the authors.

Explore further: Study found adding azithromycin to standard antibiotic reduced infections in C-sections

More information: Abstract/Full Text (subscription or payment may be required)

Related Stories

Study found adding azithromycin to standard antibiotic reduced infections in C-sections

February 1, 2016
In a study to be presented on Feb. 4 in an oral concurrent session, at the Society for Maternal-Fetal Medicine's annual meeting, The Pregnancy Meeting, in Atlanta, researchers with the University of Alabama at Birmingham, ...

Azithromycin given in labor cuts maternal, neonatal infections

January 31, 2017
(HealthDay)—Administration of azithromycin during labor is associated with a reduction in maternal and neonatal clinical infections, according to a study published online Jan. 27 in Pediatrics.

Universal group B streptococci screening not cost-effective

December 13, 2016
(HealthDay)—For women with a singleton pregnancy planning a repeat cesarean delivery, universal group B streptococci (GBS) screening is not cost-effective, according to a study published in the January issue of Obstetrics ...

Antibiotics following C-section among obese women reduces risk of surgical infection

September 19, 2017
Among obese women undergoing cesarean delivery, a postoperative 48-hour course of antibiotics significantly decreased the rate of surgical site infection within 30 days after delivery, according to a study published by JAMA.

Recommendations developed for trial of labor after C-section

October 27, 2017
(HealthDay)—Recommendations have been developed for trial of labor after cesarean delivery (TOLAC) for women who wish to achieve a vaginal birth after cesarean delivery (VBAC), according to a practice bulletin published ...

Administering additional antibiotic prior to C-section reduces infection rates by 50 percent

September 28, 2016
Physicians at the University of Alabama at Birmingham and colleagues have discovered that administering the antibiotic azithromycin alongside the standard recommended antibiotic regimen, cefazolin, reduces infection rates ...

Recommended for you

Why mothers in mainland China, Hong Kong and Taiwan choose cesarean delivery

October 16, 2018
Pregnant women in mainland China, Hong Kong, and Taiwan are more likely to express preference for cesarean section (CS) as their mode of delivery later in pregnancy and postpartum, as compared to early in pregnancy, according ...

Importance of cell cycle and cellular senescence in the placenta discovered

October 15, 2018
Working with researchers from Stanford University and St. Anna Children's Cancer Research, researchers from Jürgen Pollheimer's laboratory at the Medical University of Vienna's Department of Obstetrics and Gynecology have ...

C-section rates have nearly doubled since 2000: study

October 12, 2018
(HealthDay)—The number of women delivering babies via cesarean section has nearly doubled worldwide since 2000, to about 21 percent, new research shows.

Study of nearly 41,000 women who almost died giving birth shows who's most at risk

October 10, 2018
Tens of thousands of American women each year need emergency treatment to save their lives while they deliver their babies, or immediately after. A new study shows how much their risk of a life-threatening birth depends on ...

In childbirth, when to begin pushing does not affect C-section rates

October 9, 2018
More than 3 million women in the United States give birth each year. But obstetricians have differing opinions about when women should begin pushing during labor and whether the timing of pushing increases the likelihood ...

Why single embryo transfer during IVF sometimes results in twins or triplets

October 8, 2018
It has been known for some time that it is better to transfer a single embryo to a woman's womb during assisted reproduction treatment (ART) rather than several embryos in order to avoid a multiple pregnancy and the risks ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.