Magnesium boosts environmental enrichment in Alzheimer's

November 30, 2017

(HealthDay)—The combination of environmental enrichment (EE) and magnesium-L-threonate (MgT) is more effective than either treatment alone for improving cognition and spatial memory in a mouse model of Alzheimer's disease (AD), according to a study published online Nov. 10 in CNS Neuroscience & Therapeutics.

Ying Huang, from Tsinghua University in Beijing, and colleagues treated APP/PS1 mice with EE, MgT, or the combination of EE and MgT (EM), and compared the effect on function.

The researchers found that, compared with either treatment alone, EM was more effective in improving cognition and spatial memory in long-term (12 months; started at age 3 months, before disease manifestation) and short-term (three months; started at age 6 months, after manifestation of disease) treatment. The behavioral improvement corresponded with synaptic contact rescue in the AD mouse brain hippocampal region. EM rescued the activity reduction in two downstream molecules in the N-methyl-D-aspartate receptor (NMDAR) pathway (CaMKII and CREB), but neither single treatment did.

"Environmental enrichment and MgT may synergistically improve recognition and by reducing synaptic loss and restoring the NMDAR signaling pathway in AD mice, which suggests that combination of EE and MgT may be a novel therapeutic strategy for AD," the authors write.

Explore further: RNG105/Caprin1 is essential for long-term memory formation

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

RNG105/Caprin1 is essential for long-term memory formation

November 21, 2017
The research group of Associate Professor Nobuyuki Shiina of the National Institute for Basic Biology have revealed that the function of RNG105 (aka Caprin1) is essential for the formation of long-term memory.

Small-molecule therapeutic boosts spatial memory and motor function in Rett syndrome mice

July 5, 2017
New research into Rett syndrome therapeutics suggests that a small molecule already reported to improve respiratory problems associated with the disease may also improve spatial memory and motor skill defects.

Discovery of new pathway in brain has implications for schizophrenia treatment

May 4, 2017
Neuroscientists at Tufts University School of Medicine have discovered a new signaling pathway that directly connects two major receptors in the brain associated with learning and memory—the N-methyl-D-aspartate receptor ...

Potential Alzheimer's medication shows promise in mouse model of neurodegenerative disease

December 19, 2016
Memory loss and other cognitive symptoms of Alzheimer's disease are attributed, in part, to the degeneration of acetylcholine-producing neurons. Acetylcholinesterase inhibitors are a common treatment for patients with Alzheimer's; ...

Research on advanced Alzheimer's disease investigates novel ways to restore cognitive function

June 27, 2017
While most research on Alzheimer's disease (AD) has focused on early diagnosis and treatment, University at Buffalo scientists are studying genetic and epigenetic factors with the ultimate goal of restoring function to patients ...

Recommended for you

Being hungry shuts off perception of chronic pain

March 22, 2018
Pain can be valuable. Without it, we might let our hand linger on a hot stove, for example. But longer-lasting pain, such as the inflammatory pain that can arise after injury, can be debilitating and costly, preventing us ...

From signal propagation to consciousness: New findings point to a potential connection

March 22, 2018
Researchers at New York University have discovered a novel mechanism through which information can be effectively transmitted across many areas in the brain—a finding that offers a potentially new way of understanding how ...

Using simplicity for complexity—new research sheds light on the perception of motion

March 22, 2018
A team of biologists has deciphered how neurons used in the perception of motion form in the brain of a fly —a finding that illustrates how complex neuronal circuits are constructed from simple developmental rules.

Focus on early stage of illness may be key to treating ALS, study suggests

March 22, 2018
A new kind of genetically engineered mouse and an innovation in how to monitor those mice during research have shed new light on the early development of an inherited form of amyotrophic lateral sclerosis (ALS).

Flow of spinal fluid disrupted in inherited developmental disorder

March 22, 2018
Scientists have pinpointed the mechanism behind hydrocephalus, an accumulation of cerebrospinal fluid around the brain, in an inherited developmental disorder called Noonan syndrome.

Stiffness of connection influences exchange of physical cues during coordinated movements

March 22, 2018
When two people coordinate their movements, such as by holding hands or moving furniture, they exchange physical cues through the objects that connect them. New research published in PLOS Computational Biology suggests that ...


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.