In vitro fertilization linked with increased risk of congenital heart defects

November 22, 2017, Wiley

A new analysis of published studies found a 45% increased risk of congenital heart defects in newborns when women become pregnant via in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) than through spontaneous conception.

The Ultrasound in Obstetrics and Gynecology analysis included 8 studies with 25,856 children obtained from IVF techniques and 287,995 children spontaneously conceived and a total of 2289 .

Congenital heart defects were found in 1.30% and 0.68% in the IVF/ICSI and spontaneous conception groups, respectively.

"We believe that IVF/ICSI pregnancies present an of CHDs as a consequence of early placental dysfunction; however this hypothesis should be demonstrated in future studies. We recommend fetal echocardiography in all pregnancies from IVF/ICSI," said lead author Dr. Paolo Cavoretto, of the IRCCS San Raffaele Hospital, in Milan, Italy.

Explore further: In vitro fertilization linked with increased risk of spontaneous preterm birth

More information: Veronica Giorgione et al, Congenital heart defects in IVF/ICSI pregnancy: a systematic review and meta-analysis, Ultrasound in Obstetrics & Gynecology (2017). DOI: 10.1002/uog.18932

Related Stories

In vitro fertilization linked with increased risk of spontaneous preterm birth

November 8, 2017
A new analysis of published studies found an approximate 80% increased risk of spontaneous preterm birth (both before 37 and 34 weeks) when women become pregnant via in vitro fertilization (IVF) than through spontaneous conception.

Could assisted reproduction reduce birth defects for older women?

October 17, 2016
Babies born to women aged 40 and over from assisted reproduction have fewer birth defects compared with those from women who conceive naturally at the same age, according to new research from the University of Adelaide.

Study examines if timing of IVF to avoid weekend procedures affects pregnancy success

October 25, 2017
It's unclear whether there is a need to retrieve a woman's eggs on weekends, in connection with in vitro fertilization/intracytoplasmatic sperm injection (IVF/ICSI) treatment in couples wishing to conceive. In a recent Acta ...

Males conceived via fertility treatment may have weakened sperm: study

October 7, 2016
(HealthDay)—Males who were conceived using an infertility treatment where sperm is injected into an egg may themselves have lower sperm quantity and quality than those conceived naturally, Belgian researchers report.

Higher risk of birth defects from assisted reproduction

May 6, 2012
A University of Adelaide study has identified the risk of major birth defects associated with different types of assisted reproductive technology.

Use of IVF procedure for male infertility has doubled; not linked with improved outcomes

January 20, 2015
The use of an assisted reproduction technique known as intracytoplasmic sperm injection (ICSI) doubled between 1996 and 2012, although compared with conventional in vitro fertilization (IVF), use of ICSI was not associated ...

Recommended for you

Vaginal estrogen tablets, moisturizers and placebo gel all can improve vaginal discomfort

March 19, 2018
A clinical trial comparing two treatments for postmenopausal vaginal discomfort - low-dose vaginal estrogen and a vaginal moisturizer - to placebo treatments found that both produced symptom improvements similar to those ...

Discovery promises improved diagnosis and understanding of endometriosis

March 19, 2018
Feinstein Institute for Medical Research scientists announced an experimental, rapid and non-invasive way to diagnose endometriosis, which may lead to earlier and more effective treatments for this disorder that affects approximately ...

Frozen embryos more successful for conceiving during IVF

March 19, 2018
A new study carried out by a research team at The University of Western Australia and Fertility Specialists of Western Australia has found that women undergoing IVF who have had embryos fail to implant have more success using ...

Alomst 70 percent of 103 genes linked to prenatal death affect the placenta

March 14, 2018
The role of the placenta in healthy fetal development is being seriously under-appreciated according to a new paper published today (14th March). The study was part of the Wellcome Trust-funded "Deciphering the Mechanisms ...

New research shows why babies need to move in the womb

March 12, 2018
Scientists have just discovered why babies need to move in the womb to develop strong bones and joints. It turns out there are some key molecular interactions that are stimulated by movement and which guide the cells and ...

Labour–inducing drugs put to the test

February 27, 2018
Researchers comparing the use of two drugs for pregnant women who do not go into labour shortly after their waters break have found both are reasonable options.


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.