Lower microbial diversity in the gut in anorexia nervosa

December 4, 2017

(HealthDay)—Females with anorexia nervosa (AN) have lower gut microbial diversity, according to a study published online Nov. 13 in the International Journal of Eating Disorders.

Sabrina Mörkl, M.D., from the University of Graz in Austria, and colleagues included 106 female patients in a cross-sectional study: 18 with AN, 20 athletes, 26 normal-weight, 22 overweight, and 20 . DNA was extracted from stool samples and 16S rRNA gene analysis was performed.

The researchers found that patients with AN and obese participants had lower alpha compared with other groups, while the highest alpha diversity was seen for athletes. Significant associations were identified for several categories with community structure: body fat parameters, serum lipids, C-reactive protein, depression scales, and smoking. In comparative analysis, Coriobacteriaceae was the only enriched phylotype in AN versus other entities.

"This study provides further evidence of intestinal dysbiosis in AN and sheds light on characteristics of the in different body mass index and physical activity groups," the authors write. "These insights point to new modulation possibilities of the which could improve the standard therapy of AN."

Explore further: ACG: fecal transplant safe in primary sclerosing cholangitis

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

ACG: fecal transplant safe in primary sclerosing cholangitis

October 16, 2017
(HealthDay)—Fecal microbiota transplantation (FMT) from a rationally selected donor seems safe and effective for patients with primary sclerosing cholangitis (PSC), according to a study presented at the World Congress of ...

Both obese and anorexic women have low levels of 'feel good' neurosteroid

November 10, 2017
Women at opposite extremes of the weight spectrum have low levels of the neuroactive steroid allopregnanolone, according to new research published in the journal Neuropsychopharmacology.

Gut microbiome diversity lower in chronic pelvic pain syndrome

July 25, 2016
(HealthDay)—Gut microbiome diversity is significantly lower in patients with chronic pelvic pain syndrome, with wider clustering, according to a study published in the August issue of The Journal of Urology.

Probiotics linked to weight loss in obese, overweight

October 29, 2017
(HealthDay)—Short-term probiotics are associated with reductions in body weight, body mass index (BMI), and fat percentage in overweight or obese subjects, according to research published online Oct. 18 in Obesity Reviews.

Microbiome linked to infectious complications in AML

May 9, 2016
(HealthDay)—For patients with acute myelogenous leukemia (AML) undergoing induction chemotherapy (IC), gastrointestinal microbiome composition is associated with infectious complications, according to a study published ...

Researchers study mediating role of leptin in bulimia

October 26, 2017
(HealthDay)—Leptin appears to mediate the correlation between weight suppression (WS) and duration of illness in bulimia nervosa-syndrome (BN-S), according to a study published online Oct. 16 in the International Journal ...

Recommended for you

Obesity plagues rural America

June 19, 2018
(HealthDay)—Country folk are being hit harder by the U.S. obesity epidemic than city dwellers, two new government studies show.

Binging, purging and fasting more common in overweight, obese young adults

June 12, 2018
Young adults who are overweight or obese are twice as likely as their leaner peers to binge and purge, use laxatives or diuretics, or force themselves to vomit as a means of controlling their weight, according to a new study ...

Study offers new hope for the fight against genetically determined obesity

June 3, 2018
Around 2 to 6 percent of all people with obesity develop the condition in early childhood. Obesity-causal mutations in one of the 'appetite genes' gives them a strong genetic predisposition for developing obesity, also called ...

Abnormal lipid metabolism in fat cells predicts future weight gain and diabetes in women

May 31, 2018
The inefficient breakdown of fats predicts later weight gain and metabolic complications such as type 2 diabetes in women, researchers report May 31 in the journal Cell Metabolism. Low levels of hormone-stimulated lipolysis—a ...

Antidepressant use may contribute to long-term population weight gain

May 24, 2018
Researchers at King's College London have found that patients prescribed any of the 12 most commonly used antidepressants were 21% more likely to experience an episode of gain weight than those not taking the drugs, (after ...

Bid to beat obesity focuses on fat that keeps us warm

May 24, 2018
A new technique to study fat stores in the body could aid efforts to find treatments to tackle obesity.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.