Storage in dose administration aids doesn't affect warfarin

December 4, 2017

(HealthDay)—The chemical stability of warfarin sodium tablets is not affected by repackaging into dose administration aids (DAAs), according to a study published online Nov. 16 in the Journal of Pharmacy Practice and Research.

Caynan Mendes Rugno, B.Pharm., from RMIT University in Bundoora, Australia, and colleagues examined the of sodium tablets stored in DAAs and original packaging over an eight-week period. Tablets were removed from the original packaging and repackaged into DAAs; DAAs and original packages were stored at controlled room temperature (25 degrees Celsius; 60 percent relative humidity [RH]), accelerated (40 degrees Celsius/75 percent RH), and uncontrolled room temperature conditions (19 to 21 degrees Celsius/38 to 50 percent RH). A validated high-performance liquid chromatography method was used to assess the chemical stability.

The researchers found that at eight weeks there was no significant change in warfarin content. When stored at accelerated and controlled room temperature conditions there was a significant increase in hardness. At eight weeks, hardness of tablets stored in original packaging was comparable to that of those stored in DAAs. Compared with baseline, there was a significant difference in the dissolution profile of tablets stored in original containers at accelerated conditions for eight weeks.

"Repackaging of warfarin sodium tablets into DAAs does not affect the ," the authors write. "However, tablets should be stored in a cool, dry place to minimize the effects on physical properties."

Explore further: Bevacizumab safe, stable for multiple dosing from single vial

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Bevacizumab safe, stable for multiple dosing from single vial

July 24, 2015
(HealthDay)—Bevacizumab is safe and stable when stored at 4 degrees Celsius, even with multiple dosing from a single vial, according to a study published in the July issue of Clinical & Experimental Ophthalmology.

More diabetes-associated, non-associated autoantibodies in T1D

September 6, 2016
(HealthDay)—Patients with type 1 diabetes have more diabetes-associated autoantibodies (DAAs) and non-DAAs than patients with type 2 diabetes, according to a study published online Aug. 29 in Diabetes Care.

One-third of patients don't retain important warfarin info

August 15, 2016
(HealthDay)—Just over two-thirds of patients retain an "acceptable" amount of key information following warfarin counseling, according to a small study published online Aug. 6 in the Journal of Pharmacy Practice and Research.

Stability of fragrance patch test preparations examined

July 26, 2012
(HealthDay) -- Concentrations of several fragrance allergens applied to test chambers well in advance of patient testing may be reduced by 20 percent or more within hours when stored at room temperature, according to a study ...

Warfarin, rivaroxaban similarly safe, effective

September 12, 2017
(HealthDay)—For cases of mild atrial fibrillation (AF)-related acute ischemic stroke, rivaroxaban and warfarin are similarly safe and effective at preventing recurrent stroke, according to a study published online Sept. ...

HBV reactivation is concern with DAA Tx in HBV-HCV coinfection

April 25, 2017
(HealthDay)—Hepatitis B virus (HBV) reactivation (HBV-R) is a safety concern for patients with HBV and hepatitis C virus (HCV) coinfection receiving direct-acting antiviral agents (DAAs), according to a study published ...

Recommended for you

Height may be risk factor for varicose veins, study finds

September 24, 2018
The taller you are, the more likely you are to develop varicose veins, according to a study led by Stanford University School of Medicine researchers that examined the genes of more than 400,000 people in search of clues ...

Prosthetic valve mismatches common in transcatheter valve replacement, ups risk of death

September 24, 2018
In the largest multi-institutional study to date, led by researchers from Penn Medicine, the team found that among patients who underwent a transcatheter aortic valve replacement (TAVR), a high number experienced severe and ...

Study reveals a promising alternative to corticosteroids in acute renal failure treatment

September 21, 2018
A protein produced by the human body appears to be a promising new drug candidate to treat conditions that lead to acute renal failure. This is shown by a study conducted at São Paulo State University (UNESP) in São José ...

Can a common heart condition cause sudden death?

September 20, 2018
About one person out of 500 has a heart condition known as hypertrophic cardiomyopathy (HCM). This condition causes thickening of the heart muscle and results in defects in the heart's electrical system. Under conditions ...

New drugs could reduce risk of heart disease when added to statins

September 20, 2018
New drugs that lower levels of triglycerides (a type of fat) in blood could further reduce the risk of heart attack when added to statins. These new drugs, which are in various stages of development, could also reduce blood ...

Mediterranean-style diet may lower women's stroke risk

September 20, 2018
Following a Mediterranean-style diet may reduce stroke risk in women over 40 but not in men—according to new research led by the University of East Anglia.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.