HDL and kidney injury after surgery

January 18, 2018 by Jenelle Grewell, Vanderbilt University

Higher concentrations of high-density lipoproteins—HDL, the "good" cholesterol—may be protective against acute kidney injury (AKI) after cardiac surgery, Vanderbilt researchers have discovered. AKI affects up to 30 percent of patients after cardiac surgery.

Loren Smith, MD, Ph.D., and colleagues evaluated 391 patients participating in a of a statin drug to reduce AKI after . They found that a higher preoperative HDL concentration was associated with decreased postoperative creatinine change (a measure of kidney function). The association was strongest in patients who were long-term statin users and was further enhanced in patients who had perioperative statin treatment.

The findings, reported in the Journal of the American Heart Association, identify HDL as a potentially modifiable risk factor for postoperative AKI. The researchers stress, however, that perioperative statins have not prevented AKI in three randomized clinical trials and that other agents which improve HDL function are needed.

Explore further: High-dose statin before, after cardiac surgery does not reduce risk of kidney injury

More information: Loren E. Smith et al. High‐Density Lipoprotein Cholesterol Concentration and Acute Kidney Injury After Cardiac Surgery, Journal of the American Heart Association (2017). DOI: 10.1161/JAHA.117.006975

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