Ertugliflozin tied to improved glycemic control in T2DM

February 20, 2018

(HealthDay)—For adults with inadequately controlled type 2 diabetes, ertugliflozin treatment is associated with improved glycemic control over 52 weeks, according to a study published online Feb. 8 in Diabetes, Obesity and Metabolism.

Ronnie Aronson, M.D., from LMC Diabetes & Endocrinology in Ontario, and colleagues conducted a phase III randomized trial to examine the efficacy and safety of ertugliflozin monotherapy in adults with inadequately controlled type 2 despite diet and exercise. The study comprised a 26-week placebo-controlled period where 461 participants received placebo or ertugliflozin (5 or 15 mg/day) and a second 26-week period in which in the had blinded metformin added.

The researchers found that the mean change in glycated hemoglobin (HbA1c) from baseline to week 52 was −0.9 and −1 percent in the ertugliflozin 5- and 15-mg groups, respectively; the proportion of patients with HbA1c <7 percent was 25.6 and 28.5 percent, respectively, at week 52. Ertugliflozin was correlated with a reduction in fasting plasma glucose, body weight, and systolic blood pressure. In females, the incidence of genital mycotic infections (GMIs) was significantly higher in both the 5- and 15-mg ertugliflozin groups versus placebo/metformin (26.9 and 29 versus 9.9 percent); males had significantly higher GMI incidence in the 15-mg group (7.8 versus 1.2 percent).

"Ertugliflozin treatment over 52 weeks improved and reduced body weight and systolic blood pressure but increased GMIs," the authors write.

Several authors disclosed financial ties to pharmaceutical companies, including Pfizer and Merck & Co., which funded the study.

Explore further: Addition of DPP4i to AGI reduces HbA1c in T2DM

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Addition of DPP4i to AGI reduces HbA1c in T2DM

October 5, 2017
(HealthDay)—For patients with type 2 diabetes mellitus (T2DM), inadequately controlled with alpha-glucosidase inhibitors (AGIs), the addition of a dipeptidyl peptidase-4 (DPP4) inhibitor (DPP4i) is associated with a greater ...

Ranolazine added to glimepiride cuts HbA1c in T2DM

January 18, 2016
(HealthDay)—For patients with type 2 diabetes on background glimepiride therapy, but not metformin, addition of ranolazine is associated with a significant reduction in hemoglobin A1c (HbA1c), according to research published ...

Diacerein reduces mean hemoglobin A1c levels in T2DM

August 25, 2017
(HealthDay)—An immune-modulator anti-inflammatory drug, diacerein, reduces the mean hemoglobin A1c (HbA1c) levels in patients with type 2 diabetes, according to a study published online Aug. 17 in Diabetes Care.

Imeglimin beneficial as add-on to metformin in T2DM

December 14, 2012
(HealthDay)—For patients with type 2 diabetes inadequately controlled by metformin alone, addition of the new oral anti-diabetes agent imeglimin improves glycemic control with good tolerability and safety, according to ...

Liraglutide tops lixisenatide as add-on to metformin in T2DM

June 28, 2016
(HealthDay)—For patients with type 2 diabetes taking metformin, add-on liraglutide is more effective than lixisenatide for improving glycemic control, according to a study published online June 16 in Diabetes Care.

Glucagon receptor antagonist ups blood pressure in T2DM

February 23, 2017
(HealthDay)—For patients with type 2 diabetes, once-daily treatment with the glucagon receptor antagonist LY2409021 is associated with increases in ambulatory blood pressure (BP), according to a study published online Feb. ...

Recommended for you

Researchers have found that incidence of heart failure was around two-fold higher in people with diabetes

December 11, 2018
Researchers have found that incidence of heart failure was around two-fold higher in people with diabetes.

Millions of low-risk people with diabetes may be testing their blood sugar too often

December 10, 2018
For people with Type 2 diabetes, the task of testing their blood sugar with a fingertip prick and a drop of blood on a special strip of paper becomes part of everyday life.

Very low calorie diets trialled by NHS to tackle diabetes

December 7, 2018
Hundreds of thousands of people will receive NHS help to battle obesity and type 2 diabetes under radical action set out by Simon Stevens, Chief Executive of NHS England.

New therapeutic avenue for type 2 diabetes

December 6, 2018
Restoring the action of insulin is one of the keys to fighting type 2 diabetes. Researchers from Inserm led by Dominique Langin at the Institute of Cardiovascular and Metabolic Diseases (Inserm/Université de Toulouse) are ...

Subtype of immune B cells can delay type 1 diabetes onset in mice

December 6, 2018
A team of researchers at Baylor College of Medicine and the University of Michigan Medical School reports today in the JCI Insight that a subset of immune B cells, known as CD19+IgM+ B cells, can delay the onset of type 1 ...

Is the pancreas regeneration debate settled? An original theory renewed

December 5, 2018
A contentious debate among diabetes researchers has surrounded the regeneration of pancreatic insulin-producing cells: not if these cells regenerate, but rather how.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.