IL-6 levels predict response to ECT in depressive disorder

March 14, 2018

(HealthDay)—For patients with major depressive disorder, interleukin-6 (IL-6) may predict benefit from electroconvulsive therapy (ECT), according to a study published recently in the Journal of Clinical Psychiatry.

Jennifer L. Kruse, M.D., from the University of California at Los Angeles, and colleagues examined whether markers of inflammation predicted response to ECT in patients with treatment-resistant depression. Levels of C-reactive protein (CRP), IL-6, IL-8, and α, and severity of (Montgomery-Asberg Depression Rating Scale [MADRS]) were assessed before ECT treatment, after the second ECT session, and at completion of the index treatment series in 29 patients.

The researchers found that there was a correlation for higher IL-6 levels at baseline, but not other inflammatory markers or clinical variables, with lower end-of-treatment MADRS score (P = 0.01). IL-6 remained a significant predictor of end-of treatment MADRS for women (P = 0.02), but not men (P = 0.1), when stratified by sex; CRP was a significant predictor for women (P = 0.04), but not men (P = 0.66). There were increases in CRP and IL-6 from baseline to the second ECT session (P < 0.01); levels returned to baseline at the end of treatment. These changes were not associated with MADRS score over the course of ECT.

"Levels of IL-6 prior to ECT treatment may be useful in identifying those depressed patients most likely to benefit from ECT treatment," the authors write.

Explore further: Level of inflammation could help predict effectiveness of electroconvulsive therapy for major depression

More information: Abstract/Full Text (subscription or payment may be required)

Related Stories

Level of inflammation could help predict effectiveness of electroconvulsive therapy for major depression

March 6, 2018
People with major depression that has not been well controlled by medications and who have a biomarker in their blood indicating a higher level of inflammation may benefit more than people with less inflammation from electroconvulsive ...

Could depression be treated with Botox?

April 1, 2014
In the largest randomized, double-blind, placebo controlled study to date on the effect of OnabotulinumtoxinA (as known as Botox) on depression, researchers found that more than half of subjects suffering from moderate to ...

Esketamine safe, effective for treatment-resistant depression

January 4, 2018
(HealthDay)—Esketamine seems to be efficacious and safe for patients with treatment-resistant depression (TRD), according to a study published online Dec. 27 in JAMA Psychiatry.

Network density not linked to response in teen depression

December 4, 2017
(HealthDay)—Adolescents with depression who are poor responders to treatment do not have more densely connected networks, according to a research letter published online Nov. 29 in JAMA Psychiatry.

Predictors of infliximab response in ulcerative colitis identified

January 3, 2018
(HealthDay)—For patients with acute severe ulcerative colitis (ASUC), the baseline Mayo Endoscopic Score and the C-reactive protein (CRP)/albumin ratio predict treatment response to infliximab, according to research published ...

Memantine plus sertraline effective for major depressive disorder

November 7, 2016
(HealthDay)—The combination of memantine plus sertraline is efficacious for major depressive disorder, according to a study published online Nov. 3 in the Journal of Clinical Pharmacy and Therapeutics.

Recommended for you

We start caring about our reputations as early as kindergarten

March 20, 2018
Kindergarteners don't use social media, but they do care about their public image. Research suggests that by the time kids go to elementary school, they're thinking critically about their reputation. In a Review published ...

We can read each other's emotions from surprisingly tiny changes in facial color, study finds

March 19, 2018
Our faces broadcast our feelings in living color—even when we don't move a muscle.

Social media use at age 10 could reduce wellbeing of adolescent girls

March 19, 2018
Social media use may have different effects on wellbeing in adolescent boys and girls, according to research published in the open access journal BMC Public Health.

Study with infants suggests language not necessary for reasoning ability

March 16, 2018
A team of researchers from Spain, Hungary and Poland has found via a study with infants that language may not be a necessity for the ability to reason. In their paper published in the journal Science, the group describes ...

Hep C compounds alcoholism's effect on brain volume

March 16, 2018
(HealthDay)—Alcohol dependence has deleterious effects on frontal cortical volumes that are compounded by hepatitis C virus (HCV) infection and drug dependence, according to a study published online March 14 in JAMA Psychiatry.

Study casts doubt on ketamine nasal sprays for depression

March 16, 2018
Researchers from the Black Dog Institute and UNSW Sydney have questioned the efficacy and safety of intranasal ketamine for depression, with their pilot trial stopped early due to poor side effects in patients.


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.