Malaria control strategies reduce the caseload but bring new challenges

March 6, 2018 by Andrew Githeko And Ednah Ototo, The Conversation
Credit: CC0 Public Domain

Kenya's two major malaria prevention strategies – indoor residual spraying of homes in high transmission areas and the issuing of insecticide treated nets – have led to a significant reduction in malaria transmission.

The two methods were introduced in the country's western highlands, traditionally considered a high transmission area, about a decade ago and have resulted in the disease's caseload decreasing by about 80%.

But the drop in cases has brought a new challenge: have begun losing their immunity to the disease. The consequence is that they are prone to contracting more complicated forms of the malaria that could result in death.

There are two types of immunity that people are able to develop naturally: clinical immunity and parasitological immunity.

People living in high transmission areas develop clinical immunity naturally after being exposed to the virus and receiving successful treatment. Their bodies are able to resist infection.

They are also able to develop parasitological immunity. After being bitten by many infected mosquitoes over a long period, their bodies are able to withstand higher numbers of parasites in their .

When people don't have parasitological immunity, they face the risk of becoming severely ill when the number of parasites in the blood increases. This can take the form of severe anaemia, cerebral malaria and eventually death. Children are particularly susceptible.

In our study we focused on parasitological immunity in children. We wanted to understand how malaria prevention interventions such as bed nets and indoor spraying were preventing people from developing parasitological immunity.

We found that children who were less exposed to malaria as they grew up had lower levels of parasitological immunity. This exposed them to developing more severe strains of malaria.

Our findings should be taken on board as part of Kenya's broader malaria prevention strategies. The government needs to maintain strong monitoring and surveillance networks to ensure that existing interventions are still sufficient. And it needs to work out new interventions to deal with the consequences of its interventions.

Our study

There is no functional test to measure the level of immune protection a person has developed. Some people have higher levels of immunity with fewer parasites in their blood.

Even though it's not possible to pin down how individuals will react to malaria it is nevertheless possible to work out a person's parasitological immunity.

Parasitological immunity is established by measuring the proportion of red blood cells that are infected in the body. Most people who get malaria have less than 1% of their red blood cells infected with the parasite, which rapidly multiplies. A person with 5% of their infected is considered severely toxic.

We compared two sets of children, looking at the relationship between age and parasite density. We did two sets of surveys nine years apart. The first was done between June 2002 and December 2003 and the second between January 2012 and February 2015. School children between the ages of six and 13 were tested for malarial parasites in both periods.

When we did the first set of tests, malaria prevention tools had not yet been introduced in the highlands. The second set of children were exposed to the prevention tools.

We recorded the blood parasite densities – and thus infections trends – in each of the age groups. By doing this we were able to compare how the parasite density had changed between those who had grown up with bednets and indoor spraying or taken anti-malarial drugs, and those who hadn't.

We found that people who had not experienced early interventions had high levels of immunity.

A new gap

But there's a knock-on effect that complicates the scenario even further. People who hadn't taken anti-malarial medicines or used treated bed nets were more likely to infect mosquitoes because they continued to carry parasites in their blood.

This makes the rest of the population more susceptible to infections, with implications for the country's broader strategy.

The risk of increased infection brings added complexity to government's efforts. The only way to meet the challenge is to ensure that there are sufficient monitoring and surveillance strategies.

Another reason monitoring and evaluation matters is because mosquitoes are able to evolve and develop resistance to insecticides. In addition malaria can become resistant to anti-malarial drugs.

Mosquitoes have also been shown to change their behaviour, such as avoiding contact with insecticide treated surfaces. Where are used they have been shown to change from night time feeding to daytime or evenings before people go to sleep.

If the government does not pick up these new trends early, as well as new and more severe infections, it will lose the gains it's made against fighting .

Explore further: Human antibodies undermine parasite sex

Related Stories

Human antibodies undermine parasite sex

February 8, 2018
Some people develop an immune response following a malaria infection that stops them from infecting other mosquitoes. The antibodies that these people produce are ingested by the mosquito and destroy the malaria parasite ...

Cross-species malaria immunity induced by chemically attenuated parasites

July 1, 2013
Malaria, a mosquito-born infectious disease, kills over 600,000 people every year. Research has focused on the development of a vaccine to prevent the disease; however, many malaria vaccines targeting parasite antigens have ...

Malaria severity not determined solely by parasite levels in blood

May 7, 2014
Although malaria kills some 600,000 African children each year, most cases of the mosquito-borne parasitic disease in children are mild. Repeated infection does generate some immunity, and episodes of severe malaria are unusual ...

Insecticide-treated nets may still prevent malaria despite mosquito resistance

February 26, 2016
Insecticide-treated nets may still help prevent malaria despite mosquitoes developing resistance, according to a new study published in Parasites & Vectors.

Discovery of key molecules involved in severe malaria – new target for malaria vaccine

December 4, 2017
Malaria is one of three major infectious diseases affecting approximately 300 million people every year, accounting for about 500,000 deaths, but effective vaccine development has not been successful. Among malaria parasites ...

Malaria parasite may trigger human odor to lure mosquitoes

February 9, 2017
Scientists may have figured out part of the reason why mosquitoes are drawn to people infected with malaria.

Recommended for you

Researchers discover influenza virus doesn't replicate equally in all cells

September 19, 2018
The seasonal flu is caused by different subtypes of Influenza A virus and typically leads to the death of half a million people each year. In order to better understand this virus and how it spreads, University of Minnesota ...

Drugs that stop mosquitoes catching malaria could help eradicate the disease

September 18, 2018
Researchers have identified compounds that could prevent malaria parasites from being able to infect mosquitoes, halting the spread of disease.

Vaccine opt-outs dropped slightly when California added more hurdles

September 18, 2018
In response to spiking rates of parents opting their children out of vaccinations that are required to enroll in school—and just before a huge outbreak of measles at Disneyland in 2014—California passed AB-2109. The law ...

New evidence of a preventative therapy for gout

September 17, 2018
Among patients with cardiovascular disease, it's a common complaint: a sudden, piercing pain, stiffness or tenderness in a joint that lasts for days at a time with all signs pointing to a gout attack. Gout and cardiovascular ...

"Atypical" virus discovered to be driver of certain kidney diseases

September 14, 2018
An international research team led by Wolfgang Weninger has discovered a previously unknown virus that acts as a "driver" for certain kidney diseases (interstitial nephropathy). This "atypical" virus, which the scientists ...

Flu shot rates in clinics drop as day progresses, but nudges help give them a boost

September 14, 2018
Primary care clinics experienced a significant decline in influenza vaccinations as the day progressed, researchers from Penn Medicine report in a new study published in JAMA Open Network. However, "nudging" clinical staff ...


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.