Precision oncology in advanced cancer patients improves overall survival

Precision oncology in advanced cancer patients improves overall survival
Costs per patient among the health system health plan members in the last 3 months of life, by site of care. Standard Tx: Select Health members with relevant cancer diagnoses who did not receive targeted therapy as part of their treatment course (N = 1,721). Targeted Tx: Select Health members with relevant cancer diagnoses who received targeted therapy as part of their treatment course (N = 93). 'All other' includes home health, hospice, and all other sites of care. Only health plan members with relevant cancer Dx and for whom date of death was recorded are included in analysis. Credit: Lincoln D. Nadauld

The use of advanced molecular diagnostic technologies, such as Next-Generation Sequencing based gene panel testing, to select targeted therapies in advanced cancer patients is known as precision oncology.

In order to evaluate the impact of precision cancer medicine beyond the PFS window and to determine the degree to which any survival or cost advantages persisted, they conducted a follow up analysis on the subset of 44 patients from the original study to measure overall survival, average total healthcare , and resource utilization over the entire observation period, from the start of the study through either death or last observed encounter.

Building on a matched cohort study of 44 patients with metastatic cancer who received all of their care within a single institution, researchers from the Precision Genomics & Navican Genomics at Intermountain Healthcare and the Division of Oncology, Department of Medicine, at Stanford University School of Medicine evaluated the overall survival and healthcare costs for each patient.

A separate analysis of 1,814 patients with late-stage cancer diagnoses found that those who received a targeted treatment had 6.9% lower costs in the last 3 months of life compared with those who did not.

"In particular, inpatient costs were 47.4% lower for targeted patients during that period, which offset higher outpatient, office, and prescription drug costs."

Dates of death were available for all 22 patients in the control arm, and for 18 patients in the targeted treatment arm. Patients in the precision medicine group received targeted therapy based on genomic profiling and a molecular tumor board interpretation, while patients in the received standard molecular testing indicated for their disease type.

Within the control group, one patients post-PFS survival period had a significant impact on the overall median; this patient survived 187 weeks after the PFS period, more than 400% greater than the next highest value within the control group.

Average costs per week over the entire period were significantly lower for the targeted treatment group compared with the control group.

Moreover, resource use intensity for patients in the targeted group was lower in both higher-cost, acute settings such as inpatient and ER as well in the lower acuity outpatient setting, compared to .


Explore further

Routine genomic testing is feasible, but only a subset of patients benefit

More information: Derrick S. Haslem et al. Precision oncology in advanced cancer patients improves overall survival with lower weekly healthcare costs, Oncotarget (2018). DOI: 10.18632/oncotarget.24384
Journal information: Oncotarget

Provided by Rapamycin Press
Citation: Precision oncology in advanced cancer patients improves overall survival (2018, March 12) retrieved 26 September 2020 from https://medicalxpress.com/news/2018-03-precision-oncology-advanced-cancer-patients.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
1 shares

Feedback to editors

User comments