Rational protein engineering can improve effectiveness of mRNA therapies

Rational protein engineering can improve effectiveness of mRNA therapies
Credit: Mary Ann Liebert, Inc., publishers

mRNA drugs offer a promising new approach to deliver therapeutic replacement proteins, and novel strategies designed to engineer more stable and active proteins are further enhancing the potential of mRNA therapies. Specific examples of sequence engineering that led to improved expression, duration, and enzymatic activity of target proteins are reported in a study published in Nucleic Acid Therapeutics.

The article entitled "Leveraging Rational Protein Engineering to Improve mRNA Therapeutics" is coauthored by Romesh Subramanian, Alexion Pharmaceuticals, Cambridge, MA and colleagues from Alexion, New Haven, CT. The researchers described the methods they used to engineer specific protein sequences and demonstrated the positive effects this had on protein expression in mice. Sequence engineering was also able to improve the thermostability and activity of the therapeutic enzymes.

"Developing protein variants with improved stability and activity should reduce necessary dosing frequency, and hence improve patient compliance" says Executive Editor Graham C. Parker, PhD, The Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Children's Hospital of Michigan, Detroit, MI.


Explore further

New options for targeting gene mutation in FA described in nucleic acid therapeutics

More information: Jeremiah D. Farelli et al, Leveraging Rational Protein Engineering to Improve mRNA Therapeutics, Nucleic Acid Therapeutics (2018). DOI: 10.1089/nat.2017.0697
Citation: Rational protein engineering can improve effectiveness of mRNA therapies (2018, March 30) retrieved 13 November 2019 from https://medicalxpress.com/news/2018-03-rational-protein-effectiveness-mrna-therapies.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
5 shares

Feedback to editors

User comments