Erectile dysfunction drugs may help treat many other conditions

A new British Journal of Pharmacology review examines how phosphodiesterase-5 (PDE5) inhibitors, which were originally approved to treat erectile dysfunction, are finding clinical uses for a wide variety of conditions.

PDE5 inhibitors cause blood vessel dilation by targeting a particular cellular pathway that is involved in many normal physiological functions and in the pathophysiology of a wide range of diseases.

PDE5 inhibitors likely have effects on many organs and functions, and they have been approved to treat symptoms and . They are also being used off-label to treat conditions including diabetes and cancer.


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More information: K-E Andersson, PDE5 Inhibitors - Pharmacology and Clinical Applications 20 Years After Sildenafil Discovery, British Journal of Pharmacology (2018). DOI: 10.1111/bph.14205
Provided by Wiley
Citation: Erectile dysfunction drugs may help treat many other conditions (2018, April 19) retrieved 20 February 2019 from https://medicalxpress.com/news/2018-04-erectile-dysfunction-drugs-conditions.html
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