High FGF-23 linked to recurrent cardiac events after ACS

April 23, 2018

(HealthDay)—Elevated fibroblast growth factor 23 (FGF-23) is associated with increased risk of recurrent major cardiovascular (CV) events in patients after an acute coronary syndrome (ACS), according to a study published online April 18 in JAMA Cardiology.

Brian A. Bergmark, M.D., from Brigham and Women's Hospital in Boston, and colleagues measured C-terminal FGF-23 in plasma samples for 4,947 patients within 30 days of ACS and with one additional CV risk factor in the Stabilization of Plaques Using Darapladib-Thrombolysis in Myocardial Infarction 52 trial.

The researchers found that FGF-23 concentration in the top quartile was independently linked to an increased risk of CV death or heart failure hospitalization and its individual components after multivariable adjustment for baseline clinical characteristics and established biomarkers (adjusted hazard ratio [HR], 2.35). There was also a correlation for increased FGF-23 concentration with an increased risk of all-cause mortality (adjusted HR, 2.27) and CV death, , or stroke (adjusted HR, 1.42). The correlation between FGF-23 and CV risk, including CV or , was attenuated in women versus men (P < 0.001 for interaction).

"In patients stabilized after ACS, elevated FGF-23 concentrations may be associated with recurrent major CV events and all-cause mortality," the authors write.

Several authors disclosed financial ties to the pharmaceutical industry, including GlaxoSmithKline, which funded the study.

Explore further: Lower hospital mortality for acute MI during heart meeting

More information: Abstract/Full Text

Related Stories

Lower hospital mortality for acute MI during heart meeting

March 15, 2018
(HealthDay)—Thirty-day mortality is lower for hospitalization with acute myocardial infarction during Transcatheter Cardiovascular Therapeutics meeting dates, according to a study published online March 9 in the Journal ...

Incomplete revascularization in PCI linked to higher mortality

January 5, 2018
(HealthDay)—The risk of mortality is increased for certain patients undergoing percutaneous coronary intervention (PCI) with incomplete revascularization (IR), according to a study published online Dec. 27 in JAMA Cardiology.

Stem cell factor tied to reduced risk of cardiac events, death

September 1, 2017
(HealthDay)—High levels of stem cell factor (SCF) are associated with reduced risk of mortality and cardiovascular events, according to a study published online Aug. 26 in the Journal of Internal Medicine.

Silent myocardial infarction linked to heart failure risk

January 3, 2018
(HealthDay)—Silent myocardial infarction (SMI) is associated with an increased long-term risk of heart failure, according to a study published in the Jan. 2 issue of the Journal of the American College of Cardiology.

No higher cancer risk seen for heart failure patients

April 12, 2018
(HealthDay)—Heart failure is not associated with an increased risk of cancer, according to a study published in the April 10 issue of the Journal of the American College of Cardiology.

Circulating FGF23 linked to incident coronary heart disease

March 9, 2018
(HealthDay)—Higher circulating fibroblast growth factor 23 (FGF23) concentrations are associated with an increased risk of incident coronary heart disease (CHD), according to a study published online March 7 in JAMA Cardiology.

Recommended for you

Gout could increase heart disease risk

August 17, 2018
Having a type of inflammatory arthritis called gout may worsen heart-related outcomes for people being treated for coronary artery disease, according to new research.

Stroke patients treated at a teaching hospital are less likely to be readmitted

August 17, 2018
Stroke patients appear to receive better care at teaching hospitals with less of a chance of landing back in a hospital during the early stages of recovery, according to new research from The University of Texas Health Science ...

Cardiovascular disease related to type 2 diabetes can be reduced significantly

August 16, 2018
Properly composed treatment and refraining from cigarette consumption can significantly reduce the risk of cardiovascular disease resulting from type 2 diabetes, according to a study published in the New England Journal of ...

Genomic autopsy can help solve unexplained cardiac death

August 15, 2018
Molecular autopsies can reveal genetic risk factors in young people who unexpectedly die, but proper interpretation of the results can be challenging, according to a recent study published in Circulation.

Neonatal pig hearts can heal from heart attack

August 15, 2018
While pigs still cannot fly, researchers have discovered that the hearts of newborn piglets do have one remarkable ability. They can almost completely heal themselves after experimental heart attacks.

Fifty percent of cardiovascular patients suffer from multiple diseases

August 15, 2018
New research led by The University of Western Australia has revealed that one in two patients admitted to hospital with a cardiovascular disease is suffering from multiple chronic medical conditions which required complex ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.