High FGF-23 linked to recurrent cardiac events after ACS

April 23, 2018

(HealthDay)—Elevated fibroblast growth factor 23 (FGF-23) is associated with increased risk of recurrent major cardiovascular (CV) events in patients after an acute coronary syndrome (ACS), according to a study published online April 18 in JAMA Cardiology.

Brian A. Bergmark, M.D., from Brigham and Women's Hospital in Boston, and colleagues measured C-terminal FGF-23 in plasma samples for 4,947 patients within 30 days of ACS and with one additional CV risk factor in the Stabilization of Plaques Using Darapladib-Thrombolysis in Myocardial Infarction 52 trial.

The researchers found that FGF-23 concentration in the top quartile was independently linked to an increased risk of CV death or heart failure hospitalization and its individual components after multivariable adjustment for baseline clinical characteristics and established biomarkers (adjusted hazard ratio [HR], 2.35). There was also a correlation for increased FGF-23 concentration with an increased risk of all-cause mortality (adjusted HR, 2.27) and CV death, , or stroke (adjusted HR, 1.42). The correlation between FGF-23 and CV risk, including CV or , was attenuated in women versus men (P < 0.001 for interaction).

"In patients stabilized after ACS, elevated FGF-23 concentrations may be associated with recurrent major CV events and all-cause mortality," the authors write.

Several authors disclosed financial ties to the pharmaceutical industry, including GlaxoSmithKline, which funded the study.

Explore further: Lower hospital mortality for acute MI during heart meeting

More information: Abstract/Full Text

Related Stories

Lower hospital mortality for acute MI during heart meeting

March 15, 2018
(HealthDay)—Thirty-day mortality is lower for hospitalization with acute myocardial infarction during Transcatheter Cardiovascular Therapeutics meeting dates, according to a study published online March 9 in the Journal ...

Incomplete revascularization in PCI linked to higher mortality

January 5, 2018
(HealthDay)—The risk of mortality is increased for certain patients undergoing percutaneous coronary intervention (PCI) with incomplete revascularization (IR), according to a study published online Dec. 27 in JAMA Cardiology.

Stem cell factor tied to reduced risk of cardiac events, death

September 1, 2017
(HealthDay)—High levels of stem cell factor (SCF) are associated with reduced risk of mortality and cardiovascular events, according to a study published online Aug. 26 in the Journal of Internal Medicine.

Silent myocardial infarction linked to heart failure risk

January 3, 2018
(HealthDay)—Silent myocardial infarction (SMI) is associated with an increased long-term risk of heart failure, according to a study published in the Jan. 2 issue of the Journal of the American College of Cardiology.

No higher cancer risk seen for heart failure patients

April 12, 2018
(HealthDay)—Heart failure is not associated with an increased risk of cancer, according to a study published in the April 10 issue of the Journal of the American College of Cardiology.

Circulating FGF23 linked to incident coronary heart disease

March 9, 2018
(HealthDay)—Higher circulating fibroblast growth factor 23 (FGF23) concentrations are associated with an increased risk of incident coronary heart disease (CHD), according to a study published online March 7 in JAMA Cardiology.

Recommended for you

Novel genetic study sheds new light on risk of heart attack

October 12, 2018
Loss of a protein that regulates mitochondrial function can greatly increase the risk of myocardial infarction (heart attack), Vanderbilt scientists reported Oct. 3 in the journal eLife.

Researchers say ritual for orthodox Jewish men may offer heart benefits

October 11, 2018
A pilot study led by researchers at the University of Cincinnati (UC) College of Medicine suggests Jewish men who practice wearing tefillin, which involves the tight wrapping of an arm with leather banding as part of daily ...

Markers of dairy fat consumption linked to lower risk of type two diabetes

October 10, 2018
Higher levels of biomarkers of dairy fat consumption are associated with a lower risk of developing type 2 diabetes, according to new research published today in PLOS Medicine. The study, in more than 60,000 adults, was undertaken ...

Seed oils are best for LDL cholesterol

October 9, 2018
If you want to lower your low-density lipoprotein cholesterol, called LDL or, colloquially, "bad cholesterol," the research is clear about one thing: You should exchange saturated fats with unsaturated fat. If you want to ...

Micropeptide restores heart function in mice

October 9, 2018
Researchers have discovered a micropeptide molecule that can restore normal heart function in mice, according to a study in eLife.

New risk test for sepsis for heart patients

October 5, 2018
Nearly one in four deaths in people with heart failure are caused by sepsis, according to new research.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.