Most premature infants receive early antibiotics

May 30, 2018

(HealthDay)—Most premature infants receive empirical antibiotic therapy, according to a study published online May 25 in JAMA Network Open.

Dustin D. Flannery, D.O., from the Children's Hospital of Philadelphia, and colleagues examined early antibiotic use among premature infants in a retrospective cohort study using a comprehensive administrative database of inpatient encounters from 297 academic and community U.S. hospitals.

The researchers identified 40,364 very low-birth-weight (VLBW) infants who survived at least one day, including 12,947 extremely low-birth-weight (ELBW) infants. Most had early antibiotic initiation (78.6 and 87 percent of VLBW and ELBW infants, respectively); in temporal trend analyses, there were no differences over time for VLBW or ELBW infants. Over time, a small but significant decrease was seen in the rate of prolonged antibiotic duration for VLBW infants but not for ELBW infants. Across centers, there was variation in early antibiotic exposures; 61.1 and 84.8 percent of centers started antibiotic therapy for more than 75 percent of VLBW and ELBW infants, respectively. There was also variation across centers in the proportion of VLBW and ELBW infants administered prolonged , from 0 to 80.4 percent and from 0 to 92 percent, respectively.

"The variability in exposure rates across centers, however, suggests that neonatal antimicrobial stewardship efforts are warranted to optimize antibiotic use for VLBW and ELBW ," the authors write.

Explore further: Staph sepsis increases mortality in preterm infants

More information: Abstract/Full Text
Editorial

Related Stories

Staph sepsis increases mortality in preterm infants

March 12, 2012
(HealthDay) -- Only about 1 percent of very low birth weight (VLBW) infants develop methicillin-resistant Staphylococcus aureus (MRSA) infections, and the morbidity and mortality are similar to that seen in infants with methicillin-susceptible ...

Severe anemia linked to risk for intestinal disease in premature infants

March 1, 2016
A study from Emory University School of Medicine published in the Journal of the American Medical Association (JAMA) has found that severe anemia, but not red blood cell transfusions (RBC), is associated with an increased ...

Supplemental, nutrient-enriched donor milk does not improve neurodevelopment in VLBW infants

November 8, 2016
Among very low-birth-weight (VLBW) infants, the use of supplemental donor milk compared with formula did not improve neurodevelopment at 18 months, according to a study appearing in the November 8 issue of JAMA.

Does supplemental donor milk instead of formula reduce infections in preterm infants?

May 2, 2016
The combined incidence of serious infection, the intestinal disease necrotizing enterocolitis and death was similar in very low-birth-weight infants who received either pasteurized donor milk or preterm formula supplementation ...

Major surgery associated with increased risk of death or impairment in very-low-birth-weight infants

June 16, 2014
Very-low-birth-weight (VLBW) babies who undergo major surgery appear to have an increased risk of death or subsequent neurodevelopmental impairment (NDI).

Health, wealth and social differences for adults born premature, low-birth-weight

May 23, 2016
Fewer adults who were born prematurely at low-birth weights were employed or had children and they were more likely to have lower incomes, be single and report more chronic health conditions than their normal-birth-weight-term ...

Recommended for you

First biomarker evidence of DDT-autism link

August 16, 2018
A study of more than 1 million pregnancies in Finland reports that elevated levels of a metabolite of the banned insecticide DDT in the blood of pregnant women are linked to increased risk for autism in the offspring. An ...

The inequalities of prenatal stress

August 14, 2018
Exposure to an acute stress in utero can have long-term consequences extending into childhood – but only among children in poor households, according to a new Stanford study that looked at the long-term impact of acute, ...

Promoting HPV vaccine doesn't prompt risky sex by teens: study

August 13, 2018
(HealthDay)—Controversial state laws that promote vaccinating kids against the human papillomavirus (HPV) do not increase the likelihood that teens will engage in risky sexual behavior, a new study contends.

Grip strength of children gives clues about their future health

August 13, 2018
While other studies have shown that muscle weakness as measured by grip strength is a predictor of unhealthy outcomes—including cardiovascular and metabolic diseases, disability and even early mortality—this is the first ...

Prenatal vitamin D pills won't boost babies' growth: study

August 9, 2018
(HealthDay)—For pregnant women who are vitamin D-deficient, vitamin supplements won't improve the growth of their fetus or infant, Canadian researchers report.

Giving kids plates with segments and pictures caused them to eat more vegetables

August 8, 2018
A pair of researchers at the University of Colorado has found that preschool kids ate more vegetables when presented with segmented plates with pictures of fruits and vegetables on them. In their paper published in JAMA Pediatrics, ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.