Screening blood donations for Zika virus is costly, low yield

May 11, 2018

(HealthDay)—Screening blood donations for Zika virus (ZIKV) in the United States is costly with low yield, according to a study published in the May 10 issue of the New England Journal of Medicine.

Paula Saá, Ph.D. from the American Red Cross in Gaithersburg, Md., and colleagues implemented investigational screening of donated blood for ZIKV RNA with transcription-mediated amplification (TMA). Repeat TMA, TMA testing in exploratory minipools, real-time reverse-transcriptase , immunoglobulin M (IgM) serologic testing, and red-cell TMA were performed as confirmatory testing of reactive donations.

The researchers found that 9 percent of the 4,325,889 donations that were screened were initially tested in minipools, and there were no reactive donations. Overall, 160 of the 3,932,176 donations that were subsequently tested individually were initially reactive and nine were confirmed positive. Six of the confirmed positive donations were reactive on repeat TMA; four of these were IgM negative and all three that could be tested were reactive on minipool TMA. Two of the confirmed positive donors had infections that were transmitted locally, six had travelled to ZIKV-active areas, and one had received an experimental ZIKV vaccine. The cost of identifying eight mosquito-borne ZIKV infections through individual-unit nucleic acid testing was $5.3 million per ZIKV RNA-positive donation.

"Screening of U.S. for ZIKV by individual-donation TMA was costly and had a low yield," the authors write.

The study was partially funded by Grifols Diagnostic Solutions.

Explore further: Screening cuts transfusion-transmitted babesiosis risk

More information: Abstract/Full Text
Editorial

Related Stories

Screening cuts transfusion-transmitted babesiosis risk

December 9, 2016
(HealthDay)—Screening for Babesia microti antibodies and DNA in blood-donation samples is associated with a reduction in the risk of transfusion-transmitted babesiosis, according to a study published in the Dec. 8 issue ...

Research addresses the threat of Zika virus to the US blood supply

March 27, 2017
Investigators have shown that certain screening methods that detect the genetic material of Zika virus can be used to ensure that donated blood supplies remain free of the virus.

First test to detect Zika in blood donations approved

October 9, 2017
(HealthDay)—The cobas Zika test has been approved by the U.S. Food and Drug Administration—the first approved screening test to detect the Zika virus in blood donations.

Blood donor screening for hepatitis E reveals incidence is higher than previously reported

April 21, 2017
Results from a study presented today found that the incidence of HEV RNA in asymptomatic blood donors from Germany is higher than previously reported. The study, presented at The International Liver Congress 2017 in Amsterdam, ...

Antibody 'cocktail' can prevent Zika infection but is not effective for treatment of fetuses

April 26, 2018
A "cocktail" of monoclonal antibodies that can prevent Zika virus (ZIKV) infection in primates was not effective for treatment of fetuses, according to a new collaborative study led by a University of Miami Miller School ...

Recommended for you

Study reveals new therapeutic target for slowing the spread of flu virus

June 22, 2018
Influenza A (flu A) hijacks host proteins for viral RNA splicing and blocking these interactions caused replication of the virus to slow, according to new research published in Nature Communications by Kristin W. Lynch, Ph.D., ...

First ancient syphilis genomes decoded

June 21, 2018
An international research team, including scientists from the Max Planck Institute for the Science of Human History, the University of Tübingen, the National School of Anthropology and History in Mexico City, and the University ...

Rhesus macaque model offers route to study Zika brain pathology

June 21, 2018
Rhesus macaque monkeys infected in utero with Zika virus develop similar brain pathology to human infants, according to a report by researchers at the California National Primate Research Center and School of Veterinary Medicine ...

California Aedes mosquitoes capable of spreading Zika

June 21, 2018
Over the last five years, Zika virus has emerged as a significant global human health threat following outbreaks in South and Central America. Now, researchers reporting in PLOS Neglected Tropical Diseases have shown that ...

Breakthrough treatment for crippling jaw disease created

June 20, 2018
A first-ever tissue implant to safely treat a common jaw defect, known as temporomandibular joint dysfunction, has been successfully tested by UCI-led researchers in a large animal model, according to new findings.

Cell-free DNA profiling informative way to monitor urinary tract infections

June 20, 2018
Using shotgun DNA sequencing, Cornell University researchers have demonstrated a new method for monitoring urinary tract infections (UTIs) that surpasses traditional methods in providing valuable information about the dynamics ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.