More variants in DCM-tied genes in alcoholic cardiomyopathy

May 18, 2018

(HealthDay)—Patients with alcoholic cardiomyopathy (ACM) have more variants in dilated cardiomyopathy (DCM)-associated genes than those without ACM, according to a study published in the May 22 issue of the Journal of the American College of Cardiology.

James S. Ware, M.B.B.S., Ph.D., from Imperial College London, and colleagues examined the role of variation in cardiomyopathy-associated in the pathophysiology of ACM. A total of 141 ACM cases, 716 DCM cases, and 445 healthy volunteers were characterized. The prevalence of rare, protein-altering variants in nine genes associated with inherited DCM was assessed.

The researchers found that patients with ACM had a higher prevalence of variants in well-characterized DCM-causing genes than controls (13.5 versus 2.9 percent); the prevalence was similar for patients with ACM and DCM (19.4 percent). Patients with ACM also had a predominant burden of titin truncating variants (TTNtv) (9.9 percent). In a cohort of DCM patients not meeting ACM criteria, there was an interaction between TTN genotype and excess alcohol consumption. On multivariate analysis, an 8.7 percent absolute reduction in ejection fraction was seen in DCM patients with TTNtv who consumed excess alcohol versus those without TTNtv and excess consumption.

"Familial evaluation and genetic testing should be considered in presenting with ACM," the authors write.

Explore further: Genetics should inform care in noncompaction cardiomyopathy

More information: Abstract/Full Text
Editorial (subscription or payment may be required)

Related Stories

Genetics should inform care in noncompaction cardiomyopathy

February 14, 2018
(HealthDay)—Genetic stratification should play a role in clinical care of patients with noncompaction cardiomyopathy (NCCM), according to a study published in the Feb. 20 issue of the Journal of the American College of ...

Adding defibrillator to CRT no benefit in dilated cardiomyopathy

April 3, 2017
(HealthDay)—For patients with heart failure with indications for cardiac resynchronization therapy (CRT), those with ischemic cardiomyopathy (ICM), but not those with nonischemic dilated cardiomyopathy (DCM), benefit from ...

Molecular autopsy IDs causes of sudden arrhythmic death

April 26, 2017
(HealthDay)—Molecular autopsy for electrical disorder and cardiomyopathy genes identifies a modest but realistic yield in sudden arrhythmic death syndrome (SADS), according to a study published online April 24 in the Journal ...

High-intensity exercise harmful in arrhythmogenic cardiomyopathy

April 6, 2018
(HealthDay)—High-intensity exercise in an independent marker for ventricular arrhythmia (VA) in arrhythmogenic cardiomyopathy (AC), according to a study published online March 28 in JACC: Clinical Electrophysiology.

Genotype doesn't predict A-fib in hypertrophic cardiomyopathy

March 21, 2016
(HealthDay)—For patients with hypertrophic cardiomyopathy (HC), genotype does not predict onset or severity of atrial fibrillation (AF), according to a study published in the April 1 issue of The American Journal of Cardiology.

LRRK2 variants linked to lower age at onset of Parkinson's

November 14, 2017
(HealthDay)—The presence of multiple LRRK2 risk variants is associated with a younger age at onset (AAO) of Parkinson's disease (PD), according to a research letter published online Nov. 13 in JAMA Neurology.

Recommended for you

As body mass index increases, blood pressure may as well

August 17, 2018
Body mass index is positively associated with blood pressure, according to the ongoing study of 1.7 million Chinese men and women being conducted by researchers at the Yale Center for Outcomes Research and Evaluation (CORE) ...

Gout could increase heart disease risk

August 17, 2018
Having a type of inflammatory arthritis called gout may worsen heart-related outcomes for people being treated for coronary artery disease, according to new research.

Stroke patients treated at a teaching hospital are less likely to be readmitted

August 17, 2018
Stroke patients appear to receive better care at teaching hospitals with less of a chance of landing back in a hospital during the early stages of recovery, according to new research from The University of Texas Health Science ...

Cardiovascular disease related to type 2 diabetes can be reduced significantly

August 16, 2018
Properly composed treatment and refraining from cigarette consumption can significantly reduce the risk of cardiovascular disease resulting from type 2 diabetes, according to a study published in the New England Journal of ...

Genomic autopsy can help solve unexplained cardiac death

August 15, 2018
Molecular autopsies can reveal genetic risk factors in young people who unexpectedly die, but proper interpretation of the results can be challenging, according to a recent study published in Circulation.

Neonatal pig hearts can heal from heart attack

August 15, 2018
While pigs still cannot fly, researchers have discovered that the hearts of newborn piglets do have one remarkable ability. They can almost completely heal themselves after experimental heart attacks.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.