Recent clinical trial finds tamsulosin not effective in kidney stone passage

June 18, 2018, George Washington University
Credit: CC0 Public Domain

The latest research into finding medications to aid the passage of ureteral or kidney stones has shown that tamsulosin is not effective for patients across the board. Previously approved to help men experiencing enlarged prostates, tamsulosin is an Alpha-1 blocker that, in small studies, had been found to be a promising aid to passing kidney stones.

A recent multi-center clinical trial funded by the National Institute for Diabetes and Digestive and Kidney Diseases, revealed no significant support for the use of for kidney stones. The results, published in JAMA Internal Medicine, found no significant effect of patient-reported passage or capture of the stone.

"There is no known medication for helping pass kidney stones," explained Andrew Meltzer, MD, associate professor of emergency medicine at the George Washington University (GW) School of Medicine and Health Sciences. Current guidelines by the American Urological Society call for all patients with stones to receive tamsulosin to help facilitate passage. "We will likely have to change the guidelines regarding which groups of patients should receive the medication," he said.

During the six-year trial, patients presented to the emergency department describing pain associated with stones. One tablet of tamsulosin was administered per day for 28 days with few patients reporting stone passage.

According to Meltzer, the medication isn't completely out of question. Various subgroup analyses suggest that tamsulosin may work in certain subgroups of patients—those with larger stones or with distal stones.

About 10 percent of people suffer from , which cause excruciating pain that many compare to child birth. It is estimated that the annual medical costs associated with stones are approximately $5 billion.

"We are still looking for noninvasive ways to manage patients who have ureteral stones in order to promote passage and decrease complications and pain," Meltzer said.

The article, "Effect of Tamsulosin on Passage of Symptomatic Ureteral Stones: A Randomized Clinical Trial," is published in JAMA Internal Medicine.

Explore further: Bust up big kidney stones with tamsulosin

More information: Effect of Tamsulosin on Passage of Symptomatic Ureteral Stones: A Randomized Clinical Trial, JAMA Internal Medicine (2018). doi:10.1001/jamainternmed.2018.2259 , jamanetwork.com/journals/jamai … /fullarticle/2684477

Related Stories

Bust up big kidney stones with tamsulosin

July 21, 2015
Tamsulosin works no better than placebo on small kidney stones, but does improve passage of more large kidney stones than placebo does. The results of this large clinical trial evaluating tamsulosin versus placebo were published ...

Alpha blockers more effective for large kidney stones

December 2, 2016
Nearly one in 11 Americans will have a kidney stone in their lifetime, causing pain, sometimes missed work and, often, a lot of money.

New guidelines published for physicians treating patients with kidney stones

August 11, 2016
A new guideline for the surgical management of patients with kidney and/or ureteral stones has been released by the American Urologic Association. Chair of the panel, Dean Assimos, M.D., worked with a team of kidney stone ...

Kidney stones on the rise, study finds

February 13, 2018
Kidney stones are a painful health condition, often requiring multiple procedures at great discomfort to the patient. Growing evidence suggests that the incidence of kidney stones is increasing steadily, especially in women. ...

Kidney stone? Try a roller coaster ride

September 27, 2016
(HealthDay)—Anyone who's suffered a kidney stone just wants the urinary obstruction gone. Now, preliminary research suggests relief might even be fun: a roller coaster ride.

Intestinal calcium absorption may ID individuals at risk of developing kidney stones

June 9, 2016
Measuring intestinal calcium absorption may help to identify individuals who are prone to develop kidney stones, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society of Nephrology ...

Recommended for you

Experimental vaccine shows promise in preventing TB

September 25, 2018
(HealthDay)—Tuberculosis remains the most lethal of infectious diseases worldwide, killing more than 1.6 million people a year. But researchers say a new vaccine might prevent half of full-blown illnesses in infected people ...

New way of determining treatment for staph infections cuts antibiotic use

September 25, 2018
Using a clinical checklist to identify eligible patients, doctors were able to shorten the antibiotic duration for patients with uncomplicated staphylococcal bloodstream infections by nearly two days, Duke Health researchers ...

Researchers seek vaccine for 'traveler's diarrhea'

September 25, 2018
Every year, millions of people have vacations and business trips ruined when they succumb to "traveler's diarrhea" during their journeys. A major cause of traveler's diarrhea is bacteria called Enterotoxigenic E. coli, or ...

Many doctors in India miss TB signs: study

September 25, 2018
Many private sector doctors in India miss the signs of tuberculosis and therefore provide patients inadequate treatment, according to a new study published Tuesday involving people hired to act out the symptoms.

Breakthrough in designing a better Salmonella vaccine

September 24, 2018
UC Davis researchers announce in the Proceedings of the National Academy of Sciences this week a breakthrough in understanding which cells afford optimal protection against Salmonella infection—a critical step in developing ...

Antifungal agent found to be possible treatment for porphyria

September 24, 2018
A large team of researchers from Spain, France and the U.S. has found that a common antifungal agent might be useful as a treatment for a rare type of porphyria. In their paper published in the journal Science Translational ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.