Daily text message may improve adherence and treatment outcomes in patients with gout

June 14, 2018, European League Against Rheumatism

The results of a study presented today at the Annual European Congress of Rheumatology (EULAR 2018) demonstrate significant improvements in adherence and clinical outcomes in gout patients who received a daily text message to remind them to take allopurinol.

Gout is a very common condition. It is caused by deposits of crystals of a substance called uric acid (also known as urate) in the joints, which leads to inflammation. Periods of time when you have gout symptoms are called flares. Flares can be unpredictable and debilitating, developing over a few hours and causing severe pain in the joints. Long-term urate lowering treatments (ULT), such as allopurinol, are recommended in chronic cases of gout to reduce serum urate levels sufficiently to dissolve existing urate crystals and to prevent further crystal formation. However, a recent meta-analysis reported that overall adherence to ULTs was just 47%, which is surprisingly low considering that they do not have significant side effects or require taking tablets several times a day.

"These results are important as the provision of effective interventions to improve low adherence in patients with gout is vital to improve disease-related outcomes," said Professor Thomas Dörner, Chairperson of the Abstract Selection Committee, EULAR.

There were 82 patients with gout in the study, 42 were randomised to receive daily short message reminders to take allopurinol (). The other 40 were randomised to receive a weekly containing information on non-pharmacologic treatment for gout (control group). After 12 weeks, 88.1% of the group were considered adherent versus none of the control group. The relative risk of adherence was calculated at 71.5 with a confidence interval of 4.54-1126.8 (p=0.002). Serum urate level was significantly decreased in both groups, however, the reduction in the intervention group was significantly greater than in the control group (-1.47 ± 0.86 vs. -0.28 ± 0.39 mg/dL, p<0.001). Serum creatinine was also significantly decreased in the intervention group (-0.03 ± 0.09 mg/dL, p<0.031), while serum creatinine was unchanged in the control group.

"Our results clearly show that mobile phone text reminders could be an important tool to enhance allopurinol and help in controlling serum urate levels in gout patients," said Dr. Pongthorn Narongroeknawin, Head of Rheumatic Disease Unit, Phramongkutklao Hospital, Thailand (study author).

Patients included in the study were diagnosed with gout by 1977 ARA classification criteria for , receiving at least one month of allopurinol, and had estimated glomerular filtration rate greater than 30mL/min/1.73m2. There were no significant differences in the baseline characteristics of the intervention vs. control groups; SUA levels of 7.66 ± 1.24 vs. 7.78 ± 1.17 mg/dL, MTB-Thai score of 18.38 ± 0.73 vs. 18.37 ± 0.95.

Explore further: Drug combination benefits patients with tophaceous gout

More information: DOI: 10.1136/annrheumdis-2018-eular.2251

Related Stories

Drug combination benefits patients with tophaceous gout

June 9, 2017
The drug lesinurad in combination with febuxostat was better at lowering blood levels of urate than febuxostat alone in a phase III clinical trial of 324 patients with tophaceous gout. Over 12 months, significantly more patients ...

Febuxostat prevents gout flares in recent clinical trial

October 4, 2017
As reported in the journal Arthritis & Rheumatology, the drug febuxostat reduced gout flares in a double-blind, placebo-controlled study of 314 adults with early gout. Febuxostat treatment also reduced synovitis—or inflammation ...

Gout not associated with increased risk of fracture, study finds

May 14, 2018
Gout, a painful inflammatory arthritis, is not associated with an increased risk of fracture, according to a large study led by Keele University, and published in CMAJ (Canadian Medical Association Journal).

Vitamin C does not lower uric acid levels in gout patients

May 16, 2013
Despite previous studies touting its benefit in moderating gout risk, new research reveals that vitamin C, also known ascorbic acid, does not reduce uric acid (urate) levels to a clinically significant degree in patients ...

Urate-lowering therapy helps chronic kidney disease patients improve organ function

November 13, 2016
Chronic kidney disease patients who take urate-lowering therapy and achieve target urate levels show improvement in kidney function, according to new research findings presented this week at the 2016 ACR/ARHP Annual Meeting ...

Allopurinol does not increase chronic kidney disease risk in gout patients

November 13, 2016
Allopurinol, a widely used treatment for lowering serum urate levels, does not appear to increase risk of kidney deterioration in gout patients with normal or near-normal kidney function, according to new research findings ...

Recommended for you

Dietary carbohydrates could lead to osteoarthritis, new study finds

August 9, 2018
Do your knees ache? According to new findings from the Oklahoma Medical Research Foundation, your diet could be a culprit.

Joint study raises questions about treatments for arthritis

August 3, 2018
A study examining how molecules are transported into knee-joint tissue could have major implications for understanding and treating arthritis.

Researchers identify new arthritis severity gene

July 26, 2018
A new gene associated with disease severity in models of rheumatoid arthritis has been identified by researchers at the Icahn School of Medicine at Mount Sinai. The discovery could provide a new pathway for treatment and ...

How the brain plays a role in rheumatoid arthritis inflammation

June 18, 2018
In patients with chronic inflammatory conditions, such as rheumatoid arthritis, there has been limited understanding of how this inflammation affects the brain.

New 3-D imaging analysis technique could lead to improved arthritis treatment

June 18, 2018
An algorithm to monitor the joints of patients with arthritis, which could change the way that the severity of the condition is assessed, has been developed by a team of engineers, physicians and radiologists led by the University ...

Joint resolution: A link between Huntington's disease and rheumatoid arthritis

May 15, 2018
Using new analytic tools, researchers at University of California San Diego School of Medicine and the Icahn School of Medicine at Mount Sinai have decoded the epigenetic landscape for rheumatoid arthritis (RA), a common ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.