Direct-acting antivirals effective for hepatitis C in seniors

June 26, 2018

(HealthDay)—For older patients with hepatitis C virus (HCV), direct-acting antiviral (DAA) therapy is effective, according to a study published online May 25 in the Journal of the American Geriatrics Society.

Chiara Mazzarelli, M.D., from King's College Hospital in London, and colleagues conducted a retrospective review involving individuals aged 65 years and older treated with DAA for HCV. Participants were divided into two cohorts: 88 aged 65 to 74 years and 25 aged 75 years and older.

The researchers found that the sustained virologic response rate was 97.7 and 95.8 percent in individuals aged 65 to 74 years and those aged 75 years and older, respectively. The likelihood of taking more than two medications per day for chronic conditions (84 versus 62 percent) and that of having clinically significant drug-drug interactions (DDIs) necessitating cessation or adjustment of medications before commencement of DAA therapy (80 versus 36 percent) were increased for individuals aged 75 years and older. The likelihood of experiencing an adverse event (AE) during therapy (50 versus 26 percent) and developing anemia secondary to ribavirin (60 versus 20 percent) was also increased for individuals aged 75 years and older.

"DAA therapy is highly efficacious for the treatment of HCV in , but those aged 75 and older are more likely to have clinically significant pretreatment DDIs and experience AEs, including ribavirin-induced anemia, during therapy," the authors write.

Several authors disclosed financial ties to the pharmaceutical industry.

Explore further: Few receive all high-priority clinical preventive services

More information: Abstract/Full Text (subscription or payment may be required)

Related Stories

Few receive all high-priority clinical preventive services

June 22, 2018
(HealthDay)—Only 8 percent of U.S. adults aged 35 years and older receive all high-priority clinical preventive services, according to a report published in the June issue of Health Affairs.

Older age tied to poorer course of major depressive disorder

June 8, 2018
(HealthDay)—Older age is associated with poorer course of major depressive disorder (MDD), according to a study published online June 7 in The Lancet Psychiatry.

Sleep apnea reporting low among individuals aged 65+

May 24, 2017
(HealthDay)—From 1993 to 2011, physicians reported sleep apnea (SA) in 0.3 percent of all office visits among individuals aged 65 years and older, according to a study published online May 4 in the Journal of the American ...

Intellectual activities in later life may cut dementia risk

June 7, 2018
(HealthDay)—Active participation in intellectual activities among adults aged 65 years or older is associated with reduced risk of dementia, according to a study published online May 30 in JAMA Psychiatry.

ER visit rate 92 per 1,000 for diabetes patients 45 and older

February 8, 2018
(HealthDay)—In 2015, the rate of diabetes-related visits to the emergency department was 92 per 1,000 persons for those aged 45 and older, according to a February data brief published by the U.S. Centers for Disease Control ...

Less than half of seniors with A-fib receive anticoagulants

August 28, 2017
(HealthDay)—Less than 45 percent of older adults with atrial fibrillation (AF) admitted to the hospital are prescribed an anticoagulant, according to a study published online Aug. 21 in the Journal of the American Geriatrics ...

Recommended for you

Deadly Rift Valley fever: New insight, and hope for the future

July 19, 2018
Health control measures alone could be ineffective in the long term fight against the deadly Rift Valley fever which affects both humans and animals, a new study in the journal PNAS reports.

Yeast species used in food industry causes disease in humans

July 19, 2018
A major cause of drug-resistant clinical yeast infections is the same species previously regarded as non-pathogenic and commonly used in the biotechnology and food industries. The study, published on July 19th in the open-access ...

New guidelines to diagnose, manage rare endocrine disorders

July 19, 2018
International guidelines have been published for the first time to help doctors around the globe diagnose and manage patients with a very rare set of endocrine diseases known as pseudohypoparathyroidism and its related disorders, ...

Overuse of antibiotics not what the doctor ordered

July 19, 2018
With increased use of antibiotics worldwide linked to growing antibiotic resistance, a world-first study co-authored by a QUT researcher has highlighted the growing impact of non-prescription supply of antibiotics in community ...

Alcohol-related cirrhosis deaths skyrocket in young adults

July 18, 2018
Deaths from cirrhosis rose in all but one state between 1999-2016, with increases seen most often among young adults, a new study shows.

Childhood abuse linked to greater risk of endometriosis, study finds

July 17, 2018
Endometriosis, a painful condition that affects one in 10 reproductive-age women in the U.S., has been linked to childhood physical and sexual abuse, according to findings published today in the journal Human Reproduction.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.