New guidelines increase melanoma staging reproducibility

June 28, 2018

(HealthDay)—Greater reproducibility and higher concordance are seen for melanoma staging with the American Joint Committee on Cancer (AJCC) classification of cancer staging, the AJCC Cancer Staging Manual, 8th edition (AJCC 8), which includes revisions to definitions of T1a versus T1b or greater, according to a study published online May 18 in JAMA Network Open.

Joann G. Elmore, M.D., M.P.H., from the University of California, Los Angeles, and colleagues compared AJCC 8 with the AJCC Cancer Staging Manual, 7th edition (AJCC 7) in a diagnostic study. A total of 187 pathologists interpreting melanocytic skin lesions completed 4,342 independent case interpretations of 116 invasive .

The researchers found that for T1a diagnoses, participating pathologists' concordance with the consensus reference diagnosis increased from 44 percent with AJCC 7 criteria to 54 percent with AJCC 8 criteria. For cases of T1b or greater, the concordance increased from 72 to 78 percent. There was also an improvement in intraobserver reproducibility of diagnoses, increasing from 59 to 64 percent and from 74 to 77 percent for T1a and T1b or greater invasive melanoma cases, respectively.

"Improved classification of invasive melanoma can be expected after implementation of AJCC 8, suggesting a positive impact on patients. However, despite improvement, concordance and remain low," the authors write.

Two authors disclosed ties to the biotechnology industry.

Explore further: Melanoma staging undergoes evidence-based revision

More information: Abstract/Full Text
Editorial

Related Stories

Melanoma staging undergoes evidence-based revision

October 20, 2017
(HealthDay)—The American Joint Committee on Cancer (AJCC) melanoma staging system has been revised, according to a report published online Oct. 13 in CA: A Cancer Journal for Clinicians.

New guidelines may slightly increase reliability, accuracy of melanoma diagnoses

May 21, 2018
In a new study, researchers have developed updated guidelines for classifying a serious form of skin cancer called invasive melanoma. The American Joint Committee on Cancer, an organization that provides information on "cancer ...

Gene expression profile improves ID of high-risk melanoma

April 27, 2017
(HealthDay)—A validated 31-gene expression profile (GEP) signature improves identification of patients with melanoma at high risk of metastasis when used in combination with the American Joint Committee on Cancer (AJCC) ...

The gold standard in cancer staging now as Web tool

October 5, 2010
Springer is launching the AJCC e-Staging Tool, a web-based application which will improve the way cancer is staged. Designed to meet the needs of the entire multidisciplinary team in any facility that deals with cancer, ...

Study raises concern over accuracy of melanoma diagnoses

June 28, 2017
Concerns over the accuracy of melanoma diagnoses are raised in a study of US pathologists published by The BMJ today.

Reducing Tx may harm safety in early HPV+ oropharyngeal cancer

December 27, 2017
(HealthDay)—For patients with human papillomavirus (HPV)+ stage I or II oropharyngeal cancer, deintensification of treatment from chemoradiotherapy to one modality may compromise safety, according to a study published online ...

Recommended for you

Pancreatic cancer's addiction could be its end

November 13, 2018
Cancer cells are often described as cells "gone bad" or "renegade." New research reveals that in some of the deadliest cases of pancreatic cancer, these rebellious cells have an unexpected addiction. Now, scientists are investigating ...

Cognitive decline—radiation—brain tumor prevented by temporarily shutting down immune response

November 13, 2018
Treating brain tumors comes at a steep cost, especially for children. More than half of patients who endure radiation therapy for these tumors experience irreversible cognitive decline, a side-effect that has particularly ...

Study finds promising therapeutic target for aggressive type of breast cancer

November 13, 2018
A new Nature Communications study led by University of Kentucky Markey Cancer Center researchers suggests that an enzyme known as Prolyl 4-hydroxylase subunit alpha-1 (P4HA1) is a potential therapeutic target for triple negative ...

Solving the mystery of NPM1 in acute myeloid leukemia

November 13, 2018
Although it has long been recognized that mutations of gene NPM1 play an important role in acute myeloid leukemia, no one has determined how the normal and the mutated forms of the protein NPM1 function.

Scientists shine new light on link between obesity and cancer

November 12, 2018
Scientists have made a major discovery that shines a new, explanatory light on the link between obesity and cancer. Their research confirms why the body's immune surveillance systems—led by cancer-fighting Natural Killer ...

Obesity both feeds tumors and helps immunotherapy kill cancer

November 12, 2018
A groundbreaking new study by UC Davis researchers has uncovered why obesity both fuels cancer growth and allows blockbuster new immunotherapies to work better against those same tumors.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.