Leucocyte amount proportions associate with menopausal stage

June 12, 2018, University of Jyväskylä
Credit: University of Jyväskylä

The ERMA cohort comprises women aged 47 to 55 years living in the city of Jyväskylä and surrounding municipalities in Finland. The original invitation was posted to 82% of the cohort and 47% answered the invitation. The prequestionnaire form was received from 3,064 women, who then participated in the first phase of the study. Altogether, 1,158 women participated in the third study phase, which included a wide set-up of physiological and psychological measurements. Women were assigned to pre-, early and late peri-, and postmenopausal groups based on FSH concentrations and a bleeding diary.

ERMA includes a cross-sectional design as well as the follow-up from peri- to postmenopausal stage. The follow-up started in 2014 and lasts to the end of 2018.

Blood count was associated with female sex hormones

"The with leucocyte subtypes was used as one indicator of general health condition of the women," says docent Vuokko Kovanen.

The mean blood count values did not show any clinically critical values in any of the menopausal groups. This means that all blood cell values were at a normal level and, for example, any indications of acute infection, chronic inflammation nor anemia were present.

"Despite this, we found, perhaps a little surprisingly, that the total amount of leucocytes as well as the proportions of leucocyte subtypes showed significantly different values between the groups," explains Kovanen.

Postmenopausal women had a lower amount of total leucocytes and proportion of neutrophilic leucocytes, while the proportion of lymphocytes was higher in comparison to women undergoing perimenopausal transition. Furthermore, the values were associated with estradiol and FSH concentrations.

Lymphocytes and neutrophilic leucocytes are involved in the immune responses and are mediators in inflammatory conditions. These also include, specifically, chronic low-grade inflammation, which intensifies with advancing age and is associated with several chronic diseases.

"Consequently, the follow-up study is very important and is expected to show whether this association is also seen as a change when transition from peri- to postmenopause occurs. Furthermore, we plan to expand the follow-up measurements from postmenopause onwards," explainsAdjunct professor Eija Laakkonen.

ERMA researchers are confident in gathering a range of new knowledge concerning the development of health status among middle-aged and of the effects of menopausal hormonal changes on their health status.

Explore further: Menopausal status may better predict blood vessel health in women than fitness level

More information: Vuokko Kovanen et al. Design and protocol of Estrogenic Regulation of Muscle Apoptosis (ERMA) study with 47 to 55-year-old womenʼs cohort, Menopause (2018). DOI: 10.1097/GME.0000000000001117

Related Stories

Menopausal status may better predict blood vessel health in women than fitness level

August 14, 2017
High physical fitness is known to be related to enhanced blood vessel dilation and blood flow (endothelial function) in aging men. However, for women, endothelial function and the effect of exercise may be related more to ...

Reproductive markers associated with risk of diabetes

May 3, 2018
(HealthDay)—Markers of reproductive history, including age of menarche and parity, may be tied to future diabetes risk in women with a body mass index (BMI) ≥25 kg/m², according to a study published in Diabetes, Obesity ...

Menopause and estrogen affect muscle function

October 3, 2017
According to a study conducted at the University of Jyväskylä, estrogen acts as a regulator of muscle energy metabolism and muscle cell viability. Menopause leads to the cessation of ovarian estrogen production concurrent ...

Never too late: Reaping the benefits of exercise in early postmenopause

February 25, 2017
Women recently postmenopause have similar or improved benefits from physical activity, in terms of muscle and blood vessel function, as those premenopause. Therefore, early postmenopause might be a time when women can gain ...

Treating menopause symptoms reduces abdominal fat tissue

March 27, 2018
Women who undergo hormone therapy to relieve menopausal symptoms tend to have less fat tissue, particularly in the abdomen, than other menopausal women, according to a new study published in the Endocrine Society's Journal ...

Recommended for you

Self-lubricating latex could boost condom use: study

October 17, 2018
A perpetually unctuous, self-lubricating latex developed by a team of scientists in Boston could boost the use of condoms, they reported Wednesday in the journal Royal Society Open Science.

How healthy will we be in 2040?

October 17, 2018
A new scientific study of forecasts and alternative scenarios for life expectancy and major causes of death in 2040 shows all countries are likely to experience at least a slight increase in lifespans. In contrast, one scenario ...

Study finds evidence of intergenerational transmission of trauma among ex-POWs from the Civil War

October 16, 2018
A trio of researchers affiliated with the National Bureau of Economic Research has found evidence that suggests men who were traumatized while POWs during the U.S. Civil War transmitted that trauma to their offspring—many ...

Father's nicotine use can cause cognitive problems in children and grandchildren

October 16, 2018
A father's exposure to nicotine may cause cognitive deficits in his children and even grandchildren, according to a study in mice publishing on October 16 in the open-access journal PLOS Biology by Pradeep Bhide of Florida ...

Many supplements contain unapproved, dangerous ingredients: study

October 13, 2018
(HealthDay)—U.S. health officials have issued more than 700 warnings during the last decade about the sale of dietary supplements that contain unapproved and potentially dangerous drug ingredients, new research reveals.

Age at which women experience their first period is linked to their sons' age at puberty

October 12, 2018
The age at which young women experience their first menstrual bleeding is linked to the age at which their sons start puberty, according to the largest study to investigate this association in both sons and daughters.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.