Mechanism controlling multiple sclerosis risk identified

multiple sclerosis
Demyelination by MS. The CD68 colored tissue shows several macrophages in the area of the lesion. Original scale 1:100. Credit: Marvin 101/Wikipedia

While the DNA sequence remains the same throughout a person's life, the expression of the encoded genes may change with time and contribute to disease development in genetically predisposed individuals. Researchers at Karolinska Institutet in Sweden have now discovered a new mechanism of a major risk gene for multiple sclerosis (MS) that triggers disease through so-called epigenetic regulation. They also found a protective genetic variant that reduces the risk for MS through the same mechanism. The study is published in Nature Communications.

Multiple sclerosis is a of the central nervous system, affecting people at a relatively young age. Most are between 20 and 40 years old when first symptoms present, generally in the form of numbness in the arms and legs, visual impairment, dizziness, fatigue and depression. The symptoms are caused by an inflammation in the brain and the spinal cord that breaks down the myelin sheath protecting the nerves, thus damaging the axons. Currently, there is no cure for MS, but the disease progression can often be halted through medication.

Over 40 years ago, researchers discovered that genetic variation in the so-called HLA region is the strongest risk factor for developing the disease. HLA encodes molecules that are involved in the immune system. However, the specific and molecular mechanisms behind the emergence of the disease are not fully established.

By using molecular analyses and combining several studies (so-called meta-analysis), including around 14,000 patients with MS and a control group of more than 170,000 healthy individuals, researchers at Karolinska Institutet found that people with the major risk HLA-DRB1*15:01 have an increased expression of the HLA-DRB1 gene, thus increasing the risk for the disease. The researchers further discovered a so-called epigenetic regulation of HLA expression as the mechanism mediating this effect.

"We show for the first time that epigenetic mechanisms can cause the . In addition, we can connect this mechanism to the genetic variant with the strongest risk for developing MS," says Maja Jagodic, researcher at the Department of Clinical Neuroscience at Karolinska Institutet and one of the authors of the article.

The researchers also discovered a new HLA gene variant, rs9267649, which reduces the risk of developing MS. This protective variant decreases the HLA-DRB1 gene expression—through the same epigenetic regulation —thus reducing the risk for MS. The results open new avenues for potential alternative treatments based on specific epigenetic modulation, i.e. to prevent gene expression artificially. This gives hope for people with MS, as well as other .

"Almost all autoimmune diseases are associated with HLA," says Lara Kular, co-author and researcher at the same department.


Explore further

Possible mechanism for specific symptoms in bipolar disorder discovered

More information: Lara Kular et al, DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis, Nature Communications (2018). DOI: 10.1038/s41467-018-04732-5
Journal information: Nature Communications

Citation: Mechanism controlling multiple sclerosis risk identified (2018, June 20) retrieved 14 November 2019 from https://medicalxpress.com/news/2018-06-mechanism-multiple-sclerosis.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
8 shares

Feedback to editors

User comments