Medical research

Molecular switch for 'exhaustion mode' of immune cells discovered

Tumors and certain viral infections pose a challenge to the human body which the immune system typically fails to handle. In these diseases it switches to a hypofunctional state that prevents adequate protection. However, ...

Medical research

Rheumatoid arthritic pain could be caused by antibodies

Antibodies that exist in the joints before the onset of rheumatoid arthritis can cause pain even in the absence of arthritis, researchers from Karolinska Institutet in Sweden report. The researchers believe that the finding, ...

Arthritis & Rheumatism

'Locking' an arthritis drug may be key to improving it

Attaching a removable lock to an arthritis drug can make it safer and more effective, according to a new study publishing June 13 in the open-access journal PLOS Biology led by Wen-Wei Lin of Kaohsiung Medical University, ...

Arthritis & Rheumatism

Rheumatoid arthritis—can its onset be delayed or prevented?

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disorder that leads to significant health issues as well as high treatment costs. In this themed issue of Clinical Therapeutics, experts review multiple aspects ...

Oncology & Cancer

Scientists remind immune cells whose side they should be on

International group of scientists in the joint study of the laboratory of the Wistar Institute, University of Pittsburgh, and I.M. Sechenov First Moscow State Medical University discovered the change in activity of one of ...

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Autoimmune disease

Autoimmune diseases arise from an overactive immune response of the body against substances and tissues normally present in the body. In other words, the body really attacks its own cells. This may be restricted to certain organs (e.g. in thyroiditis) or involve a particular tissue in different places (e.g. Goodpasture's disease which may affect the basement membrane in both the lung and the kidney). The treatment of autoimmune diseases is typically with immunosuppression—medication which decreases the immune response.

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